Results 61 to 70 of about 14,379 (215)
Trends and Future Directions in Organic Chemistry for Drug Discovery
Chemistry – A European Journal, EarlyView.Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
wiley +1 more source
Selective N‐Functionalization of Pyrazoles
European Journal of Organic Chemistry, EarlyView.This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek +2 more
wiley +1 more source
CropsThe key objective of this study was to determine the yield and chemical composition of eight commercial samples and one collected sample of common vervain (Verbena officinalis L.) herb essential oil (EO) originating from seven different countries, and ...
Ain Raal +6 more
doaj +1 more source
The scaled map of a chemotype-specific locus found in this study.
, 2019 The scaled map of a chemotype-specific locus found in this study.
Haifei Yan (484350) +7 more
core +1 more source
Exploration, EarlyView.This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi +5 more
wiley +1 more source
Microcystis Chemotype Diversity in the Alimentary Tract of Bigheaded Carp
Toxins, 2019 Most cyanobacterial organisms included in the genus Microcystis can produce a wide repertoire of secondary metabolites. In the mid-2010s, summer cyanobacterial blooms of Microcystis sp. occurred regularly in Lake Balaton.
Milán Riba +9 more
doaj +1 more source
Flavour and Fragrance Journal, EarlyView.Elsholtzia strobilifera (Benth.) EO: in‐depth chemical and biological investigation. ABSTRACT Species of the genus Elsholtzia (Lamiaceae) have been traditionally used in folk medicine and are known for their diverse biological properties. However, the chemical composition and bioactivity of the essential oil from Elsholtzia strobilifera (Benth.) Benth.
Priyanka Bhatt +7 more
wiley +1 more source
, 2019 Malaria is the most common parasitic disease worldwide, and the third deadliest infection after HIV and tuberculosis. Due to the risk of diffusion of artemisinin resistance in Africa, new drugs for ensuring efficacious antimalarial treatment are urgently
Ivan Bassanini +4 more
core +2 more sources
First Phytochemical Evidence of Chemotypes for the Seagrass Zostera noltii
Plants, 2012 The variability of the flavonoid content of two populations of Z. noltii from different geographical zones, i.e., the Bay of Arcachon and the Bay of Cadiz, was evaluated.
Micheline Grignon-Dubois +1 more
doaj +1 more source
, 2018 Valeriana jatamansi Jones is an aromatic medicinal herb and important alternative to V. officinalis, which is utilized for medicinal purposes in China and India and also as spices in India. Bioactive ingredients of V. jatamansi vary in different regions.
Zhonglin Sun (5494964) +8 more
core +1 more source