Results 161 to 170 of about 9,484 (238)

Organ‐specific terpenoid responses in Tanacetum vulgare are chemotype‐dependent

Plant Biology, Volume 28, Issue 5, Page 1437-1453, August 2026.
Common tansy varieties defend differently: some boost root chemicals against soil pests, while others release stronger leaf scents against aphids. Abstract Specialized metabolites such as terpenoids are known to mediate plant defence mechanisms. However, how terpenoid diversity governs inducible chemistry across organs remains poorly understood.
H. Newrzella, R. Heinen, C. M. Villasante, I. Zimmer, B. Weber, P. Kary, G. Gerl, A. Neuhaus, A. Sigalas, L. Ojeda‐Prieto, J. B. Winkler, W. W. Weisser, J.‐P. Schnitzler   +12 more
wiley   +1 more source

Assessing the Biogeographic Risks of Potentially Toxic Plants-A Case Study for a Novel Locoweed <i>Sphaerophysa salsula</i> in China. [PDF]

Ecol Evol
Zhang YY, Liu HQ, Wang TT, Wang YN, Li YZ.   +4 more
europepmc   +1 more source

Sultams as Dual Inhibitors of Human Carbonic Anhydrase and Thioredoxin Reductase

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
A series of sultam‐based N‐acyl derivatives with potential applications as dual TrxR1 and CA inhibitors were synthesized and evaluated. TrxR1 screening identified several active compounds, with inhibitory potency influenced by the type and orientation of substituents.
Aleksandrs Pustenko, Raitis Bobrovs, Venkatesan Saravanan, Kathir Avan, Simone Carradori, Antons Sizovs, Andrea Angeli, Claudiu T. Supuran, Raivis Žalubovskis   +8 more
wiley   +1 more source

Multifaceted anti-infective efficacy of <i>Alstonia scholaris</i> (Mizoram chemotype) against fungal, malarial, and intestinal helminth pathogens: <i>in vitro</i> validation and molecular docking insights. [PDF]

Vet World
Lalngaihmanawmi L, Lalthanpuii PB, Lalruatfela B, Nundanga L, Lalchhandama K.   +4 more
europepmc   +1 more source

1‐Aryl‐6,7‐Dimethoxy‐3,4‐Dihydroisoquinoline‐2(1H)‐Sulfonamides as hCA XII Selective Inhibitors: Experimental and Theoretical Studies to Interrogate the Isoform Selectivity

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
Experimental and theoretical studies have disclosed the more relevant structural requirements for effective inhibition and an impressing selectivity toward tumor‐expressed hCA XII isoform over hCA II. Human carbonic anhydrase XII (hCA XII) represents an important pharmacological target for different types of cancer.
Federico Ricci, Anna Di Fiore, Andrea Angeli, Laura De Luca, Francesca Mancuso, Davide Esposito, Giuseppina De Simone, Claudiu T. Supuran, Rosaria Gitto   +8 more
wiley   +1 more source

Plastic Responses to Single and Combined Environmental Stresses in a Highly Chemodiverse Aromatic Plant Species. [PDF]

Physiol Plant
Xiao X, Dussarrat T, Ziaja D, Seymen YB, Brokate L, Jakobs R, Weber B, Winkler JB, Schnitzler JP, Müller C.   +9 more
europepmc   +1 more source

Novel Inhibitors of Carbonic Anhydrase I and II Identified by High Throughput Virtual Screening and Validated by X‐Ray Crystallography

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
High‐throughput virtual screening identifies novel carbonic anhydrase II ligands from large chemical libraries, enabling rapid hit discovery. Structural validation by X‐ray crystallography confirms the predicted binding modes and reveals key protein–ligand interactions.
Asher L. Brandt, Joseph Venditto, Marta Ferraroni, Claudiu T. Supuran, Andrea Angeli   +4 more
wiley   +1 more source

Joint genetic control of isoflavones and soyasaponins revealed by mGWAS, genomic prediction, and SHAP-guided allele stacking. [PDF]

Sci Rep
Kwon H, Song SY, Cho Y, Ra JE, Ha J.
europepmc   +1 more source

Hierarchical Chemotaxonomic Differentiation in Cannabis Chemovars Using Quantitative HPLC Cannabinoid Profiling and Multivariate Chemometrics. [PDF]

Plants (Basel)
Mayong A, Sreewongchai T, Limsuwan S, Tansakul N.   +3 more
europepmc   +1 more source

Discovery of Novel Chemotype LRRK2 Inhibitors Through AlphaFold2-Generated Structure-Based Docking Screen. [PDF]

Int J Mol Sci
Baral R, Lee JI, Jee JG.
europepmc   +1 more source