Results 41 to 50 of about 9,405 (216)

Discrimination of Fennel Chemotypes Applying IR and Raman Spectroscopy: Discovery of a New γ-Asarone Chemotype

Journal of Agricultural and Food Chemistry, 2014
Various vibrational spectroscopy methods have been applied to classify different fennel chemotypes according to their individual profile of volatile substances. Intact fennel fruits of different chemotypes could be successfully discriminated by attenuated total reflectance Fourier transform infrared (ATR-FTIR) and near infrared (NIR) spectroscopy ...
Krähmer, Andrea, Gudi, Gennadi, Krüger, Hans, Henning, Lothar, Schulz, Hartwig   +4 more
openaire   +3 more sources

Underexplored Catalysts as General Structures: Application of Machine Learning Techniques for Reaction‐Specific Datasets

Angewandte Chemie, EarlyView.
Bias‐aware machine learning identified an underexplored imidazolidinone catalyst with broad competitive performance in iminium‐based reactions. Experimental benchmarking shows how data‐driven prioritization can uncover overlooked catalyst scaffolds from sparse and historically biased literature data.
Jiajing Li, Isaiah O. Betinol, Junshan Lai, Soresu Juyo, Jolene P. Reid   +4 more
wiley   +2 more sources

A COMPARISON OF DIFFERENT LIPOPOLYSACCHARIDE CHEMOTYPES FROM ESCHERICHIA COLI AND SALMONELLA UPON SYNTHESIS OF TNFα AND IL-6 BY MACROPHAGE-LIKE THP-1 CELLS

Медицинская иммунология, 2014
. Present study was performed to investigate the influence of polysaccharide fragment or lipid A upon induction of TNFα and IL-6 cytokines. The study was performed with human THP-1 monocytic leukemia cells that were induced to differentiate into ...
E. V. Voloshina, S. V. Zubova, S. V. Prokhorenko, N. I. Kosjakova, I. R. Prokhorenko   +4 more
doaj   +1 more source

A Comprehensive 19F NMR Framework for Fragment‐Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR

Angewandte Chemie, EarlyView.
NMR screening is a powerful method for hit detection in drug‐discovery. We designed and validated the OpenFL600 19F$^{19}{\rm F}$ NMR library to probe diverse targets, including RNA, GPCRs, kinases, and proteases. This library yields target‐specific ligands without generating promiscuous binders.
Simon H. Rüdisser, Gabriela Stadler, Giacomo Padroni, Daria Barbash, Marco M. Ruckstuhl, Nils Lorz, Christina Jordan, Sarah Skibinski, Timo T. Stühlinger, Sarah E. Kratzwald, Katharina M. Siess, Sven Brüschweiler, Gerald Platzer, Antoine Cléry, Robert Konrat, Frédéric H.‐.T. Allain, Alvar D. Gossert   +16 more
wiley   +2 more sources

Comparative Chemical Profiles and Phytotoxic Activity of Essential Oils of Two Ecospecies of Pulicaria undulata (L.) C.A.Mey

Plants, 2021
The Asteraceae (Compositae) family is one of the largest angiosperm families that has a large number of aromatic species. Pulicaria undulata is a well-known medicinal plant that is used in the treatment of various diseases due to its essential oil (EO ...
Ahmed M. Abd-ELGawad, Saud L. Al-Rowaily, Abdulaziz M. Assaeed, Yasser A. EI-Amier, Abd El-Nasser G. El Gendy, Elsayed Omer, Dakhil H. Al-Dosari, Giuliano Bonanomi, Hazem S. Kassem, Abdelsamed I. Elshamy   +9 more
doaj   +1 more source

Essential Oil Yield and Composition of the Balkan Endemic Satureja pilosa Velen. (Lamiaceae)

Molecules, 2020
Satureja pilosa Velen. senso lato is a Balkan endemic plant that is not well characterized and is found on rocky outcrops of limestone base in Stara Planina (the Balkan Mountains) and the Rhodope Mountains.
Ivanka B. Semerdjieva, Valtcho Zheljazkov, Charles L. Cantrell, Tess Astatkie, Abbas Ali   +4 more
doaj   +1 more source

Exploring the chemotypic variability of Silybum marianum and Silybum eburneum by biochemical and genetic characterization

Frontiers in Plant Science
The Silybum genus belonging to the Asteraceae family, is composed of two species, marianum and eburneum, although, in the past, their classification was not always appropriate.
Marianna Pasquariello, Marianna Pasquariello, Tommaso Martinelli, Roberta Paris, Roberta Paris, Anna Moschella, Roberto Colombo, Alice Di Bello, Jessica Frigerio, Jessica Frigerio, Abdenour Kheloufi, Mohammad Amin Mirzaabolghasemi, Damiano Puglisi, Damiano Puglisi, Salvatore Esposito, Salvatore Esposito, Stefano Scalercio, Stefano Scalercio, Nino Virzì, Pasquale De Vita, Pasquale De Vita, Nicola Pecchioni, Laura Bassolino, Laura Bassolino   +23 more
doaj   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

A new chemotype with promise against Trypanosoma cruzi [PDF]

Bioorganic & Medicinal Chemistry Letters, 2020
Pyridyl benzamide 2 is a potent inhibitor of Trypanosoma cruzi, but not other protozoan parasites, and had a selectivity-index of ≥10. The initial structure-activity relationship (SAR) indicates that benzamide and sulfonamide functional groups, and N-methylpiperazine and sterically unhindered 3-pyridyl substructures are required for high activity ...
Wang, X., Cal, M., Kaiser, M., Buckner, F. S., Lepesheva, G. I., Sanford, A. G., Wallick, A. I., Davis, P. H., Vennerstrom, J. L.   +8 more
openaire   +4 more sources