Results 71 to 80 of about 11,582 (221)

4′‐ThioRNA Substitution and Sense‐Strand Segmentation for the Design of Functional Fully Modified siRNAs Targeting SARS‐CoV‐2

Chemistry – A European Journal, EarlyView.
4′‐ThioRNA was broadly tolerated across multiple positions in SARS‐CoV‐2‐targeting siRNAs, but full 4'‐thio modification of both strands caused a reduction in RNAi activity. Sense‐strand segmentation improved RNAi and antiviral activity, particularly when the nick was located at position 10 from the 5′‐end of the sense strand, thereby unlocking the ...
Yuhei Nogi, Jun Tsukimoto, Noriko Saito‐Tarashima, Takaaki Koma, Masako Nomaguchi, Noriaki Minakawa   +5 more
wiley   +1 more source

Phytochemical Composition and Bioactivity of Elsholtzia strobilifera (Benth.) Benth Essential Oil With Spectral Characterisation of Pinocarvone Using NMR Techniques

Flavour and Fragrance Journal, EarlyView.
Elsholtzia strobilifera (Benth.) EO: in‐depth chemical and biological investigation. ABSTRACT Species of the genus Elsholtzia (Lamiaceae) have been traditionally used in folk medicine and are known for their diverse biological properties. However, the chemical composition and bioactivity of the essential oil from Elsholtzia strobilifera (Benth.) Benth.
Priyanka Bhatt, Pooja Bargali, Gunja Sah, G. C. Shah, Ravendra Kumar, Stefania Garzoli, Maneesha Pathak, Archana N. Sah   +7 more
wiley   +1 more source

Integrated characterization of Greek fennel genotypes through morpho‐agronomical characteristics, yield components and phytochemical compounds

JSFA reports, Volume 5, Issue 3, Page 91-103, March 2025.
Abstract Background Fennel (Foeniculum vulgare Mill.) is a widely cultivated vegetable and aromatic‐medicinal plant. In this research, field studies assessed 12 fennel genotypes of diverse origin, comprising 10 Greek accessions and two European commercial varieties, focusing on their morpho‐agronomical traits, phenolic compounds and antioxidant ...
Kalliopi I. Kadoglidou, Christos Maliachovas, Parthenopi Ralli, Maria Irakli, Nektaria Tsivelika, Athanasios G. Mavromatis, Paschalina Chatzopoulou   +6 more
wiley   +1 more source

COMPARATIVE STUDY OF THE CHEMICAL COMPOSITION OF AMAPA LATEX FROM Parahancornia amapa AND Brosimum parinarioides BY HPLC-UV-DAD

Química Nova
A phytochemical study of the latex from P. amapa and B. parinarioides has led to the isolation of nine compounds. From the latex of B. parinarioides, six compounds were isolated: lupeol acetate (1), butyrospermol (2), and its epimer, tirucalla-7,24-dien ...
Rita Cynara de Oliveira Salles, Sergio Massayoshi Nunomura, Norberto Peporine Lopes, Rita de Cássia Saraiva Nunomura   +3 more
doaj   +1 more source

Review of phytochemical and antioxidant properties of Ethiopian medicinal plants

JSFA reports, EarlyView.
Abstract Ethiopia possesses a rich ethnobotanical heritage and diverse medicinal flora that play an important role in traditional healthcare. Many Ethiopian medicinal plants contain bioactive phytochemicals with potential antioxidant properties. This capital of indigenous knowledge has contributed to the documentation of different medicinal plants that
Endalamaw Yihune, Amare Bitew Mekonnen, Getahun Yemata   +2 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

chemotype

Citation: 'chemotype' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13001 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Distinction and Pharmacological Activity of Monoterpenes and Sesquiterpenes in Different Chemotypes of Cinnamomum camphora (L.) Presl

Applied Sciences
Cinnamomum camphora (L.) Presl, a perennial evergreen tree of the Lauraceae family, exhibits diverse chemotypes and abundant essential oil constituents, which are widely utilized in pharmaceuticals, perfumery, and fine chemicals.
Zhangxiang Min, Bingsong Zheng, Daoliang Yan   +2 more
doaj   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source