Results 151 to 160 of about 1,367,754 (318)
Pharmacology of Current Drugs in Adjuvant Chemotherapy of Colorectal Cancer
, 2014 Colorectal cancer continues to be one of the most frequently diagnosed malignancies worldwide. While a curative treatment remains surgical excision, chemotherapy is an important treatment in later stages, perhaps due its elimination of micrometastases ...
Chaviv, Sivan
core
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Breast Tumor Susceptibility to Chemotherapy via Support Vector Machines
, 2003 Support vector machines (SVMs), utilizing RNA signature measurements, were used to generate a classi er to distinguish breast cancer patients that are partial-responders to chemotherapy treatment, from patients that are nonresponders.
Mangasarian, Olvi, Fung, Glenn
core
Real-World Evidence of Treatment Patterns, Time to Real-World Progression, and Overall Survival of Patients With Testicular Germ Cell Tumors Receiving Palliative Chemotherapy in the United States. [PDF]
Cancer MedFeldman DR +6 more
europepmc +1 more source