Results 51 to 60 of about 15,517 (273)

Secondary Site Ligand for Integrin αVβ3 Enables Targeted mRNA Delivery

Angewandte Chemie, EarlyView.
Non‐orthosteric, low‐affinity ligands for integrin αVβ3, identified by fragment screening, achieve superselective nanoparticle targeting (ακ ≈ 3) of αVβ3‐overexpressing endothelial cells. Unlike traditional arginine–glycine–aspartate decorated particles, these fragment‐functionalized LNPs discriminate cells by receptor density and deliver mRNA to ...
Sebastian Bayer, María García‐García, Raffaele Senatore, Maria Stratoudaki, Alina Markhof, Angelika Berger‐Becvar, Anna Sophia Parianou, Christoph Rademacher   +7 more
wiley   +2 more sources

Crop Yield and Essential Oil Composition of Two Thymus vulgaris Chemotypes along Three Years of Organic Cultivation in a Hilly Area of Central Italy

Molecules, 2021
Thymus vulgaris L. is one of the most commonly used medicinal and aromatic plants (MAPs), owing to a range of therapeutic properties of its essential oil.
Basma Najar, Luisa Pistelli, Benedetta Ferri, Luciana Gabriella Angelini, Silvia Tavarini   +4 more
doaj   +1 more source

Spike culture derived wheat (Triticum aestivum L.) variants exhibit improved resistance to multiple chemotypes of Fusarium graminearum.

PLoS ONE, 2019
Fusarium head blight (FHB) in wheat (Triticum aestivum L.), predominantly caused by Fusarium graminearum, has been categorized into three chemotypes depending on the major mycotoxin produced. The three mycotoxins, namely, 3-acetyldeoxynivalenol (3-ADON),
Chen Huang, Manu P Gangola, Seedhabadee Ganeshan, Pierre Hucl, H Randy Kutcher, Ravindra N Chibbar   +5 more
doaj   +1 more source

Variations in the Chemical Composition of Essential Oils in Native Populations of Korean Thyme, Thymus quinquecostatus Celak.

Molecules, 2022
The genus Thymus (Lamiaceae) contains numerous medicinally important species. Among them, Thymus quinquecostatus Celak. has been extensively utilized as a traditional medicine and a food flavoring agent in the Korean peninsula, owing to its unique aroma.
Minju Kim, Kandhasamy Sowndhararajan, Ponnuvel Deepa, Songmun Kim   +3 more
doaj   +1 more source

HTS-Driven Discovery of New Chemotypes with West Nile Virus Inhibitory Activity

Molecules, 2010
West Nile virus (WNV) is a positive sense, single-stranded RNA virus that can cause illness in humans when transmitted via mosquito vectors. Unfortunately, no antivirals or vaccines are currently available, and therefore efficient and safe antivirals are
Qianjun Li, Shuang Feng, Marintha Heil, E. Lucile White, Subramaniam Ananthan, Blake. P. Moore, Sara N. McKellip, Clinton Maddox, Colleen B. Jonsson, Dong Hoon Chung, Lynn Rasmussen   +10 more
doaj   +1 more source

Influence of Abiotic Factors on the Phytochemical Profile of Two Species of Artemisia: A. herba alba Asso and A. mesatlantica Maire

International Journal of Plant Biology, 2022
The species of Artemisia are well known in the Mediterranean region, especially in Morocco, for their traditional uses and health benefit. In this study, we were interested in two species of Artemisia, namely A. herba alba Asso and A. mesatlantica Maire.
Sanae Amine, Mohamed Bouhrim, Hamza Mechchate, Atika Ailli, Mohamed Radi, Sevser Sahpaz, Smail Amalich, Malika Mahjoubi, Touriya Zair   +8 more
doaj   +1 more source

Development of a generic PCR detection of deoxynivalenol- and nivalenol-chemotypes of Fusarium graminearum

, 2005
Based on the intergenic sequences of Tri5¿Tri6 genes involved in the mycotoxin pathways of Fusarium species, a generic PCR assay was developed to detect a 300 bp fragment of deoxynivalenol (DON)-chemotypes and a 360 bp sequence of nivalenol (NIV ...
Scholten, O.E., Li, H.P., Liao, Y.C., Zhao, C.S., Wu, A.B., Löffler, H.J.M.   +5 more
core   +1 more source

Bio-Herbicidal Potential of the Essential Oils from Different Rosmarinus officinalis L. Chemotypes in Laboratory Assays

Agronomy, 2020
The current study aimed to assess the allelopathic effect of Rosmarinus officinalis L. essential oils (EOs) to define the potent effect against weed species, by exploring distinct chemotypes and their main compounds.
Jihane El Mahdi, Waed Tarraf, Claudia Ruta, Lea Piscitelli, Adel Aly, Giuseppe De Mastro   +5 more
doaj   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Diversity of Peptides Produced by Nodularia spumigena from Various Geographical Regions

Marine Drugs, 2012
Cyanobacteria produce a great variety of non-ribosomal peptides. Among these compounds, both acute toxins and potential drug candidates have been reported. The profile of the peptides, as a stable and specific feature of an individual strain, can be used
Lisa Spoof, Reyhan Akcaalan, Agata Blaszczyk, Monika J. Kaczkowska, Hanna Mazur-Marzec, Jussi Meriluoto   +5 more
doaj   +1 more source