Results 61 to 70 of about 1,902,419 (312)

TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity

Scientific Reports, 2017
ROS1 rearrangement is observed in 1–2% of non-small cell lung cancers (NSCLC). The ROS1 tyrosine kinase inhibitor (TKI) crizotinib has induced marked tumour shrinkage in ROS1-rearranged cancers.
Hayato Ogura, Yuka Nagatake-Kobayashi, Jun Adachi, Takeshi Tomonaga, Naoya Fujita, Ryohei Katayama   +5 more
doaj   +1 more source

Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation

Scientific Reports, 2022
The unfolded protein response (UPR) is an adaptive stress response pathway that is essential for cancer cell survival under endoplasmic reticulum stress such as during glucose starvation.
Kazuhiro Kunimasa, Chika Ikeda-Ishikawa, Yuri Tani, Satomi Tsukahara, Junko Sakurai, Yuka Okamoto, Masaru Koido, Shingo Dan, Akihiro Tomida   +8 more
doaj   +1 more source

Comparative Effect of Maitake Pro4x with Chemotherapy Breast Cancer Treatment [PDF]

, 2017
Conventional treatments for breast cancer involve surgery followed by radiation and hormonal therapy and/or chemotherapy. Some of these treatments have toxic side effects.
Aguilera Braico, Diego Máximo, Balogh, Gabriela Andrea, Brie, Belen, Roldán Deamicis, Agustina   +3 more
core   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

The Increased Incidence of Nausea and Vomiting Due to Anxiety in Paclitaxel Carboplatin Chemotherapy in a 48 Years Old Female Patient with Cervical Cancer: a Case Report [PDF]

, 2014
Nausea and vomiting was the frequently side effects in chemotherapy.Uncontrolled nausea and vomiting can cause weakened body condition, reduced appetite and drinking, dehydration, electrolyte disturbances, reduced nutritional status so the patient ...
Noviyani, R. (R), Putra, I. F. (I), Suwiyoga, and, K   +2 more
core  

The next steps in improving the outcomes of advanced ovarian cancer [PDF]

, 2015
Worldwide ovarian cancer affects over 200,000 women per year. Overall survival rates are poor due to two predominate reasons. First, the majority of patients present with advanced disease creating significant difficulty with effecting disease eradication.
Blagden, S, Fotopoulou, C, Gabra, H, Openshaw, MR   +3 more
core   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Long-term therapeutic response in gallbladder cancer — the potential of chemoimmunotherapy

Oncology in Clinical Practice
Malignant biliary tract tumors, including gallbladder cancer and cholangiocarcinoma, are associated with particularly poor prognoses. For many years, chemotherapy with cisplatin and gemcitabine was the only available treatment option for patients with ...
Marta Pabianek, Magdalena Sobocinska, Barbara Lochowska, Magdalena A. Ciążyńska   +3 more
doaj   +1 more source

Ceftaroline fosamil – fifth-generation cephalosporin with anti-MRSA activity in the treatment of severe infections in pediatric practice [PDF]

Клиническая микробиология и антимикробная химиотерапия
Сeftaroline fosamil is a fifth-generation cephalosporin and a unique β-lactam and the only currently registered in the Russian Federation cephalosporin with activity against MRSA. Сeftaroline is approved for use in pediatric practice for the treatment of
Andreeva I.V., Stetsiouk O.U., Kozlov R.S.   +2 more
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source