Results 131 to 140 of about 15,517 (273)
What is a plant chemotype anyway?
Many plant species show chemical polymorphisms regarding the composition of specialized metabolites belonging to certain chemical families. This led to the classification of chemotypes, that is, groups of plants that can be distinguished by their chemical profiles of metabolites within one chemical family. We present existing definitions and approaches
Caroline Müller +2 more
openaire +1 more source
, 2018 The regularities of the distribution of different chemotypes of large thyme (Thymus pulegioides) in Lithuania, influence of edaphic and climatic factors on quantitative and qualitative composition of essential oils, as well as allelopathic and ...
Vaičiulytė, Vaida,
core
Phyto-chemotypes identified in the chloroform root extract of R. imbricata by GC/MS.
, 2013 Phyto-chemotypes identified in the chloroform root extract of R. imbricata by GC/MS.
Rajinder S. Chauhan (178024) +6 more
core +1 more source
Plant Biotechnology Journal, Volume 24, Issue 7, Page 4528-4545, July 2026.ABSTRACT Protoberberine alkaloids are a characteristic group of natural products in Coptis plants known for their notable pharmacological activities. However, the structural similarity and the substrate promiscuity of their biosynthetic enzymes have left the precise synthetic pathways remain unclarified, posing challenges to regulate product formation.
Jun Song +14 more
wiley +1 more source
Chemistry – A European Journal, Volume 32, Issue 24, 23 June 2026.A modular Rh‐catalyzed synthetic approach enabled the preparation of diverse reactive fragments from available substrates. The reactive fragments modified Aurora A kinase via several distinct modification reaction classes. In a complex biological environment, the constellation of modified proteins depended critically on the reactive fragment structure.
Julian Chesti +8 more
wiley +1 more source
Inheritance and covariation of specialised metabolites among cannabis chemotypes
The major phytocannabinoid bioactives produced by Cannabis sativa L. (cannabis) are Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), with many minor phytocannabinoids (PCs) also thought to contribute to the pharmacological efficacy.
Matthew Welling (9491627) +7 more
core +1 more source
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Screening a lysine‐targeting covalent fragment library against challenging protein targets revealed suitable warheads and characterized binding sites for the development of targeted covalent ligands. Covalent fragment screening has become an established strategy for identifying targetable amino acid residues or viable chemical starting points against ...
Noémi Csorba +18 more
wiley +1 more source
Development of a Brain‐Penetrant Nurr1 Agonist Tool
ChemMedChem, Volume 21, Issue 11, 15 June 2026.Nuclear receptor‐related 1 (Nurr1) is a ligand‐activated transcription factor with neuroprotective properties, thought to hold therapeutic potential in neurodegeneration. Here, we developed a potent, brain‐penetrant Nurr1 agonist to study the effects of pharmacological Nurr1 activation in the CNS in vivo. The ligand‐sensing transcription factor nuclear
Jan Vietor +7 more
wiley +1 more source
Phyto-chemotypes identified in the dichloroethane root extract of R. imbricata by GC/MS.
, 2013 Phyto-chemotypes identified in the dichloroethane root extract of R. imbricata by GC/MS.
Rajinder S. Chauhan (178024) +6 more
core +1 more source
Probing 3‐Amino‐2H‐Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2
ChemMedChem, Volume 21, Issue 11, 15 June 2026.A palladium‐catalyzed domino reaction facilitated the discovery and rapid synthesis of selective, potent 3‐amino‐2H‐azaindazole derivatives serving as allosteric inhibitors of SHP2. Structural analysis via co‐crystallography confirmed binding at the allosteric site, thereby stabilizing the autoinhibited SHP2 conformation, qualifying this scaffold as a ...
Machoud Amoussa +20 more
wiley +1 more source