Results 51 to 60 of about 11,582 (221)
Agronomy, 2020 The current study aimed to assess the allelopathic effect of Rosmarinus officinalis L. essential oils (EOs) to define the potent effect against weed species, by exploring distinct chemotypes and their main compounds.
Jihane El Mahdi +5 more
doaj +1 more source
Advanced Science, EarlyView.Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn +20 more
wiley +1 more source
Advanced Science, EarlyView.We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang +13 more
wiley +1 more source
Molecules, 2018 The Verbenaceae family includes 2600 species grouped into 100 genera with a pantropical distribution. Many of them are important elements of the floras of warm-temperature and tropical regions of America.
Cristina M. Pérez Zamora +2 more
doaj +1 more source
A new chemotype with promise against Trypanosoma cruzi [PDF]
Bioorganic & Medicinal Chemistry Letters, 2020 Pyridyl benzamide 2 is a potent inhibitor of Trypanosoma cruzi, but not other protozoan parasites, and had a selectivity-index of ≥10. The initial structure-activity relationship (SAR) indicates that benzamide and sulfonamide functional groups, and N-methylpiperazine and sterically unhindered 3-pyridyl substructures are required for high activity ...
Wang, X. +8 more
openaire +4 more sources
Advanced Science, EarlyView.A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker +11 more
wiley +1 more source
Chemical constituents of sea buckthorn (Hippophae rhamnoides L.) fruit in populations of central Alborz Mountains in Iran [PDF]
Research Journal of Pharmacognosy, 2017 Background and objectives: Hippophae rhamnoides L. known as sea buckthorn is a deciduous medicinal shrub belonging to Elaeagnaceae family. In this study, the most important chemical constituents of sea buckthornwere evaluated in wild populations of ...
A. Kuhkheil +3 more
doaj
Medicines, 2017 Background: Avicennia schaueriana Stapf & Leechm. ex Moldenke (Acanthaceae) is a native species from the Brazilian mangroves presenting ecological and economic significance.
Kamilla N. Machado +5 more
doaj +1 more source
What is a plant chemotype, anyway?
Trends in Plant ScienceMany plant species show chemical polymorphisms regarding the composition of specialized metabolites belonging to certain chemical families. This led to the classification of chemotypes, that is, groups of plants that can be distinguished by their chemical profiles of metabolites within one chemical family. We present existing definitions and approaches
Müller, Caroline +2 more
openaire +1 more source
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source