Results 41 to 50 of about 49,500 (227)

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Chikungunya Virus

Clinics in Laboratory Medicine, 2017
For chikungunya virus (CHIKV), the long-term sequelae from infection are yet ill-defined. The prolonged debilitating arthralgia associated with CHIKV infection has tremendous potential for impacting the global economy and should be considered when evaluating the human burden of disease and the allocation of resources.
Vu, David M., Jungkind, Donald, Angelle Desiree LaBeaud   +2 more
openaire   +2 more sources

Repurposed drugs in combinations exert additive anti-chikungunya virus activity: an in-vitro study

Virology Journal
Chikungunya virus (CHIKV) infection causes chikungunya, a viral disease that currently has no specific antiviral treatment. Several repurposed drug candidates have been investigated for the treatment of the disease.
Kusuma Sai Davuluri, Rajnandini Ghanghav, Gunwant Ahire, Mahadeo Kakade, Sarah Cherian, Kalichamy Alagarasu, Deepti Parashar   +6 more
doaj   +1 more source

Hidden burden of chikungunya in North India; A prospective study in a tertiary care centre

Journal of Infection and Public Health, 2018
Background: Arboviral diseases, such as chikungunya, dengue and now zika represent a public health problem, especially in tropical countries. Epidemiology of chikungunya and dengue is well known, including its social and climatic factors associated, but ...
Anju Dinkar, Jitendra Singh, Pradyot Prakash, Arghya Das, Gopal Nath   +4 more
doaj   +1 more source

Design Space Assessment of Virus Inactivation in Plasma‐Derived Matrices Establishes a Single Detergent Alternative to TX‐100‐Containing Mixes

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The detergent Triton X‐100 (TX‐100) is a typical component of solvent/detergent (S/D) mixes applied for virus inactivation steps of biomanufacturing processes, yet environmentally unfavorable properties have led to restrictions on its use. Deviron 13‐S9 has recently been described as an eco‐friendly TX‐100 alternative, with powerful virus ...
Johanna Kindermann, Cecilie Klausen, Michael Karbiener, Thomas R. Kreil   +3 more
wiley   +1 more source

Revolutionizing Healthcare With Paper‐Based Nucleic Acid Testing

Exploration, EarlyView.
This work summarizes strategies to enhance paper‐based devices for nucleic acid testing. Key approaches include optimizing paper platforms, improving nucleic acid amplification, and refining labeling/signaling methods. These advancements aim to boost sensitivity, speed, and usability, making paper‐based diagnostics more effective for point‐of‐care ...
Hong Zhang, Yi Yang, Heng Li, Xiaolin Hu, Hui Xiao, Dou Wang, Sergio Benardini, Wei Gu, Yang Luo   +8 more
wiley   +1 more source

KEJADIAN PENYAKIT CHIKUNGUNYA DI WILAYAH KERJA PUSKESMAS KECAMATAN MAKASAR JAKARTA TIMUR

Jurnal Ilmiah Kesehatan, 2019
Chikungunya adalah suatu jenis penyakit menular yang disebabkan oleh virus Chikungunya (CHIK). Tujuan penelitian ini adalah “Diketahuinya faktor apa sajakah yang berhubungan  dengan kejadian Penyakit Chikungunya di wilayah kerja Puskesmas Kecamatan ...
Petrus Geroda Beda Ama
doaj   +1 more source

Seroprevalance of Dengue and Chikungunya Infection and their Seasonal Trends

Journal of Pure and Applied Microbiology, 2020
Dengue and Chikungunya are mosquito-borne arboviral infections with Aedes aegypti being the common vector for both.Manifestations of dengue fever closely resemble with the manifestations of Chikungunya.
C.Pooja, Mita D. Wadekar, S. Jayashree, J.V. Sathish   +3 more
doaj   +1 more source

Analysis of Gene Expression in Aedes aegypti Suggests Changes in Early Genetic Control of Mosquito Development

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
ABSTRACT Aedes aegypti, a critical vector for tropical diseases, poses significant challenges for studying its embryogenesis due to difficulties in removing its rigid chorion and achieving effective fixation for in situ hybridization. Here, we present novel methodologies for fixation, dechorionation, DAPI staining, and in situ hybridization, enabling ...
Renata Coutinho‐dos‐Santos, Danielle Santos, Lupis Ribeiro, Jonathan J. Mucherino‐Muñoz, Marcelle Uhl, Carlos Logullo, A. Mendonça‐Amarante, M. Fantappie, Rodrigo Nunes‐da‐Fonseca   +8 more
wiley   +1 more source

Seroprevalence of Chikungunya virus in blood donors from Northern and Southeastern Brazil

Hematology, Transfusion and Cell Therapy, 2018
Background: Chikungunya virus, an arbovirus that belongs to the Alphavirus genus of the Togaviridae family, causes a febrile illness accompanied by rash and arthralgia.
Svetoslav Nanev Slavov, Katia Kaori Otaguiri, Melina Lellis Bianquini, Hellen Tayana Oliveira Bitencourt, Marcia Cristina Munhoz Chagas, Domingos Sávio de Souza Guerreiro, Luiz Tadeu Moraes Figueiredo, Dimas Tadeu Covas, Simone Kashima   +8 more
doaj   +1 more source