Results 11 to 20 of about 14,379 (215)

Discovery of a novel pseudo-natural product Aurora kinase inhibitor chemotype through morphological profiling [PDF]

, 2023
The pseudo-natural product (pseudo-NP) concept aims to combine NP fragments in arrangements that are not accessible through known biosynthetic pathways.
Slava, Ziegler, Carsten, Strohmann, Axel, Pahl, Herbert, Waldmann, Michael, Grigalunas, Lin, Wang, Luca, Greiner, Sonja, Sievers, Beate, Schölermann, Daniel, Foley, Okan, Yildirim, Furkan, Yilmaz, Sukdev, Bag, Rebecca, Scheel   +13 more
core   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)-Linked Neuroinflammation. [PDF]

Adv Sci (Weinh)
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Sillapachaiyaporn C, Wang W, Qin Y, Yan L, Scheeff S, He X, Wu Q, Lin Y, Shang J, Ye X, Liu J, Sun K, Yeung CW, Huang J, Chen Z, Liu X, Geng Y, Au SWN, Ip BY, Ko H, Ng BW.   +20 more
europepmc   +2 more sources

Genetic approaches to chemotype determination in type B-trichothecene producing Fusaria [PDF]

, 2014
This review summarises the genetic methods used for chemotype determination of the main Fusarium type B-trichothecene producing species. Literature on Fusarium chemotype epidemiology over the last 15 years is reviewed in order to describe temporal and ...
Pasquali, Matias, Migheli, Quirico, Q. Migheli, M. Pasquali   +3 more
core   +1 more source

Detailed Phytochemical Analysis of High- and Low Artemisinin-Producing Chemotypes of Artemisia annua

Frontiers in Plant Science, 2018
Chemical derivatives of artemisinin, a sesquiterpene lactone produced by Artemisia annua, are the active ingredient in the most effective treatment for malaria. Comprehensive phytochemical analysis of two contrasting chemotypes of A.
Tomasz Czechowski, Tony R. Larson, Theresa M. Catania, David Harvey, Cenxi Wei, Michel Essome, Geoffrey D. Brown, Ian A. Graham   +7 more
doaj   +1 more source

Clinopodium nepeta Essential Oil and Its Major Constituents Pulegone and Menthone: Composition and Activity Against Verticillium dahliae, Phytophthora infestans, and Macrophomina phaseolina. [PDF]

Chem Biodivers
Chemical fractionation of Clinopodium nepeta essential oil reveals pulegone and menthone as markedly more potent antifungal isolates than the whole oil, with activity varying among pathogens. Pulegone exhibits superior efficacy against Verticillium dahliae and Phytophthora infestans, whereas menthone shows enhanced activity against Macrophomina ...
Taibi M, Elbouzidi A, Haddou M, Beraich A, Baraich A, Bellaouchi R, Addi M, Chaabane K, Jaouadi B, Zarai N, Guerrouj BE, Asehraou A.   +11 more
europepmc   +2 more sources

Growth Year and Chemotype Synergistically Regulate Coumarin Accumulation and the Associated Transcriptional Profiles in <i>Peucedanum praeruptorum</i> Dunn. [PDF]

Plants (Basel)
Peucedanum praeruptorum is increasingly cultivated as wild resources are depleted. However, cultivated plants often contain lower levels of coumarins than wild individuals and may not meet the standards of the Chinese Pharmacopoeia.
Jiang J, Liu Y, Yang J, Feng L, Wen D, Li M, Zhu Z, Wang Q, Gao Z, Wei J.   +9 more
europepmc   +2 more sources

Identifying Novel Anti-Osteoporosis Leads with a Chemotype-Assembly Approach

, 2019
In this paper, we applied a chemotype-assembly approach for ligand-based drug discovery (LBDD) to discover novel anti-osteoporosis leads. With this new approach, we identified 12 chemotypes and derived 18 major chemotype assembly rules from 245 known ...
Dane Huang (514967), Shimin Su (6808514), Jun Xu (45543), Ruyue Li (6416690), Chao Zhao (253684), Yida Xu (6808511), Qiong Gu (562902)   +6 more
core   +2 more sources

Factors Influencing Deoxynivalenol Accumulation in Small Grain Cereals

Toxins, 2012
Deoxynivalenol (DON) is a mycotoxin produced by the plant pathogenic fungi Fusarium graminearum and F. culmorum. These and other closely related fungi cause a disease known as Fusarium head blight (FHB) in small grain cereals.
Stephen N. Wegulo
doaj   +1 more source

Comparative analysis of content and composition of essential oils of Thymus vulgaris L. from different regions of Europe [PDF]

Proceedings of the Estonian Academy of Sciences
Common thyme (Thymus vulgaris L., Lamiaceae) is one of the most well-known plants in the world, widely used in medicine, culinary arts, and cosmetics. The aim of this study was to analyse the content and composition of essential oils (EO) obtained from ...
Ain Raal, Tetiana Gontova, Maie Palmeos, Anne Orav, Galiya Sayakova, Oleh Koshovyi   +5 more
doaj   +1 more source

Chemical Composition of Volatile Oils of Fresh and Air-Dried Buds of Cannabis hemovars, Their Insecticidal and Repellent Activities

Natural Product Communications, 2020
The volatile oils of fresh and air-dried buds of 3 different varieties of Cannabis, namely, high cannabidiol (CBD) chemotype, intermediate CBD/tetrahydrocannabinol (THC) chemotype, and high THC chemotype were prepared by hydrodistillation.
Amira S. Wanas, Mohamed M. Radwan, Suman Chandra, Hemant Lata, Zlatko Mehmedic, Abbas Ali, KHC Baser, Betul Demirci, Mahmoud A. ElSohly   +8 more
doaj   +1 more source