Results 81 to 90 of about 24,382 (256)

In depth investigation of the metabolism of Nectandra megapotamica chemotypes. [PDF]

PLoS ONE, 2018
Plants produce a wide range of secondary metabolites. Within a single species, chemotypes can be distinguished by the differences in the composition of the secondary metabolites.
Katyuce de S Farias, Thierry Delatte, Rosani do C de O Arruda, Flavio M Alves, Denise B Silva, Jules Beekwilder, Carlos A Carollo   +6 more
doaj   +1 more source

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. [PDF]

, 2016
The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the
Kärkäs, Markus D., Porco, John A., Stephenson, Corey R.J.   +2 more
core   +2 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Diversity of Sweet Basil Accessions from Croatian National Plant Gene Bank Based on Amplified Fragment Length Polymorphism Markers

Agronomy
This study investigates genetic diversity among five morphotypes and five chemotypes of Ocimum basilicum L. (sweet basil) using amplified fragment length polymorphism (AFLP) markers.
Filip Varga, Monika Vidak, Zlatko Liber, Klaudija Carović-Stanko, Zlatko Šatović   +4 more
doaj   +1 more source

Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen. [PDF]

PLoS Neglected Tropical Diseases, 2009
Patients with clinical manifestations of leishmaniasis, including cutaneous leishmaniasis, have limited treatment options, and existing therapies frequently have significant untoward liabilities.
Elizabeth R Sharlow, David Close, Tongying Shun, Stephanie Leimgruber, Robyn Reed, Gabriela Mustata, Peter Wipf, Jacob Johnson, Michael O'Neil, Max Grögl, Alan J Magill, John S Lazo   +11 more
doaj   +1 more source

Detailed phytochemical analysis of high- and low artemisinin-producing chemotypes of Artemisia annua [PDF]

, 2018
Chemical derivatives of artemisinin, a sesquiterpene lactone produced by Artemisia annua, are the active ingredient in the most effective treatment for malaria. Comprehensive phytochemical analysis of two contrasting chemotypes of A.
Acton, Anke, Arsenault, Bouwmeester, Brown, Brown, Brown, Bylesjö, Czechowski, Delabays, Duke, Duke, Ferreira, Ferreira, Graham, Guha, Kuhl, Larson, Lommen, Mercke, Nguyen, Niu, Olsson, Paddon, Ro, Ruijter, Santomauro, Shen, Smith, Soetaert, Stacklies, Sy, Tautenhahn, Teoh, Teoh, Ting, Wallaart, Wallaart, Wetzstein, Woerdenbag, Yamazaki, Yang, Yuan, Zhang   +43 more
core   +3 more sources

Transport engineering as a strategy to realize rapeseed's potential as a protein‐rich food

Pest Management Science, EarlyView.
The heavily pesticide‐dependent rapeseed is an under‐utilized protein source for food owing to anti‐nutritional glucosinolates. Transport engineering technology may reduce glucosinolates in seeds while increasing defense in vegetative parts. Abstract Rapeseed is the world's second‐largest oilseed crop, and the low‐value press cake that remains after ...
Jakob Skytte Thorsen, Deyang Xu, Barbara Ann Halkier   +2 more
wiley   +1 more source

Potential Anti-Infectious Activity of Essential Oil Chemotypes of Lippia origanoides Kunth on Antibiotic-Resistant Staphylococcus aureus Strains

Plants
Staphylococcus aureus infections are prevalent in healthcare and community environments. Methicillin-resistant S. aureus is catalogued as a superbug of high priority among the pathogens.
Andrés Humberto Uc-Cachón, Luz María Calvo-Irabien, Angel de Jesús Dzul-Beh, Haziel Eleazar Dzib-Baak, Rosa Grijalva-Arango, Gloria María Molina-Salinas   +5 more
doaj   +1 more source

Scaffold Diversity of Fungal Metabolites [PDF]

, 2017
Many drug discovery projects rely on commercial compounds to discover active leads. However, current commercial libraries, with mostly synthetic compounds, access a small fraction of the possible chemical diversity. Natural products, in contrast, possess
Cedric J. Pearce, John R. Owen, José L. Medina-Franco, Mariana González-Medina, Mario Figueroa, Nicholas H. Oberlies, Tamam El-Elimat   +6 more
core   +1 more source

How does leaf age affect performance? A comparative study of essential oils from young and mature Eucalyptus globulus leaves in crop protection

Pest Management Science, EarlyView.
Leaf age influences metabolomic profiling but not bioactivity of Eucalyptus globulus essential oils. Leaf age affects volatile levels of young and adult E. globulus oils, but not their bioactivity. Young leaf essential oil had higher contents of α‐ and β‐pinene. AEEO had higher levels of 1,8‐cineole and trans‐pinocarveol.
Mafalda Pinto, Cristiano Soares, Ana Cristina Figueiredo, Joana Neto, Pedro A S Sousa, Ana A R M Aguiar, Michele Narduzzi, Chiara Antonelli, Anna Maria Vettraino, Tatiana Andreani, Fernando Tavares, Fernanda Fidalgo   +11 more
wiley   +1 more source