Results 141 to 150 of about 24,382 (256)
ChemBang: Expanding the Chemical Space Around Small Molecules
Molecular Informatics, Volume 45, Issue 5, May 2026.Schematic diagram of the underlying concepts behind ChemBang and the molecular generation process from a seed molecular structure by applying the three main categories of chemical transformations, namely, interchange of small substituents, replacement of ring systems, and scaffold enlargement by additional ring systems.
Diana Montes‐Grajales +3 more
wiley +1 more source
The Structure of the Chemotype Determining Locus in Cannabis sativa
Plant Direct, Volume 10, Issue 5, May 2026.ABSTRACT The chemical phenotype (chemotype) of Cannabis sativa is defined by the ratio of cannabidiolic acid (CBDA) to Δ9‐tetrahydrocannabinolic acid (THCA). Although the Mendelian segregation of these traits suggests a single‐locus biallelic system, recent sequencing and phylogenetic evidence indicate they are encoded by two distinct, tightly linked ...
Keith Allen +2 more
wiley +1 more source
Medicinal plants growing in the Judea region: network approach for searching potential therapeutic targets [PDF]
, 2012 Plants growing in the Judea region are widely used in traditional medicine of the Levant region. Nevertheless, they have not so far been sufficiently analyzed and their medicinal potential has not been evaluated.
Arie Budovsky, Vadim E. Fraifeld
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Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.Adding mountain mint (Ziziphora clinopodioides Lam.) to diet of laying quails resulted in the production of elongated eggs, improved blood lipid profiles and immune responses. ABSTRACT Background Mountain mint (MM), a traditional herbal remedy, has garnered attention for its potential benefits on poultry health and productivity.
Ahmad Hassanabadi +2 more
wiley +1 more source
Acta Crystallographica Section D, Volume 82, Issue 5, Page 550-570, May 2026.This study investigates the mycobacterial membrane protein MmpL3, a key target for new antituberculosis drugs, by combining high‐resolution crystallography and computational simulations. It reveals how the inhibitor UPAR‐1109 binds to MmpL3, providing detailed insights into the function and flexibility of the protein and supporting the rational design ...
Satoshi Murakami +9 more
wiley +1 more source
European Pharmaceutical JournalThis study investigated the chemical diversity of essential oils (EOs) extracted from eight Mentha spicata samples collected across different regions of Iran.
Hemati Golsa +5 more
doaj +1 more source
Deciphering the biosynthetic pathways of lichen acids
New Phytologist, Volume 250, Issue 3, Page 1784-1799, May 2026.Summary Depsides and depsidones are polyketide‐derived lichen acids widely distributed in lichen thalli, yet the biosynthetic gene clusters (BGCs) responsible for their production remain poorly understood. To address this gap, we investigated the diversity and evolutionary relationships of polyketide BGCs in lichens.
Wonyong Kim +11 more
wiley +1 more source
Uniciencia[Objective] This study aimed to evaluate the antimicrobial efficacy of essential oil (EO) from diverse chemotypes of Lippia graveolens against oxytetracycline-resistant Aeromonas hydrophila, which primarily affects the tilapia aquaculture (O.
Josué García-Pérez +4 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 8, 28 April 2026.Discovery of imatinib–triazolopyrimidine hybrids with selective cytotoxicity and a mechanism distinct from classical BCR‐ABL1 inhibition. This bioisosteric strategy introduces a novel compounds, paving the way for innovative antileukemic therapies with differentiated profiles.
Stefany Castro Bazan Moura +10 more
wiley +1 more source
Structure‐ and Ligand‐Based Discovery of Novel 3‐Chymotrypsin‐Like Protease Nonpeptidomimetic Hits
ChemMedChem, Volume 21, Issue 7, 14 April 2026.A multistep virtual screening cascade, integrating shape‐based, ensemble docking, and quantitative structure–activity relationship (QSAR) models, was employed to screen 1.5 million compounds. This funnel identified a novel 3‐chymotrypsin‐like protease (3CLpro) inhibitor, LabMol‐499, which was experimentally validated using a Förster Resonance Energy ...
Sabrina Silva‐Mendonça +14 more
wiley +1 more source