Results 171 to 180 of about 2,075,344 (349)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Sex differences in cachexia outcomes and branched-chain amino acid metabolism following chemotherapy in aged mice. [PDF]

PLoS One
Mora S, Mann G, Adegoke OAJ.
europepmc   +1 more source

Chemotherapy intensification for first-line treatment of poor-prognosis metastatic germ cell cancer is not yet ready for prime time

, 2020
Di Jiang, Robert J. Hamilton, Aaron R. Hansen   +2 more
openalex   +2 more sources

286P Efficacy, safety and pharmacokinetics (PK) of enzalutamide (ENZ) vs placebo (PL) in chemotherapy-naïve patients (pts) with progressive metastatic castration-resistant prostate cancer (mCRPC): An Asian multinational study [PDF]

, 2016
D. Ye, Hyunsu Ahn, Yeong‐Shiau Pu, Weixin Han, L-P. Xie, S-P. Huang, Hui-Ching Wu, Li Ma, Junying Qi, Fang Zhou, Guangxi Sun, L. Chen, Xue Bai, Shunsuke Yamada, Moeko Saito, Kenji Suga, Yongbing Sun   +16 more
openalex   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Continuous hemodiafiltration during chemotherapy for acute kidney injury in spontaneous tumor lysis syndrome due to high-grade B-cell lymphoma: a case report. [PDF]

CEN Case Rep
Kawamura N, Wada Y, Motohashi T, Okawa H, Kawamura S, Sakurabayashi S, Sano K, Takeuchi K, Naito S, Aoyama T, Takeuchi Y.   +10 more
europepmc   +1 more source

Goserelin, as an ovarian protector during (neo)adjuvant breast cancer chemotherapy, prevents long term altered bone turnover

, 2016
Caroline Wilson, Fatma Gossiel, Robert Leonard, Richard A. Anderson, Douglas Adamson, Geraldine Thomas, Robert E. Coleman   +6 more
openalex   +1 more source

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

New England Journal of Medicine, 2017
R. Stone, S. Mandrekar, B. Sanford, K. Laumann, S. Geyer, C. Bloomfield, C. Thiede, T. Prior, K. Döhner, G. Marcucci, F. Lo‐Coco, R. Klisovic, A. Wei, J. Sierra, M. Sanz, J. Brandwein, T. D. de Witte, D. Niederwieser, F. Appelbaum, B. Medeiros, M. Tallman, J. Krauter, R. Schlenk, A. Ganser, H. Serve, G. Ehninger, S. Amadori, R. Larson, H. Döhner   +28 more
semanticscholar   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Perioperative penpulimab-based combination therapy in patients with resectable non-small cell lung cancer (ALTER-L043): an open-label, multicenter, randomized, phase II trial. [PDF]

Signal Transduct Target Ther
Wang M, Liu W, Guo H, Long H, Yu B, Zhao G, Wu J, Yue D, Zhao X, Li C, Zhang L, Wang S, Zhang Q, Zhang Z, Wang C.   +14 more
europepmc   +1 more source