Results 41 to 50 of about 14,379 (215)

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Foeniculum vulgare miller, a new chemotype from Montenegro [PDF]

, 2021
Previous studies relating to prolonged and fractionated distillation procedures highlighted essential oils’ (EOs) chemical composition to be significantly dependent on the extraction duration and harvesting time.
Ragno R., Sapienza F., Garzoli S., Vujovic S., Bozovic M.   +4 more
core   +1 more source

A Unified Hierarchical Multiscale Fusion Framework for Drug–Target Affinity Prediction: From Benchmark Performance to Nanomolar Inhibitor Discovery

Advanced Science, EarlyView.
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu, Xiang Zhang, Haixia Feng, Yuquan Li, Xiaoqing Gong, Yong Liang, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Seasonal Variation of Essential Oils Composition in a Genetically Diverse Population of Lippia alba and Its Influence on Antibacterial Activity [PDF]

Chem Biodivers
The essential oils profile, antibacterial activity and leaf nutrients contents of a Lippia alba genetically diverse population are examined regarding seasonal harvesting. ABSTRACT Lippia alba is an aromatic plant whose essential oils (EOs) have been characterized as promising antimicrobial agents. It has been established that L.
Santos M, Botelho T, Delarmelina C, Siqueira W, Duarte M, Marques M, Mondego J.   +6 more
europepmc   +2 more sources

A Versatile DNA‐Encoded Library Platform for the Discovery of Highly Cooperative Chemical Inducers of Proximity

Advanced Science, EarlyView.
We present a versatile DNA‐encoded library (DEL) platform designed for rapid library synthesis and subsequent screening for chemical inducers of proximity (CIPs) across various presenter proteins of choice. Applying this approach, we discovered a novel molecular glue‐like compound mediating CRBN‐BRD9 ternary complex formation with remarkable ...
Bingqi Tong, Sunny A. Tang, Yifan Deng, Zhihan Nan, Alison X. Gao, Gregory A. Michaud, Simone Bonazzi, Frédéric Berst, Frédéric J. Zécri, Shuang Liu, William J. Gibson, Stuart L. Schreiber   +11 more
wiley   +1 more source

Composition and Antioxidant Activity of Essential Oils of H.B.K. grown in Colombia

Natural Product Communications, 2008
Microwave-assisted hydrodistillation, simultaneous distillation-solvent extraction, and supercritical fluid extraction, were used to isolate secondary metabolites from two Lippia origanoides chemotypes growing wild in Colombia.
Elena Stashenko, Carlos Ruiz, Amner Muñoz, Martha Castañeda, Jairo Martínez   +4 more
doaj   +1 more source

Full-Length Transcriptome Sequencing and Different Chemotype Expression Profile Analysis of Genes Related to Monoterpenoid Biosynthesis in Cinnamomum porrectum

, 2019
Leaves of C. porrectum are rich in essential oils containing monoterpenes, sesquiterpenes and aromatic compounds, but the molecular mechanism of terpenoid biosynthesis in C. porrectum is still unclear.
Hongming Wang, Xindong Wang, Xiaohua Su, Yongjie Zheng, Xinliang Liu, Fengying Qiu   +5 more
core   +1 more source

Is the Fgap1 mediated response to oxidative stress chemotype-dependent in Fusarium graminearum?

, 2016
International audienceThis study aims to compare the role of the transcription factor Fgap1 in oxidative stress response for two Fusarium graminearum strains belonging to the two chemotypes DON/ADON and NIV/FX.
Zehraoui, Enric, Barreau, Christian,, Bonnin-Verdal, Marie-Noëlle, Barreau, Christian, C., Khosravi, Claire, Richard-Forget, Florence, Forget, Richard-Forget, Florence,, Montibus, Mathilde   +7 more
core   +1 more source

Image Annotation and Database Mining to Create a Novel Screen for the Chemotype-Dependent Crystallization of HCV NS3 Protease

, 2016
An effective process for screening, imaging, and optimizing crystallization trials using a combination of external and internal hardware and software has been deployed. The combination of this infrastructure with a vast annotated crystallization database
Herbert E. Klei (486974), Matthew H. Cahn (2213065), Jeffrey Tredup (2213062), Kevin Kish (1399378), Javed Khan (219271), ChiehYing Chang (1442719), Steve J. Michalczyk (2213059), Mark F. Russo (2213056), Eric T. Baldwin (2175346)   +8 more
core   +2 more sources