Results 51 to 60 of about 1,486,273 (317)

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Cisplatin-Based Chemotherapy for Pulmonary Metastasized Germ Cell Tumors of the Testis - Be Aware of Acute Respiratory Distress Syndrome [PDF]

, 2009
Background: Cisplatin-based combination chemotherapy is regarded as standard of care for patients with advanced germ cell tumors. In patients with lung metastases and a high tumor load, an association between induction chemotherapy and the development of
Parhofer, Klaus G., Baumann, Anja, Hausmann, Andreas, Boeck, Stefan, Metzeler, Klaus H., Gallmeier, Eike, Stemmler, Hans-Joachim   +6 more
core   +1 more source

Antimicrobial resistance of nosocomial Staphylococcus aureus isolates in Russia: results of multicenter epidemiological study «MARATHON» 2013-2014 [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2017
The study included 418 of the 841 clinical isolates of S. aureus, which were regarded as nosocomial. These 418 clinical nosocomial S. aureus strains were isolated in 2013-2014 from patients hospitalized in 25 hospitals in 19 Russian cities.
Romanov A.V., Dekhnich A.V., Sukhorukova M.V., Skleenova E.Yu., Ivanchik N.V., Edelstein M.V., Kozlov R.S., «MARATHON» Study Group   +7 more
doaj  

Role of endogenous and exogenous antioxidants in risk of six cancers: evidence from the Mendelian randomization study

Frontiers in Pharmacology, 2023
Background: Although oxidative stress is known to contribute to cancer, and endogenous and exogenous antioxidants are thought to prevent tumorigenesis by suppressing oxidative stress-induced DNA damage, antioxidants have also been reported to show ...
Jiahao Zhu, Jie Lian, Xin Wang, Ren Wang, Xiangyi Pang, Benjie Xu, Xing Wang, Chenyang Li, Shengjun Ji, Haibo Lu   +9 more
doaj   +1 more source

Ewing Sarcoma in Infants and Children Under 2 Years of Age: A French Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ewing sarcoma, the second most common primary bone cancer in children, requires intensive treatment that may lead to significant long‐term sequelae, particularly in infants. We retrospectively analyzed data from 1621 French patients treated between 1988 and 2015 within the EW88/93/97 or EE99 trials, focusing on 17 infants diagnosed before 24 ...
Elodie Verdier, Nathalie Cozic, Marie‐Dominique Tabone, Gaelle Pierron, Perrine Marec‐Berard, Sarah Winter, Gabriel Revon‐Rivière, Cyril Lervat, Dominique Plantaz, Marie‐Pierre Castex, Gregory Guimard, Estelle Thebaud, Stephanie Proust, Laure Saumet, Natacha Entz‐Werle, Sophie Taque, Cécile Vérité, Marta Jimenez, Nathalie Gaspar   +18 more
wiley   +1 more source

Efficacy of consolidation high-dose chemotherapy with ifosfamide, carboplatin and etoposide (HD-ICE) followed by autologous peripheral blood stem cell rescue in chemosensitive patients with metastatic soft tissue sarcomas [PDF]

, 2006
Background: Prognosis of patients with metastatic soft tissue sarcomas (MSTS) is poor even after response to doxorubicin-based chemotherapy. We report phase II data of highdose chemotherapy and peripheral blood stem cell (PBSC) rescue in patients with ...
Hentrich, M., Licht, Thomas, Straka, Christian, Rolf-Dieter Issels, Wendtner, Clemens-Martin, Marcus Schlemmer, Hiddemann, Wolfgang, Abdel-Rahman, Sultan, Sultan Abdel-Rahman, Issels, Rolf-Dieter, Salat, C., Baumert, Jens, Straka, C., Hiddemann, W., Falk, Martin, Issels, R.D., Wolfgang Hiddemann, Martin Falk, Jens Baumert, Falk, M., Thomas Licht, Schlemmer, M., Marcus Hentrich, Licht, T., Salat, Christoph, Christoph Salat, Abdel-Rahman, S., Clemens-Martin Wendtner, Schlemmer, Marcus, Wendtner, C.M., Baumert, J.J., Hentrich, Marcus, Christian Straka, Schlemmer, Marcus;Wendtner, Clemens-Martin;Falk, Martin;Abdel-Rahman, Sultan;Licht, Thomas;Baumert, Jens;Straka, Christian;Hentrich, Marcus;Salat, Christoph;Hiddemann, Wolfgang;Issels, Rolf-Dieter   +33 more
core   +1 more source

TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity

Scientific Reports, 2017
ROS1 rearrangement is observed in 1–2% of non-small cell lung cancers (NSCLC). The ROS1 tyrosine kinase inhibitor (TKI) crizotinib has induced marked tumour shrinkage in ROS1-rearranged cancers.
Hayato Ogura, Yuka Nagatake-Kobayashi, Jun Adachi, Takeshi Tomonaga, Naoya Fujita, Ryohei Katayama   +5 more
doaj   +1 more source

Global Efforts to Reduce Paediatric Cancer Care Disparities in Radiotherapy: A Decade Change

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We present an update on the status, needs and challenges faced by paediatric imaging and radiotherapy (RT) programmes globally after a previous survey conducted by the International Atomic Energy Agency (IAEA) 10 years prior. Methods We developed and distributed a 121‐question survey to radiation oncologists, medical physicists and ...
Raymond B. Mailhot Vega, Daniel J. Indelicato, Jeanette Parkes, Natia Esiashvili, Josué Hernández Benítez, Miriam Mikhail‐Lette, Olivera Cirajc Bjelac, Daniel Berger, Eva Ciurana, Yavuz Anacak, Lisbeth Cordero‐Mendez   +10 more
wiley   +1 more source

Impact of febrile neutropenia on R-CHOP chemotherapy delivery and hospitalizations among patients with diffuse large B-cell lymphoma [PDF]

, 2011
PURPOSE: This analysis from an observational study of clinical practice describes the impact of febrile neutropenia (FN) on chemotherapy delivery and hospitalizations.
Rossi, F G, Lugtenburg, P.J. (Pieternella), Pieternella J. Lugtenburg, Ulrich Dührsen, Bendall, K. (Kate), Dührsen, U. (Ulrich), Silvestre, AS, Francesca G. Rossi, Jaeger, U, Jaeger, Ulrich, Gaia Rossi, F. (Francesca), Matthias Schwenkglenks, Pettengell, R, Schwenkglenks, Matthias, Rossi, FG, Salar Silvestre, A, Dührsen, U, Szabo, C. (Csilla), Johnson, Hans E., Dührsen, Ulrich, Schwenkglenks, M, Bendall, Kate, Lugtenburg, PJ, Rossi, Francesca G, Hans E. Johnson, Rossi, Francesca G., Bendall, K, Jaeger, U. (Ulrich), Szabo, Z, Johnsen, HE, Silvestre, Antonio Salar, Johnson, H.E. (Hans), Pettengell, Ruth, Lugtenburg, Pieternella J., Lugtenburg, Pieternella J, Zsolt Szabo, Ruth Pettengell, Johnsen, Hans E, Szabo, Zsolt, Silvestre, J.S. (Jean Sebastien), Schwenkglenks, M. (Matthias), Pettengell, R. (Ruth), Antonio Salar Silvestre, Ulrich Jaeger, Johnson, H E, Lugtenburg, P J, Kate Bendall   +46 more
core   +1 more source

Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation

Scientific Reports, 2022
The unfolded protein response (UPR) is an adaptive stress response pathway that is essential for cancer cell survival under endoplasmic reticulum stress such as during glucose starvation.
Kazuhiro Kunimasa, Chika Ikeda-Ishikawa, Yuri Tani, Satomi Tsukahara, Junko Sakurai, Yuka Okamoto, Masaru Koido, Shingo Dan, Akihiro Tomida   +8 more
doaj   +1 more source