Results 51 to 60 of about 12,690 (274)

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Composition and Antioxidant Activity of Essential Oils of H.B.K. grown in Colombia

Natural Product Communications, 2008
Microwave-assisted hydrodistillation, simultaneous distillation-solvent extraction, and supercritical fluid extraction, were used to isolate secondary metabolites from two Lippia origanoides chemotypes growing wild in Colombia.
Elena Stashenko, Carlos Ruiz, Amner Muñoz, Martha Castañeda, Jairo Martínez   +4 more
doaj   +1 more source

Genotypic and Environmental Effects on the Volatile Chemotype of Valeriana jatamansi Jones [PDF]

, 2018
Valeriana jatamansi Jones is an aromatic medicinal herb and important alternative to V. officinalis, which is utilized for medicinal purposes in China and India and also as spices in India. Bioactive ingredients of V. jatamansi vary in different regions.
Zhentian Lei, Zili Yin, Zhonglin Sun, Huiru Tang, Jiayi Shi, Xingchao He, Zigang Qian, Shiyu Wang, Hui Xie   +8 more
core   +1 more source

Genetic control of the chemotype in Cannabis sativa [PDF]

, 2023
[SPA] El modelo actual de herencia del quimiotipo en Cannabis sativa se centra en las dos sintasas terminales de la ruta biosintética de los cannabinoides, THCAS y CBDAS.
Egea Gutiérrez-Cortines, Marcos, Weiss, Julia Rosl, Gila Navarro, Alberto   +2 more
core   +1 more source

Hydrothermal Humification of Biomass for Circular Carbon Management in Sustainable Agro‐Ecosystems

Advanced Science, EarlyView.
This article provides a comprehensive overview of biomass hydrothermal humification for building sustainable agro‐ecosystems. It examines the chemical transformation mechanisms and the functional benefits of the produced humic acids in soil remediation.
Ziyun Liu, Zonglu Yao, Yuanhui Zhang, Huiyan Zhang, Lixin Zhao   +4 more
wiley   +1 more source

Chemotypes of Pistacia atlantica Leaf Essential Oils from Algeria

Natural Product Communications, 2010
The essential oils obtained by hydrodistillation of Pistacia atlantica Desf. leaves collected from different regions of Algeria were analyzed by GC and GC-MS. The essential oil was rich in monoterpenes and oxygenated sesquiterpenes.
Nadhir Gourine, Isabelle Bombarda, Mohamed Yousfi, Emile M. Gaydou   +3 more
doaj   +1 more source

Chemotype-Enrichment Workflow: A univariate analysis workflow for exploring chemical feature enrichments across EPA’s ToxCast chemical-assay landscape

, 2018
Presentation to the American Chemical Society Spring Meeting Mar ...
Ryan Lougee (5871513)
core   +1 more source

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

Image Annotation and Database Mining to Create a Novel Screen for the Chemotype-Dependent Crystallization of HCV NS3 Protease

, 2016
An effective process for screening, imaging, and optimizing crystallization trials using a combination of external and internal hardware and software has been deployed. The combination of this infrastructure with a vast annotated crystallization database
Herbert E. Klei (486974), Matthew H. Cahn (2213065), Jeffrey Tredup (2213062), Kevin Kish (1399378), Javed Khan (219271), ChiehYing Chang (1442719), Steve J. Michalczyk (2213059), Mark F. Russo (2213056), Eric T. Baldwin (2175346)   +8 more
core   +2 more sources