Results 31 to 40 of about 9,405 (216)
Secondary Site Ligand for Integrin αVβ3 Enables Targeted mRNA Delivery
Angewandte Chemie, EarlyView.Non‐orthosteric, low‐affinity ligands for integrin αVβ3, identified by fragment screening, achieve superselective nanoparticle targeting (ακ ≈ 3) of αVβ3‐overexpressing endothelial cells. Unlike traditional arginine–glycine–aspartate decorated particles, these fragment‐functionalized LNPs discriminate cells by receptor density and deliver mRNA to ...
Sebastian Bayer +7 more
wiley +2 more sources
Factors Influencing Deoxynivalenol Accumulation in Small Grain Cereals
Toxins, 2012 Deoxynivalenol (DON) is a mycotoxin produced by the plant pathogenic fungi Fusarium graminearum and F. culmorum. These and other closely related fungi cause a disease known as Fusarium head blight (FHB) in small grain cereals.
Stephen N. Wegulo
doaj +1 more source
Natural Product Communications, 2020 The volatile oils of fresh and air-dried buds of 3 different varieties of Cannabis, namely, high cannabidiol (CBD) chemotype, intermediate CBD/tetrahydrocannabinol (THC) chemotype, and high THC chemotype were prepared by hydrodistillation.
Amira S. Wanas +8 more
doaj +1 more source
Structural and Functional Siderophore Remodeling by Enzymatic Delipidation
Angewandte Chemie, EarlyView.A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog +5 more
wiley +2 more sources
Comparative analysis of content and composition of essential oils of Thymus vulgaris L. from different regions of Europe [PDF]
Proceedings of the Estonian Academy of SciencesCommon thyme (Thymus vulgaris L., Lamiaceae) is one of the most well-known plants in the world, widely used in medicine, culinary arts, and cosmetics. The aim of this study was to analyse the content and composition of essential oils (EO) obtained from ...
Ain Raal +5 more
doaj +1 more source
Frontiers in Plant Science, 2023 IntroductionAtractylodes lancea is widely distributed in East Asia, ranging from Amur to south-central China. The rhizome of A. lancea is commonly used in traditional Chinese medicine, however, the quality of products varies across different regions with
Chengcai Zhang +12 more
doaj +1 more source
The p53-MDM2/MDMX axis – A chemotype perspective [PDF]
MedChemComm, 2011 The protein-protein interaction (PPI) of the tumor suppressor p53 and its negative regulator MDM2 consists of the most intense studied PPI with a group of small molecular weight antagonists described and many more disclosed in patent literature. Due to the Å-level structural insight into p53 interaction with MDM2 there is a reasonable understanding of ...
Khoury, K. +3 more
openaire +3 more sources
Direct Regioselective para‐Fluorination via I(I)/I(III) Catalysis
Angewandte Chemie, EarlyView.A direct, para‐selective fluorination by I(I)/I(III) catalysis is disclosed that does not require substrate pre‐functionalization. This strategy leverages the Leonard link inherent to phenylpropanoate and phenylpropanamides to promote a spirocyclization/para‐selective sequence. The C3‐side chain maps onto a range of common drug scaffolds and allows the
Christoph Roblick +5 more
wiley +2 more sources
MoleculesThis present study aims to characterize the essential oil compositions of the aerial parts of M. spicata L. and endemic M. longifolia ssp. cyprica (Heinr. Braun) Harley by using GC-FID and GC/MS analyses simultaneously.
Hasan İsfendiyaroğlu +5 more
doaj +1 more source
A survey of Fusarium species and ADON genotype on Canadian wheat grain
Frontiers in Fungal Biology, 2022 IntroductionWheat is a staple food that is important to global food security, but in epidemic years, fungal pathogens can threaten production, quality, and safety of wheat grain.
Janice Bamforth +15 more
doaj +1 more source