Results 31 to 40 of about 2,840,126 (395)
Candidate genes in gastric cancer identified by constructing a weighted gene co-expression network [PDF]
PeerJ, 2018 Background Gastric cancer (GC) is one of the most common cancers with high mortality globally. However, the molecular mechanisms of GC are unclear, and the prognosis of GC is poor.
Jian Chen +5 more
doaj +2 more sources
Increased survival with enzalutamide in prostate cancer after chemotherapy.
New England Journal of Medicine, 2012 BACKGROUND Enzalutamide (formerly called MDV3100) targets multiple steps in the androgen-receptor-signaling pathway, the major driver of prostate-cancer growth.
H. Scher +19 more
semanticscholar +1 more source
A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients. [PDF]
, 2015 BACKGROUND: Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell ...
Aittomäki, Kristiina +44 more
core +3 more sources
Chemotherapy versus supportive care in advanced non-small cell lung cancer: improved survival without detriment to quality of life [PDF]
, 2004 BACKGROUND: In 1995 a meta-analysis of randomised trials investigating the value of adding chemotherapy to primary treatment for non-small cell lung cancer (NSCLC) suggested a small survival benefit for cisplatin-based chemotherapy in each of the primary
Brown, J. +14 more
core +2 more sources
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.
New England Journal of Medicine, 2013 BACKGROUND In single-group studies, chromosomal rearrangements of the anaplastic lymphoma kinase gene (ALK) have been associated with marked clinical responses to crizotinib, an oral tyrosine kinase inhibitor targeting ALK. Whether crizotinib is superior
A. Shaw +22 more
semanticscholar +1 more source
21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer.
New England Journal of Medicine, 2021 BACKGROUND The recurrence score based on the 21-gene breast-cancer assay has been clinically useful in predicting a chemotherapy benefit in hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative, axillary lymph-node-negative ...
K. Kalinsky +33 more
semanticscholar +1 more source
CNS Oncology, 2015 The treatment of glial brain tumors begins with surgery, and standard adjuvant treatment at the end of the past millennium for high-grade glioma and high-risk low-grade glioma was radiotherapy and chemotherapy was given at recurrence. However, over the past 10 years much has changed regarding the role of chemotherapy in gliomas and it is now clear that
Jacoline E C Bromberg +2 more
openaire +4 more sources
The known-unknown: third- and fourth-generation cephalosporins combined with sulbactam [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2023 Despite the presence of more than 100 different antibacterials in the therapeutic arsenal, beta-lactam antibiotics, in general, and the third-generation cephalosporins, in particular, remain the main option for the treatment of the most of infections in ...
Stetsiouk O.U. +3 more
doaj +1 more source
New England Journal of Medicine, 2002 BACKGROUND The survival of patients with diffuse large-B-cell lymphoma after chemotherapy is influenced by molecular features of the tumors. We used the gene-expression profiles of these lymphomas to develop a molecular predictor of survival.
A. Rosenwald +39 more
semanticscholar +1 more source
Mechanisms of Multidrug Resistance in Cancer Chemotherapy
International Journal of Molecular Sciences, 2020 Cancer is one of the main causes of death worldwide. Despite the significant development of methods of cancer healing during the past decades, chemotherapy still remains the main method for cancer treatment. Depending on the mechanism of action, commonly
K. Bukowski, M. Kciuk, R. Kontek
semanticscholar +1 more source