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Diagnostic utility of real-time RT-PCR for chikungunya virus detection in the acute phase of infection: a retrospective study [PDF]

Annals of Medicine
Background Chikungunya fever is a viral disease spread by Aedes mosquitoes, reported in over 110 countries. In India, it was first detected in Kolkata in 1963 and is now widespread. Diagnosis often relies on detecting anti-chikungunya IgM antibodies, but
Anupama Sajith, Varsha Iyengar, Prasad Varamballi, Chiranjay Mukhopadhyay, Sudheesh Nittur   +4 more
doaj   +2 more sources

Unmasking the chik sign: A case report on nasal hyperpigmentation as a diagnostic clue for chikungunya fever [PDF]

Malaysian Family Physician
Macular hyperpigmentation of the nasal region, often referred to as the ‘chik sign’, constitutes a distinctive physical manifestation associated with chikungunya fever.
Nurul Bariah Razali, Nurul Aliaa Mohammad Bokhari, Firdaus Ahmad   +2 more
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Decadal Change in Seroprevalence of Chikungunya Virus Infection in Pune City, India

Viruses, 2022
Chikungunya virus (CHIKV) is an arthropod-borne virus capable of causing large outbreaks. We aimed to determine the decadal change in the extent of chikungunya virus infection from 2009 to 2019. We implemented a prospective cross-sectional survey in Pune
Shilpa Jagatram Tomar, Kalichamy Alagarasu, Ashwini More, Manasi Nadkarni, Rupali Bachal, Minal Bote, Jayashri Patil, Vasanthy Venkatesh, Deepti Parashar, Babasaheb Vishwanath Tandale   +9 more
doaj   +1 more source

Oligonucleotide-Based Approaches to Inhibit Dengue Virus Replication

Molecules, 2021
Dengue fever is one of the most common viral infections affecting humans. It is an expanding public health problem, particularly in tropical and subtropical regions.
Kingshuk Panda, Kalichamy Alagarasu, Deepti Parashar   +2 more
doaj   +1 more source

Drug repurposing approach against chikungunya virus: an in vitro and in silico study

Frontiers in Cellular and Infection Microbiology, 2023
The chikungunya virus (CHIKV) is an alphavirus transmitted by Aedes mosquitoes. There are no licenced antivirals or vaccines for treatment or prevention. Drug repurposing approach has emerged as a novel concept to find alternative uses of therapeutics to
Bhagyashri Kasabe, Gunwant Ahire, Poonam Patil, Madhura Punekar, Kusuma Sai Davuluri, Mahadeo Kakade, Kalichamy Alagarasu, Deepti Parashar, Sarah Cherian   +8 more
doaj   +1 more source

A Transcriptomics-Based Bioinformatics Approach for Identification and In Vitro Screening of FDA-Approved Drugs for Repurposing against Dengue Virus-2

Viruses, 2022
The rising incidence of dengue virus (DENV) infections in the tropical and sub-tropical regions of the world emphasizes the need to identify effective therapeutic drugs against the disease.
Madhura Punekar, Bhagyashri Kasabe, Poonam Patil, Mahadeo B. Kakade, Deepti Parashar, Kalichamy Alagarasu, Sarah Cherian   +6 more
doaj   +1 more source

Targeted in vitro gene silencing of E2 and nsP1 genes of chikungunya virus by biocompatible zeolitic imidazolate framework

Frontiers in Bioengineering and Biotechnology, 2022
Chikungunya fever caused by the mosquito-transmitted chikungunya virus (CHIKV) is a major public health concern in tropical, sub-tropical and temperate climatic regions.
Rajarshee Tagore, Kalichamy Alagarasu, Poonam Patil, Suneela Pyreddy, Suneela Pyreddy, Shakil Ahmed Polash, Shakil Ahmed Polash, Mahadeo Kakade, Ravi Shukla, Ravi Shukla, Deepti Parashar   +10 more
doaj   +1 more source

In Vitro Antiviral Activity of Potential Medicinal Plant Extracts Against Dengue and Chikungunya Viruses

Frontiers in Cellular and Infection Microbiology, 2022
Dengue and chikungunya are two important mosquito-borne infections which are known to occur extensively in tropical and subtropical areas. Presently, there is no treatment for these viral diseases.
Kalichamy Alagarasu, Poonam Patil, Meenakshi Kaushik, Deepika Chowdhury, Rajesh K. Joshi, Harsha V. Hegde, Mahadeo B. Kakade, Sugeerappa Laxmanappa Hoti, Sarah Cherian, Deepti Parashar   +9 more
doaj   +1 more source

An Update on Current Antiviral Strategies to Combat Human Cytomegalovirus Infection

Viruses, 2023
Human cytomegalovirus (HCMV) remains an essential global concern due to its distinct life cycle, mutations and latency. As HCMV is a herpesvirus, it establishes a lifelong persistence in the host through a chronic state of infection.
Kingshuk Panda, Deepti Parashar, Rajlakshmi Viswanathan   +2 more
doaj   +1 more source

Understanding the Biology and Immune Pathogenesis of Chikungunya Virus Infection for Diagnostic and Vaccine Development

Viruses, 2022
Chikungunya virus, the causative agent of chikungunya fever, is generally characterized by the sudden onset of symptoms, including fever, rash, myalgia, and headache.
Mohamad S. Hakim, Abu T. Aman
doaj   +1 more source