Results 41 to 50 of about 11,582 (221)

Structural and Functional Siderophore Remodeling by Enzymatic Delipidation

Angewandte Chemie, EarlyView.
A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog, Keishi Ishida, Evelyn M. Molloy, Ron Hermenau, Kirstin Scherlach, Christian Hertweck   +5 more
wiley   +2 more sources

Crop Yield and Essential Oil Composition of Two Thymus vulgaris Chemotypes along Three Years of Organic Cultivation in a Hilly Area of Central Italy

Molecules, 2021
Thymus vulgaris L. is one of the most commonly used medicinal and aromatic plants (MAPs), owing to a range of therapeutic properties of its essential oil.
Basma Najar, Luisa Pistelli, Benedetta Ferri, Luciana Gabriella Angelini, Silvia Tavarini   +4 more
doaj   +1 more source

Discrimination of Fennel Chemotypes Applying IR and Raman Spectroscopy: Discovery of a New γ-Asarone Chemotype

Journal of Agricultural and Food Chemistry, 2014
Various vibrational spectroscopy methods have been applied to classify different fennel chemotypes according to their individual profile of volatile substances. Intact fennel fruits of different chemotypes could be successfully discriminated by attenuated total reflectance Fourier transform infrared (ATR-FTIR) and near infrared (NIR) spectroscopy ...
Krähmer, Andrea, Gudi, Gennadi, Krüger, Hans, Henning, Lothar, Schulz, Hartwig   +4 more
openaire   +3 more sources

Direct Regioselective para‐Fluorination via I(I)/I(III) Catalysis

Angewandte Chemie, EarlyView.
A direct, para‐selective fluorination by I(I)/I(III) catalysis is disclosed that does not require substrate pre‐functionalization. This strategy leverages the Leonard link inherent to phenylpropanoate and phenylpropanamides to promote a spirocyclization/para‐selective sequence. The C3‐side chain maps onto a range of common drug scaffolds and allows the
Christoph Roblick, Julian D. Bendix, Timothy A. Hilton, Kathrin Bussmann, Constantin G. Daniliuc, Ryan Gilmour   +5 more
wiley   +2 more sources

Underexplored Catalysts as General Structures: Application of Machine Learning Techniques for Reaction‐Specific Datasets

Angewandte Chemie, EarlyView.
Bias‐aware machine learning identified an underexplored imidazolidinone catalyst with broad competitive performance in iminium‐based reactions. Experimental benchmarking shows how data‐driven prioritization can uncover overlooked catalyst scaffolds from sparse and historically biased literature data.
Jiajing Li, Isaiah O. Betinol, Junshan Lai, Soresu Juyo, Jolene P. Reid   +4 more
wiley   +2 more sources

Spike culture derived wheat (Triticum aestivum L.) variants exhibit improved resistance to multiple chemotypes of Fusarium graminearum.

PLoS ONE, 2019
Fusarium head blight (FHB) in wheat (Triticum aestivum L.), predominantly caused by Fusarium graminearum, has been categorized into three chemotypes depending on the major mycotoxin produced. The three mycotoxins, namely, 3-acetyldeoxynivalenol (3-ADON),
Chen Huang, Manu P Gangola, Seedhabadee Ganeshan, Pierre Hucl, H Randy Kutcher, Ravindra N Chibbar   +5 more
doaj   +1 more source

Variations in the Chemical Composition of Essential Oils in Native Populations of Korean Thyme, Thymus quinquecostatus Celak.

Molecules, 2022
The genus Thymus (Lamiaceae) contains numerous medicinally important species. Among them, Thymus quinquecostatus Celak. has been extensively utilized as a traditional medicine and a food flavoring agent in the Korean peninsula, owing to its unique aroma.
Minju Kim, Kandhasamy Sowndhararajan, Ponnuvel Deepa, Songmun Kim   +3 more
doaj   +1 more source

A Comprehensive 19F NMR Framework for Fragment‐Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR

Angewandte Chemie, EarlyView.
NMR screening is a powerful method for hit detection in drug‐discovery. We designed and validated the OpenFL600 19F$^{19}{\rm F}$ NMR library to probe diverse targets, including RNA, GPCRs, kinases, and proteases. This library yields target‐specific ligands without generating promiscuous binders.
Simon H. Rüdisser, Gabriela Stadler, Giacomo Padroni, Daria Barbash, Marco M. Ruckstuhl, Nils Lorz, Christina Jordan, Sarah Skibinski, Timo T. Stühlinger, Sarah E. Kratzwald, Katharina M. Siess, Sven Brüschweiler, Gerald Platzer, Antoine Cléry, Robert Konrat, Frédéric H.‐.T. Allain, Alvar D. Gossert   +16 more
wiley   +2 more sources

Influence of Abiotic Factors on the Phytochemical Profile of Two Species of Artemisia: A. herba alba Asso and A. mesatlantica Maire

International Journal of Plant Biology, 2022
The species of Artemisia are well known in the Mediterranean region, especially in Morocco, for their traditional uses and health benefit. In this study, we were interested in two species of Artemisia, namely A. herba alba Asso and A. mesatlantica Maire.
Sanae Amine, Mohamed Bouhrim, Hamza Mechchate, Atika Ailli, Mohamed Radi, Sevser Sahpaz, Smail Amalich, Malika Mahjoubi, Touriya Zair   +8 more
doaj   +1 more source

Diversity of Peptides Produced by Nodularia spumigena from Various Geographical Regions

Marine Drugs, 2012
Cyanobacteria produce a great variety of non-ribosomal peptides. Among these compounds, both acute toxins and potential drug candidates have been reported. The profile of the peptides, as a stable and specific feature of an individual strain, can be used
Lisa Spoof, Reyhan Akcaalan, Agata Blaszczyk, Monika J. Kaczkowska, Hanna Mazur-Marzec, Jussi Meriluoto   +5 more
doaj   +1 more source