Results 21 to 30 of about 12,690 (274)

The p53-MDM2/MDMX axis – A chemotype perspective [PDF]

MedChemComm, 2011
The protein-protein interaction (PPI) of the tumor suppressor p53 and its negative regulator MDM2 consists of the most intense studied PPI with a group of small molecular weight antagonists described and many more disclosed in patent literature. Due to the Å-level structural insight into p53 interaction with MDM2 there is a reasonable understanding of ...
Khoury, K., Popowicz, G., Holak, T., Domling, A.   +3 more
openaire   +3 more sources

Detailed Phytochemical Analysis of High- and Low Artemisinin-Producing Chemotypes of Artemisia annua

Frontiers in Plant Science, 2018
Chemical derivatives of artemisinin, a sesquiterpene lactone produced by Artemisia annua, are the active ingredient in the most effective treatment for malaria. Comprehensive phytochemical analysis of two contrasting chemotypes of A.
Tomasz Czechowski, Tony R. Larson, Theresa M. Catania, David Harvey, Cenxi Wei, Michel Essome, Geoffrey D. Brown, Ian A. Graham   +7 more
doaj   +1 more source

Machine learning approaches to study the structure-activity relationships of LpxC inhibitors

EXCLI Journal : Experimental and Clinical Sciences, 2023
Antimicrobial resistance (AMR) has emerged as one of the global threats to human health in the 21st century. Drug discovery of inhibitors against novel targets rather than conventional bacterial targets has been considered an inevitable strategy for the ...
Tianshi Yu, Li Chuin Chong, Chanin Nantasenamat, Nuttapat Anuwongcharoen, Theeraphon Piacham   +4 more
doaj   +1 more source

Foeniculum vulgare miller, a new chemotype from Montenegro [PDF]

, 2021
Previous studies relating to prolonged and fractionated distillation procedures highlighted essential oils’ (EOs) chemical composition to be significantly dependent on the extraction duration and harvesting time.
Ragno R., Sapienza F., Garzoli S., Vujovic S., Bozovic M.   +4 more
core   +2 more sources

Thymol Chemotype Thymus vulgaris L. Hydrolate: Volatile Chemical Fraction Composition and Antimicrobial Activity Against Bacterial and Fungal Pathogens. [PDF]

Chem Biodivers
Phytochemistry and bioactivity of thymol chemotype Thymus vulgaris L. hydrolate. ABSTRACT The increasing prevalence of antimicrobial resistance necessitates the development of alternative antimicrobial agents derived from natural sources. This study evaluated the volatile chemical profile and antimicrobial activity of a thymol‐containing hydrolate ...
Garzoli S, Elizondo-Luevano JH, Ben Hsouna A, Ben Saad R, Kačániová M.   +4 more
europepmc   +2 more sources

Identifying Novel Anti-Osteoporosis Leads with a Chemotype-Assembly Approach

, 2019
In this paper, we applied a chemotype-assembly approach for ligand-based drug discovery (LBDD) to discover novel anti-osteoporosis leads. With this new approach, we identified 12 chemotypes and derived 18 major chemotype assembly rules from 245 known ...
Dane Huang (514967), Shimin Su (6808514), Ruyue Li, Ruyue Li (6416690), Qiong Gu, Chao Zhao (253684), Qiong Gu (562902), Dane Huang, Jun Xu, Jun Xu (45543), Yida Xu, Shimin Su, Yida Xu (6808511), Chao Zhao   +13 more
core   +2 more sources

Factors Influencing Deoxynivalenol Accumulation in Small Grain Cereals

Toxins, 2012
Deoxynivalenol (DON) is a mycotoxin produced by the plant pathogenic fungi Fusarium graminearum and F. culmorum. These and other closely related fungi cause a disease known as Fusarium head blight (FHB) in small grain cereals.
Stephen N. Wegulo
doaj   +1 more source

Comparative analysis of content and composition of essential oils of Thymus vulgaris L. from different regions of Europe [PDF]

Proceedings of the Estonian Academy of Sciences
Common thyme (Thymus vulgaris L., Lamiaceae) is one of the most well-known plants in the world, widely used in medicine, culinary arts, and cosmetics. The aim of this study was to analyse the content and composition of essential oils (EO) obtained from ...
Ain Raal, Tetiana Gontova, Maie Palmeos, Anne Orav, Galiya Sayakova, Oleh Koshovyi   +5 more
doaj   +1 more source

Chemical Composition of Volatile Oils of Fresh and Air-Dried Buds of Cannabis hemovars, Their Insecticidal and Repellent Activities

Natural Product Communications, 2020
The volatile oils of fresh and air-dried buds of 3 different varieties of Cannabis, namely, high cannabidiol (CBD) chemotype, intermediate CBD/tetrahydrocannabinol (THC) chemotype, and high THC chemotype were prepared by hydrodistillation.
Amira S. Wanas, Mohamed M. Radwan, Suman Chandra, Hemant Lata, Zlatko Mehmedic, Abbas Ali, KHC Baser, Betul Demirci, Mahmoud A. ElSohly   +8 more
doaj   +1 more source

Authenticating the geographic origins of Atractylodes lancea rhizome chemotypes in China through metabolite marker identification

Frontiers in Plant Science, 2023
IntroductionAtractylodes lancea is widely distributed in East Asia, ranging from Amur to south-central China. The rhizome of A. lancea is commonly used in traditional Chinese medicine, however, the quality of products varies across different regions with
Chengcai Zhang, Hongyang Wang, Chaogeng Lyu, Yiheng Wang, Jiahui Sun, Yan Zhang, Zengxu Xiang, Xiuzhi Guo, Yuefeng Wang, Ming Qin, Sheng Wang, Sheng Wang, Lanping Guo   +12 more
doaj   +1 more source