Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
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Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
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Factors influencing anxiety levels in colon cancer patients undergoing chemotherapy after arm venous port implantation: An exploratory study of risk factors. [PDF]
Medicine (Baltimore)Zhang J, Wang X, Han J.
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Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
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Hepatic Arterial Infusion of Chemotherapy for Advanced Hepatocellular Carcinoma
, 2011 Treatment of advanced hepatocellular carcinoma (HCC) remains a significant problem for clinicians. Sorafenib, the only approved agent, improves survival rate, but is associated with a low tumor response rate.
SHAO, YU-YUN;HUANG, CHUN-CHIEH;LIANG, PO-CHIN;LIN, ZONG-ZHE +1 more
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Clinical Outcome in Elderly Patients (Aged ≥ 65 Years) Treated with Chemotherapy for Advanced Soft Tissue Sarcomas: A Tokai Musculoskeletal Oncology Consortium Study. [PDF]
Cancers (Basel)Nakamura T +13 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Subtotal hippocampal resection can leave residual hippocampal tissue, yet the immediate postoperative electrophysiologic evolution of such remnants is unknown. We describe a patient with drug‐resistant temporal lobe epilepsy in whom a hippocampal remnant was continuously monitored using a responsive neurostimulator (RNS) following subtotal ...
Patrick Hartnett +5 more
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The development trajectory of self-advocacy in patients with adjuvant chemotherapy after breast cancer surgery and its predictors. [PDF]
Medicine (Baltimore)Lei S, Zhao S, Chen X.
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