Results 91 to 100 of about 17,521 (222)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Differences in lipids and antibacterial activities among three chemotypes of

Food Chemistry: X
Medium-chain triacylglycerols confer health benefits to humans by virtue of their medium-chain fatty acids (MCFAs). To promote the utilization of different chemotypes of Cinnamomum camphora seed lipids in food industry, we investigated the seed ...
Zhenyuan Wang, Fangyou Peng, Haozhe Xu, Xintao Wu, Zhaojiang Zuo   +4 more
doaj   +1 more source

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

Table_12_Analysis of chemotypes and their markers in leaves of core collections of Eucommia ulmoides using metabolomics.xlsx

, 2023
The leaves of Eucommia ulmoides contain various active compunds and nutritional components, and have successively been included as raw materials in the Chinese Pharmacopoeia, the Health Food Raw Material Catalogue, and the Feed Raw Material Catalogue ...
Hongyan Du (305605), Yide Meng (8602965), Panfeng Liu (14348814), Qingxin Du (14348811), Qi Wang (22418), Lu Wang (45927), Lanying Du (290113)   +6 more
core   +1 more source

When alien plants become health hazards: An applied study on toxic and allergenic risks in Italy

PLANTS, PEOPLE, PLANET, EarlyView.
Alien plants are often studied for their ecological harm, but their risks to human and animal health remain poorly documented. This study provides the first comprehensive catalogue of poisonous and allergenic alien plants in Italy, identifying which species are dangerous, where they grow and who is most at risk—from children in city parks to pets and ...
Giulio Barone, Gianniantonio Domina, Giuseppe Venturella, Emilio Di Gristina   +3 more
wiley   +1 more source

Chemotyping of Fusarium graminearum using Tri13 trichothecene biosynthetic gene

Journal of Crop Protection, 2013
Fusarium graminearum is one of the most important causes of FHB or wheat scab in different part of the world. This fungus is able to produce widespread Trichothecene mycotoxins such as Nivalenol (NIV) and Deoxynivalenol (DON) which are harmful for both ...
Mostafa Abedi-Tizaki, Seyed Kazem Sabbagh, Mahta Mazaheri Naeini, Saedeh Sepehrikia   +3 more
doaj  

Thymus pulegioides chemotypes in Lithuania: distribution, influence of edaphic and climatic factors, allelopathic characteristics. [PDF]

, 2018
The regularities of the distribution of different chemotypes of large thyme (Thymus pulegioides) in Lithuania, influence of edaphic and climatic factors on quantitative and qualitative composition of essential oils, as well as allelopathic and ...
Vaičiulytė, Vaida,
core  

Transport engineering as a strategy to realize rapeseed's potential as a protein‐rich food

Pest Management Science, EarlyView.
The heavily pesticide‐dependent rapeseed is an under‐utilized protein source for food owing to anti‐nutritional glucosinolates. Transport engineering technology may reduce glucosinolates in seeds while increasing defense in vegetative parts. Abstract Rapeseed is the world's second‐largest oilseed crop, and the low‐value press cake that remains after ...
Jakob Skytte Thorsen, Deyang Xu, Barbara Ann Halkier   +2 more
wiley   +1 more source

Endophytic fungi from two isolated Bethencourtia palmensis populations: metabolomic and bioactivity fingerprinting

Pest Management Science, EarlyView.
We compared two island populations of Bethencourtia palmensis and their culturable endophytic fungi, revealing distinct plant chemistries and a higher biopesticidal potential in the endophytic fungi from La Palma population along with high potential for the discovery of novel compounds.
Jorge Rojas López‐Menchero, Juan Imperial, Carmen Elisa Díaz, María Fe Andrés, Azucena González‐Coloma   +4 more
wiley   +1 more source

In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action

Pest Management Science, EarlyView.
In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action. Cinmethylin inhibits FATs, disrupting eukaryotic de novo lipid biosynthesis and causing defects in cell division, elongation and integrity. We confirm FATs as the primary site of action in planta.
Maximillian Pollmeier, Aisha Gerhardt, Janneke Hendriks, Katharina Kaprocki, Alexandra Zimmermann, Sarina Ruehm, Martina Marnet, Maria Stroe, Jorge Alfredo Rojas Biava, Clara Hofmann, Michael Betz, Sascha Schlaefer, Philipp Ternes, Jens Lerchl, Selene Garcia‐Hernandez, Philipp Johnen   +15 more
wiley   +1 more source