Results 111 to 120 of about 17,521 (222)
The chemical compositions of three chemotypes of Ravensara aromatica Sonn. (Lauraceae) leaf essential oils (EOs) was determined by GC and GC/MS. One chemotype rich in aromatic components (methyl chavicol) and two chemotypes rich in terpenic components ...
Andrianjafinandrasana, S.N. +4 more
core
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disease, and cholinergic dysfunction is considered one of the fundamental pathological factors of this disease. Guided by the clinically used acetylcholinesterase (AChE) inhibitor donepezil, we explored trimetazidine dihydrochloride as an accessible starting scaffold to generate ...
Muhammed Oğuzhan Doğan +6 more
wiley +1 more source
Structures of chemotypes 1a and 2a and their respective deuterated forms examined in this study.
Structures of chemotypes 1a and 2a and their respective deuterated forms examined in this study.
Alfin D. N. Vaz (172262) +8 more
core +1 more source
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Phyto-chemotypes identified in the methanol root extract of R. imbricata by GC/MS.
Phyto-chemotypes identified in the methanol root extract of R. imbricata by GC/MS.
Rajinder S. Chauhan (178024) +6 more
core +1 more source
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu +2 more
wiley +1 more source
Phyto-chemotypes identified in the dichloroethane root extract of R. imbricata by GC/MS.
Phyto-chemotypes identified in the dichloroethane root extract of R. imbricata by GC/MS.
Rajinder S. Chauhan (178024) +6 more
core +1 more source
Combating Campylobacter Resistance in Moroccan Poultry Using Essential Oil–Ciprofloxacin Combination
With an estimated prevalence of 15.52% in Moroccan poultry, Campylobacter species pose a significant food safety concern. We investigated whether essential oils (EOs) could restore the efficacy of ciprofloxacin against multidrug‐resistant (MDR) strains.
Zineb Soubai +13 more
wiley +1 more source
Optimal growing temperatures varied with mountain pine beetle‐associated fungal species. There was only a marginal impact of temperature on the response of fungi to defensive monoterpenes of novel host pine. Interspecific facilitation occurred for Leptiographuim longiclavatum when grown in Ophiostoma montium‐induced treatments at optimal temperatures ...
Adrienne C. Bailey +4 more
wiley +1 more source

