Results 11 to 20 of about 12,690 (274)
Diaryl Ureas as an Antiprotozoal Chemotype
ACS Infectious Diseases, 2021 We now describe the physicochemical profiling, in vitro ADME, and antiparasitic activity of eight N,N′-diarylureas to assess their potential as a broad-spectrum antiprotozoal chemotype. Chromatographic LogD(7.4) values ranged from 2.5 to 4.5; kinetic aq.
Cal, Monica +32 more
core +4 more sources
TRI Genotyping and Chemotyping: A Balance of Power [PDF]
Toxins, 2020 Fusarium is among the top 10 most economically important plant pathogens in the world. Trichothecenes are the principal mycotoxins produced as secondary metabolites by select species of Fusarium and cause acute and chronic toxicity in animals and humans upon exposure either through consumption and/or contact.
Ria T. Villafana +2 more
openaire +3 more sources
Antitumor Cannabinoid Chemotypes: Structural Insights [PDF]
Frontiers in Pharmacology, 2019 Cannabis has long been known to limit or prevent nausea and vomiting, lack of appetite, and pain. For this reason, cannabinoids have been successfully used in the treatment of some of the unwanted side effects caused by cancer chemotherapy. Besides their palliative effects, research from the past two decades has demonstrated their promising potential ...
Morales, Paula, Jagerovic, Nadine
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, 2023 The pseudo-natural product (pseudo-NP) concept aims to combine NP fragments in arrangements that are not accessible through known biosynthetic pathways.
Slava, Ziegler +13 more
core +1 more source
Novel Toxoplasma gondii inhibitor chemotypes [PDF]
Parasitology International, 2018 We profiled three novel T. gondii inhibitors identified from an antimalarial phenotypic high throughput screen (HTS) campaign: styryl 4-oxo-1,3-benzoxazin-4-one KG3, tetrahydrobenzo[b]pyran KG7, and benzoquinone hydrazone KG8. These compounds inhibit T.
A G, Sanford +10 more
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The chemotype core collection of genus Nicotiana
The Plant Journal, 2022 SUMMARYSustainable production of chemicals and improving these biosources by engineering metabolic pathways to create efficient plant‐based biofactories relies on the knowledge of available chemical/biosynthetic diversity present in the plant. Nicotiana species are well known for their amenability towards transformation and other new plant breeding ...
Drapal, Margit +2 more
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Genetic approaches to chemotype determination in type B-trichothecene producing Fusaria [PDF]
, 2014 This review summarises the genetic methods used for chemotype determination of the main Fusarium type B-trichothecene producing species. Literature on Fusarium chemotype epidemiology over the last 15 years is reviewed in order to describe temporal and ...
Pasquali, Matias +3 more
core +1 more source
CHEMOTYPIC Variation in Volatiles and Herbivory for Sagebrush [PDF]
Journal of Chemical Ecology, 2016 Plants that are damaged by herbivores emit complex blends of volatile compounds that often cause neighboring branches to induce resistance. Experimentally clipped sagebrush foliage emits volatiles that neighboring individuals recognize and respond to. These volatiles vary among individuals within a population.
Richard Karban +2 more
openaire +4 more sources
Occurrence of the d-Proline Chemotype in Enzyme Inhibitors [PDF]
Symmetry, 2019 Natural and nonnatural amino acids represent important building blocks for the development of peptidomimetic scaffolds, especially for targeting proteolytic enzymes and for addressing protein–protein interactions. Among all the different amino acids derivatives, proline is particularly relevant in chemical biology and medicinal chemistry due to its ...
Lenci E., Trabocchi A.
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Molecules, 2022 Ocimum campechianum Mill. (Peruvian basil) is an essential oil-bearing plant of the Lamiaceae family. Volatile oil produced through steam distillation of Peruvian basil was examined to establish the aromatic and stable isotope profiles of samples (n = 9)
Tyler M. Wilson +5 more
doaj +1 more source