Results 1 to 10 of about 10,808 (171)

Infectious Chikungunya Virus (CHIKV) with a Complete Capsid Deletion: a New Approach for a CHIKV Vaccine [PDF]

Journal of Virology, 2019
Currently, there is no licensed vaccine against CHIKV infection. An ideal CHIKV vaccine should generate an optimal balance between efficacy and safety. Live attenuated vaccines that can elicit strong immune responses often involve a trade-off of reduced safety. Here, a novel live attenuated vaccine candidate for CHIKV lacking the entire capsid gene, ΔC-
Cheng-Lin Deng, Qiu-Yan Zhang, Han-Qing Ye   +2 more
exaly   +5 more sources

Analysis of Humoral Immune Responses in Chikungunya Virus (CHIKV)-Infected Patients and Individuals Vaccinated With a Candidate CHIKV Vaccine [PDF]

Journal of Infectious Diseases, 2020
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes severe flu-like symptoms. The acute symptoms disappear after one week, but chronic arthralgia can persist for years.
Constanze Yue, Christine Von Rhein, Roland Tschismarov   +2 more
exaly   +6 more sources

Nonhuman Primate Models of Chikungunya Virus Infection and Disease (CHIKV NHP Model) [PDF]

Pathogens, 2015
Chikungunya virus (CHIKV) is a positive-sense RNA virus transmitted by Aedes mosquitoes. CHIKV is a reemerging Alphavirus that causes acute febrile illness and severe and debilitating polyarthralgia of the peripheral joints.
Rebecca Broeckel, Nicole N Haese, Ilhem Messaoudi   +2 more
exaly   +5 more sources

Genomic surveillance of the Chikungunya Virus (CHIKV) in Northeast Brazil after the first outbreak in 2014. [PDF]

Rev Soc Bras Med Trop, 2020
We performed an epidemiological surveillance of the Chikungunya (CHIKV) lineages in Bahia after the 2014 East/Central/South African (ECSA) genotype outbreak.Reverse-transcription polymerase chain reaction (RT-PCR), viral isolation, and phylogenetic analyses were conducted on serum samples from 605 patients with CHIKV-like symptoms during 2014-2018.Of ...
Rodrigues AM, Souza RRM, Fonseca LMDS, Rolo CA, Carvalho RH, Sardi SI, Campos GS.   +6 more
europepmc   +6 more sources

Chikungunya virus (CHIKV) seroprevalence in the South Pacific populations of the Cook Islands and Vanuatu with associated environmental and social factors. [PDF]

PLoS Negl Trop Dis, 2022
Background Arthropod-borne diseases pose a significant and increasing risk to global health. Given its rapid dissemination, causing large-scale outbreaks with severe human infections and economic loss, the Chikungunya virus (CHIKV) is one of the most important arboviruses worldwide. Despite its significance, the
Saretzki CEB, Dobler G, Iro E, May Y, Tou D, Lockington E, Ala M, Heussen N, Phiri BSJ, Küpper T.   +9 more
europepmc   +5 more sources

Evaluation of the Antiviral Potential of Halogenated Dihydrorugosaflavonoids and Molecular Modeling with nsP3 Protein of Chikungunya Virus (CHIKV). [PDF]

ACS Omega, 2019
Antiviral therapy is crucial for the circumvention of viral epidemics. The unavailability of a specific antiviral drug against the chikungunya virus (CHIKV) disease has created an alarming situation to identify or develop potent chemical molecules for remedial management of CHIKV.
Puranik NV, Rani R, Singh VA, Tomar S, Puntambekar HM, Srivastava P.   +5 more
europepmc   +5 more sources

A booster regime of liposome-delivered live-attenuated CHIKV vaccine RNA genome protects against chikungunya virus disease in mice

Vaccine, 2023
Mosquito-transmitted chikungunya virus (CHIKV) is the causal pathogen of CHIKV disease and is responsible for global epidemics of arthritic disease. CHIKV infection can lead to severe chronic and debilitating arthralgia, significantly impacting patient ...
Abeyratne, E, Yang, C, Liu, X, Shambhavi Rao, Ali Zaid, Helen Mostafavi, Zaid, A, Rao, S, Freitas, JR, Tharmarajah, K, Kothila Tharmarajah, Adam Taylor, Mehfuz Zaman, Xiang Liu, Mostafavi, H, Suresh Mahalingam, Zaman, M, Joseph R. Freitas, Eranga Abeyratne, Mahalingam, S, Chenying Yang, Taylor, A   +21 more
exaly   +2 more sources

Optimum level of NEDD4 and its interaction with nsP3 are crucial to facilitate efficient Chikungunya virus (CHIKV) infection. [PDF]

J Gen Virol
Chikungunya is a febrile infection caused by the Chikungunya virus (CHIKV), an alphavirus which has emerged as a serious public health problem globally. Despite extensive research, our understanding of different host factors facilitating effective CHIKV infection is not clear yet. NEDD4, a member of the E3 ubiquitin ligase, is one such protein.
Verma S, Chatterjee S, Keshry SS, Dhal AK, Bhowmick B, Newar J, Chattopadhyay S, Ghatak A.   +7 more
europepmc   +3 more sources

Extensive evolution analysis of the global chikungunya virus strains revealed the origination of CHIKV epidemics in Pakistan in 2016 [PDF]

Virologica Sinica, 2017
Chikungunya virus (CHIKV) is a mosquito-borne virus that causes epidemics widely in the world especially in the tropical and subtropical regions. Phylogenetic analysis has found that the CHIKV lineages were associated with the spatial and temporal distributions, which were related to the virus adaption to the major mosquito species and their ...
Zhengyuan Su, Zhaojun Fan, Bo Zhang
exaly   +3 more sources

A recombinant CHIKV-NLuc virus identifies chondrocytes as target of Chikungunya virus in a immunocompetent mouse model

International audienceFirst isolated in 1953 in Tanzania, the arthritogenic Chikungunya virus (CHIKV) re-emerged globally in 2005, leading to widespread outbreaks.
Desprès, Philippe, Belarbi, Essia, Gessain, Antoine, Jeannin, Patricia, Hardy, David, Choumet, Valérie, Kümmerer, Beate, Roques, Pierre, Ceccaldi, Pierre-Emmanuel, Legros, Vincent   +9 more
core   +2 more sources