Results 71 to 80 of about 17,521 (222)

Potential Anti-Infectious Activity of Essential Oil Chemotypes of Lippia origanoides Kunth on Antibiotic-Resistant Staphylococcus aureus Strains

Plants
Staphylococcus aureus infections are prevalent in healthcare and community environments. Methicillin-resistant S. aureus is catalogued as a superbug of high priority among the pathogens.
Andrés Humberto Uc-Cachón, Luz María Calvo-Irabien, Angel de Jesús Dzul-Beh, Haziel Eleazar Dzib-Baak, Rosa Grijalva-Arango, Gloria María Molina-Salinas   +5 more
doaj   +1 more source

Trends and Future Directions in Organic Chemistry for Drug Discovery

Chemistry – A European Journal, EarlyView.
Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
wiley   +1 more source

Chemical composition and antimicrobial properties of different basil essential oils chemotypes from Togo [PDF]

, 2008
The aerial parts essential oils of Ocimum basilicum (Lamiaceae) from Togo were steam-distilled and investigated for their percentage composition (GC and GC/MS) and in vitro antimicrobial activities.
Koba, Koffi, Poutouli, P.W., Sanda, Komla, Chaumont, Jean-Pierre, Koffi Koba, P.W. Poutouli, Komla Sanda, Raynaud, Christine, Christine Raynaud, Jean-Pierre Chaumont, P. W. Poutouli   +10 more
core   +1 more source

Selective N‐Functionalization of Pyrazoles

European Journal of Organic Chemistry, EarlyView.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek, Matthias Schrader, Christopher J. Teskey   +2 more
wiley   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Phytochemical Composition and Bioactivity of Elsholtzia strobilifera (Benth.) Benth Essential Oil With Spectral Characterisation of Pinocarvone Using NMR Techniques

Flavour and Fragrance Journal, EarlyView.
Elsholtzia strobilifera (Benth.) EO: in‐depth chemical and biological investigation. ABSTRACT Species of the genus Elsholtzia (Lamiaceae) have been traditionally used in folk medicine and are known for their diverse biological properties. However, the chemical composition and bioactivity of the essential oil from Elsholtzia strobilifera (Benth.) Benth.
Priyanka Bhatt, Pooja Bargali, Gunja Sah, G. C. Shah, Ravendra Kumar, Stefania Garzoli, Maneesha Pathak, Archana N. Sah   +7 more
wiley   +1 more source

Evaluation of the Toxicity, Morphological and Behavioural Effects of Pelargonium graveolens Essential Oil in Artemia franciscana, Along With Its Antimicrobial Activity

Flavour and Fragrance Journal, EarlyView.
Essential oil of Pelargonium graveolens exhibited potent antimicrobial activity against bacterial and fungal pathogens, while higher concentrations induced mortality and altered swimming behaviour in Artemia franciscana. These findings highlight its therapeutic potential and underscore the importance of defining safe concentration ranges to support ...
Silvana de Oliveira, Caio Alexandre de Freitas Schatzer, Tiago Schena, Fernanda Dias da Silva, Elizabeth Teodorov   +4 more
wiley   +1 more source

Selective herbivory of thyme chemotypes by a mollusk and a grasshopper

, 1999
The common thyme (Thymus vulgaris, Labiatae) is biochemically variable, and in southern France individual plants belong to one of six chemotypes defined by the presence of specific monoterpenes.
Linhart, Yan B., Thompson, John D., Yan B. Linhart, John D. Thompson, Parry, Jean-Marc, Chaouni-Benabdallah, Loubna, Jean-Marc Parry, Loubna Chaouni-Benabdallah   +7 more
core   +1 more source

Phytochemistry, Chemotypic Diversity and Antimicrobial Potential of Essential Oils From Native Aromatic Plants of the Americas: A Systematic Review

Flavour and Fragrance Journal, EarlyView.
This review bridges ancestral indigenous knowledge with modern pharmacology, summarizing the phytochemistry and antimicrobial properties of essential oils from seven native American species. It highlights their significant activity against bacterial, fungal and parasitic pathogens, emphasizing their potential as sustainable therapeutic and agricultural
Arley Rey Páez, Mozaniel Santana de Oliveira, João Paulo Viana Leite   +2 more
wiley   +1 more source

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor [PDF]

, 2017
The ongoing epidemics of opioid overdose raises an urgent need for effective antiaddiction therapies and addiction-free painkillers. The κ-opioid receptor (KOR) has emerged as a promising target for both indications, raising demand for new chemotypes of ...
Huang, Xi-Ping, Chen, Xin, Stevens, Raymond C., Roth, Bryan L., Zou, Rodger, Mangano, Thomas J., Katritch, Vsevolod, Zheng, Zhong, Zaidi, Saheem A.   +8 more
core   +1 more source