Results 61 to 70 of about 19,491 (256)

Chemotypes of Pistacia atlantica Leaf Essential Oils from Algeria

Natural Product Communications, 2010
The essential oils obtained by hydrodistillation of Pistacia atlantica Desf. leaves collected from different regions of Algeria were analyzed by GC and GC-MS. The essential oil was rich in monoterpenes and oxygenated sesquiterpenes.
Nadhir Gourine, Isabelle Bombarda, Mohamed Yousfi, Emile M. Gaydou   +3 more
doaj   +1 more source

Closing the Yield Gap for Cannabis: A Meta-Analysis of Factors Determining Cannabis Yield

Frontiers in Plant Science, 2019
Until recently, the commercial production of Cannabis sativa was restricted to varieties that yielded high-quality fiber while producing low levels of the psychoactive cannabinoid tetrahydrocannabinol (THC).
Rachel Backer, Timothy Schwinghamer, Phillip Rosenbaum, Vincent McCarty, Samuel Eichhorn Bilodeau, Dongmei Lyu, Md Bulbul Ahmed, George Robinson, Mark Lefsrud, Olivia Wilkins, Donald L. Smith   +10 more
doaj   +1 more source

Plant chemical variation mediates soil bacterial community composition

Scientific Reports, 2023
An important challenge in the study of ecosystem function is resolving how plant antiherbivore chemical defence expression may influence plant-associated microbes, and nutrient release.
Robert W. Buchkowski, Klára Benedek, János Bálint, Attila Molnár, Tamás Felföldi, Csaba Fazakas, Oswald J. Schmitz, Adalbert Balog   +7 more
doaj   +1 more source

A mass spectrometry-guided genome mining approach for natural product peptidogenomics. [PDF]

, 2011
Peptide natural products show broad biological properties and are commonly produced by orthogonal ribosomal and nonribosomal pathways in prokaryotes and eukaryotes.
Cimermancic, Peter, Dorrestein, Pieter C, Fenical, William, Fischbach, Michael A, Kersten, Roland D, Moore, Bradley S, Nam, Sang-Jip, Xu, Yuquan, Yang, Yu-Liang   +8 more
core  

Scaffold Diversity of Fungal Metabolites [PDF]

, 2017
Many drug discovery projects rely on commercial compounds to discover active leads. However, current commercial libraries, with mostly synthetic compounds, access a small fraction of the possible chemical diversity. Natural products, in contrast, possess
Cedric J. Pearce, John R. Owen, José L. Medina-Franco, Mariana González-Medina, Mario Figueroa, Nicholas H. Oberlies, Tamam El-Elimat   +6 more
core   +1 more source

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, EarlyView.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

Discovery of new G-quadruplex binding chemotypes

Chem. Commun., 2014
We report a novel furan-based low molecular weight chemotype with high G-quadruplex affinity and potent anti-proliferative activity.
Ohnmacht, SA, Varavipour, E, Nanjunda, R, Pazitna, I, Di Vita, G, Gunaratnam, M, Kumar, A, Ismail, MA, Boykin, DW, Wilson, WD, Neidle, S   +10 more
openaire   +4 more sources

Unlocking the Multifunctional Properties of Litsea cubeba Essential Oil: Composition, Antimicrobial, Antibiofilm and Insecticidal Activities

Flavour and Fragrance Journal, EarlyView.
Unveiling the chemical and biological properties of Litsea cubeba essential oil. ABSTRACT Litsea cubeba essential oil (LCEO) is recognised for its broad spectrum of biological activities, including antimicrobial and insecticidal effects, making it a promising natural alternative to synthetic agents.
Miroslava Kačániová, Minhang Qiao, Alessandro Bianchi, Joel Horacio Elizondo‐Luevano, Anis Ben Hsouna, Rania Ben Saad, Zhaojun Ban, Li Li, Jian Lou, Wissem Mnif, Stefania Garzoli   +10 more
wiley   +1 more source

CHEMOTYPE VERBOCCIDENTAFURAN IN Baccharis punctulata (Asteraceae): FURANIC SESQUITERPENES CORRELATION AND MOLECULAR DOCKING INTO THE BENZODIAZEPINE RECEPTOR [PDF]

Química Nova
The compound verboccidentafuran (1) was identified from the essential oil of the leaves of Baccharis punctulata DC. (Asteraceae) specimens for the first time in Brazil.
Jociani Ascari, Murilo S. de Oliveira, André L. Rüdiger, Elaine Elisabetsky, Domingos S. Nunes, Jorge Iulek, Dilamara R. Scharf, Gustavo Heiden   +7 more
doaj   +1 more source

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. [PDF]

, 2008
The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly for combinations of ...
Aizenstein, Brian, Apsel, Beth, Blair, Jimmy A, Feldman, Morri E, Gonzalez, Beatriz, Hoffman, Randy, Knight, Zachary A, Nazif, Tamim M, Shokat, Kevan M, Williams, Roger L   +9 more
core