Results 51 to 60 of about 9,484 (238)

Composition and Antioxidant Activity of Essential Oils of H.B.K. grown in Colombia

Natural Product Communications, 2008
Microwave-assisted hydrodistillation, simultaneous distillation-solvent extraction, and supercritical fluid extraction, were used to isolate secondary metabolites from two Lippia origanoides chemotypes growing wild in Colombia.
Elena Stashenko, Carlos Ruiz, Amner Muñoz, Martha Castañeda, Jairo Martínez   +4 more
doaj   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

A Unified Hierarchical Multiscale Fusion Framework for Drug–Target Affinity Prediction: From Benchmark Performance to Nanomolar Inhibitor Discovery

Advanced Science, EarlyView.
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu, Xiang Zhang, Haixia Feng, Yuquan Li, Xiaoqing Gong, Yong Liang, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Chemotypes of Pistacia atlantica Leaf Essential Oils from Algeria

Natural Product Communications, 2010
The essential oils obtained by hydrodistillation of Pistacia atlantica Desf. leaves collected from different regions of Algeria were analyzed by GC and GC-MS. The essential oil was rich in monoterpenes and oxygenated sesquiterpenes.
Nadhir Gourine, Isabelle Bombarda, Mohamed Yousfi, Emile M. Gaydou   +3 more
doaj   +1 more source

Closing the Yield Gap for Cannabis: A Meta-Analysis of Factors Determining Cannabis Yield

Frontiers in Plant Science, 2019
Until recently, the commercial production of Cannabis sativa was restricted to varieties that yielded high-quality fiber while producing low levels of the psychoactive cannabinoid tetrahydrocannabinol (THC).
Rachel Backer, Timothy Schwinghamer, Phillip Rosenbaum, Vincent McCarty, Samuel Eichhorn Bilodeau, Dongmei Lyu, Md Bulbul Ahmed, George Robinson, Mark Lefsrud, Olivia Wilkins, Donald L. Smith   +10 more
doaj   +1 more source

Chemotypic Characterization and Biological Activity of Rosmarinus officinalis [PDF]

Foods, 2017
Rosemary (Rosmarinus officinalis L.) is a popular herb in cooking, traditional healing, and aromatherapy. The essential oils of R. officinalis were obtained from plants growing in Victoria (Australia), Alabama (USA), Western Cape (South Africa), Kenya, Nepal, and Yemen. Chemical compositions of the rosemary oils were analyzed by gas chromatography-mass
Prabodh Satyal, Tyler Jones, Elizabeth Lopez, Robert McFeeters, Nasser Ali, Iman Mansi, Ali Al-kaf, William Setzer   +7 more
openaire   +3 more sources

CHEMOTYPE VERBOCCIDENTAFURAN IN Baccharis punctulata (Asteraceae): FURANIC SESQUITERPENES CORRELATION AND MOLECULAR DOCKING INTO THE BENZODIAZEPINE RECEPTOR [PDF]

Química Nova
The compound verboccidentafuran (1) was identified from the essential oil of the leaves of Baccharis punctulata DC. (Asteraceae) specimens for the first time in Brazil.
Jociani Ascari, Murilo S. de Oliveira, André L. Rüdiger, Elaine Elisabetsky, Domingos S. Nunes, Jorge Iulek, Dilamara R. Scharf, Gustavo Heiden   +7 more
doaj   +1 more source

Plant chemical variation mediates soil bacterial community composition

Scientific Reports, 2023
An important challenge in the study of ecosystem function is resolving how plant antiherbivore chemical defence expression may influence plant-associated microbes, and nutrient release.
Robert W. Buchkowski, Klára Benedek, János Bálint, Attila Molnár, Tamás Felföldi, Csaba Fazakas, Oswald J. Schmitz, Adalbert Balog   +7 more
doaj   +1 more source

The Essential Oil Composition in Commercial Samples of Verbena officinalis L. Herb from Different Origins

Crops
The key objective of this study was to determine the yield and chemical composition of eight commercial samples and one collected sample of common vervain (Verbena officinalis L.) herb essential oil (EO) originating from seven different countries, and ...
Ain Raal, Getter Dolgošev, Tetiana Ilina, Alla Kovalyova, Martin Lepiku, Andriy Grytsyk, Oleh Koshovyi   +6 more
doaj   +1 more source

Dosing PPARγ Activation With Light Using Fast Relaxing Photoswitches

Angewandte Chemie International Edition, EarlyView.
To achieve spatiotemporal control over PPARγ activity, we designed the fast‐relaxing photoswitchable agonist 6 that selectively activates PPARγ in its light‐induced Z‐state and relaxes within seconds (t1/2 47 s) to the inactive E‐state. This unique profile allowed light‐dosed receptor activation in in vitro settings, enabling biological studies on ...
Loris Knümann, Alba Rodriguez‐Paniagua, Martin Reynders, Silke Duensing‐Kropp, Oliver Thorn‐Seshold, Vasily Morozov, Julian A. Marschner, Daniel Merk   +7 more
wiley   +1 more source