Results 41 to 50 of about 84,186 (256)

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Repurposed drugs in combinations exert additive anti-chikungunya virus activity: an in-vitro study

Virology Journal
Chikungunya virus (CHIKV) infection causes chikungunya, a viral disease that currently has no specific antiviral treatment. Several repurposed drug candidates have been investigated for the treatment of the disease.
Kusuma Sai Davuluri, Rajnandini Ghanghav, Gunwant Ahire, Mahadeo Kakade, Sarah Cherian, Kalichamy Alagarasu, Deepti Parashar   +6 more
doaj   +1 more source

Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus [PDF]

, 2018
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Aquilimeba, Muriel, Kasvandik, Sergo, Lulla, Aleksei, Lulla, Valeria, McInerney, Gerald M., Merits, Andres, Morro, Ainhoa Moliner, Mutso, Margit, Saul, Sirle, Smedberg, Cecilia, Tarve, Liisi, Teppor, Mona, Thaa, Bastian, Varjak, Margus   +13 more
core   +3 more sources

The impacts of biological invasions

Biological Reviews, EarlyView.
ABSTRACT The Anthropocene is characterised by a continuous human‐mediated reshuffling of the distributions of species globally. Both intentional and unintentional introductions have resulted in numerous species being translocated beyond their native ranges, often leading to their establishment and subsequent spread – a process referred to as biological
Phillip J. Haubrock, Teun Everts, Neil Angelo S. Abreo, Jamie Bojko, Victor Deklerck, James W. E. Dickey, Ana Clara S. Franco, Emili García‐Berthou, Stelios Katsanevakis, Natalia I. Kirichenko, Stefano Mammola, Martin A. Nuñez, Ben Parker, Riccardo Scalera, Ismael Soto, Diederik Strubbe, Ali Serhan Tarkan, Lorenzo Vilizzi, Tim Adriaens, Paride Balzani, Dagmara Błońska, Elizabeta Briski, Rein Brys, Amy L. Burgess, James E. Byers, Carlos Cano‐Barbacil, Giuseppe Castaldelli, Jaimie T.A. Dick, Victoria Dominguez Almela, Romina D. Dimarco, Margarita Florencio, Antonín Kouba, Melina Kourantidou, Irmak Kurtul, Irene Martín‐Forés, Olivier Morissette, Julian D. Olden, Bruno E. Soares, Jakub Truszkowski, Hugo Verreycken, Marc Kenis, Ronaldo Sousa, J. Robert Britton   +42 more
wiley   +1 more source

Hidden burden of chikungunya in North India; A prospective study in a tertiary care centre

Journal of Infection and Public Health, 2018
Background: Arboviral diseases, such as chikungunya, dengue and now zika represent a public health problem, especially in tropical countries. Epidemiology of chikungunya and dengue is well known, including its social and climatic factors associated, but ...
Anju Dinkar, Jitendra Singh, Pradyot Prakash, Arghya Das, Gopal Nath   +4 more
doaj   +1 more source

Zika virus infection in the returning traveller: what every neurologist should know [PDF]

, 2018
Zika virus has been associated with a wide range of neurological complications. Neurologists in areas without current active transmission of the virus may be confronted with Zika-associated neurological disease, as a large number of returning travellers ...
Brito Ferreira, Maria Lucia, Jacobs, Bart C., Lant, Suzannah, Leonhard, Sonja Emily, Solomon, Tom, Wilder-Smith, Annelies, Willison, Hugh   +6 more
core   +6 more sources

Analysis of Gene Expression in Aedes aegypti Suggests Changes in Early Genetic Control of Mosquito Development

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
ABSTRACT Aedes aegypti, a critical vector for tropical diseases, poses significant challenges for studying its embryogenesis due to difficulties in removing its rigid chorion and achieving effective fixation for in situ hybridization. Here, we present novel methodologies for fixation, dechorionation, DAPI staining, and in situ hybridization, enabling ...
Renata Coutinho‐dos‐Santos, Danielle Santos, Lupis Ribeiro, Jonathan J. Mucherino‐Muñoz, Marcelle Uhl, Carlos Logullo, A. Mendonça‐Amarante, M. Fantappie, Rodrigo Nunes‐da‐Fonseca   +8 more
wiley   +1 more source

KEJADIAN PENYAKIT CHIKUNGUNYA DI WILAYAH KERJA PUSKESMAS KECAMATAN MAKASAR JAKARTA TIMUR

Jurnal Ilmiah Kesehatan, 2019
Chikungunya adalah suatu jenis penyakit menular yang disebabkan oleh virus Chikungunya (CHIK). Tujuan penelitian ini adalah “Diketahuinya faktor apa sajakah yang berhubungan  dengan kejadian Penyakit Chikungunya di wilayah kerja Puskesmas Kecamatan ...
Petrus Geroda Beda Ama
doaj   +1 more source

Seroprevalance of Dengue and Chikungunya Infection and their Seasonal Trends

Journal of Pure and Applied Microbiology, 2020
Dengue and Chikungunya are mosquito-borne arboviral infections with Aedes aegypti being the common vector for both.Manifestations of dengue fever closely resemble with the manifestations of Chikungunya.
C.Pooja, Mita D. Wadekar, S. Jayashree, J.V. Sathish   +3 more
doaj   +1 more source

Understanding the Wolbachia-mediated inhibition of arboviruses in mosquitoes: progress and challenges [PDF]

, 2014
Arthropod-borne viruses (arboviruses) pose a considerable threat to human and animal health, yet effective control measures have proven difficult to implement, and novel means of controlling their replication in arthropod vectors, such as mosquitoes, are
Dietrich, Isabelle, Kohl, Alain, Rainey, Stephanie M., Shah, Pranav   +3 more
core   +1 more source