Infectious Chikungunya Virus (CHIKV) with a Complete Capsid Deletion: a New Approach for a CHIKV Vaccine. [PDF]
J Virol, 2019 Currently, there is no licensed vaccine against CHIKV infection. An ideal CHIKV vaccine should generate an optimal balance between efficacy and safety. Live attenuated vaccines that can elicit strong immune responses often involve a trade-off of reduced safety. Here, a novel live attenuated vaccine candidate for CHIKV lacking the entire capsid gene, ΔC-
Zhang YN +7 more
europepmc +6 more sources
Genomic surveillance of the Chikungunya Virus (CHIKV) in Northeast Brazil after the first outbreak in 2014. [PDF]
Rev Soc Bras Med Trop, 2020 We performed an epidemiological surveillance of the Chikungunya (CHIKV) lineages in Bahia after the 2014 East/Central/South African (ECSA) genotype outbreak.Reverse-transcription polymerase chain reaction (RT-PCR), viral isolation, and phylogenetic analyses were conducted on serum samples from 605 patients with CHIKV-like symptoms during 2014-2018.Of ...
Rodrigues AM +6 more
europepmc +5 more sources
Chikungunya virus (CHIKV) inhibitors from natural sources: a medicinal chemistry perspective [PDF]
Journal of Natural Medicines, 2015 Abstract Chikungunya virus (CHIKV) is one of the re-emerging “neglected” tropical diseases whose recent outbreak affected not only Africa and South-East Asia but also several parts of America and Europe. To date, despite its serious nature, no antivirals or vaccines were developed in order to counter this resurgent infectious ...
Bhakat, Soumendranath +1 more
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Evaluation of the Antiviral Potential of Halogenated Dihydrorugosaflavonoids and Molecular Modeling with nsP3 Protein of Chikungunya Virus (CHIKV). [PDF]
ACS Omega, 2019 Antiviral therapy is crucial for the circumvention of viral epidemics. The unavailability of a specific antiviral drug against the chikungunya virus (CHIKV) disease has created an alarming situation to identify or develop potent chemical molecules for remedial management of CHIKV.
Puranik NV +5 more
europepmc +5 more sources
Optimum level of NEDD4 and its interaction with nsP3 are crucial to facilitate efficient Chikungunya virus (CHIKV) infection. [PDF]
J Gen VirolChikungunya is a febrile infection caused by the Chikungunya virus (CHIKV), an alphavirus which has emerged as a serious public health problem globally. Despite extensive research, our understanding of different host factors facilitating effective CHIKV infection is not clear yet. NEDD4, a member of the E3 ubiquitin ligase, is one such protein.
Verma S +7 more
europepmc +2 more sources
Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation [PDF]
Virology Journal, 2013 10.1186/1743-422X-10-36Virology ...
Ng, M.-L. +2 more
core +5 more sources
Proteomics Profiling of Chikungunya-Infected Aedes albopictus C6/36 Cells Reveal Important Mosquito Cell Factors in Virus Replication [PDF]
, 2015 10.1371/journal.pntd.0003544PLoS Neglected Tropical ...
Chu, Jang Hann, Lee, Regina Ching Hua
core +28 more sources
Continuous Circulation of Chikungunya Virus during COVID-19 Pandemic in Jambi, Sumatra, Indonesia
Tropical Medicine and Infectious Disease, 2022 Chikungunya fever is a self-limiting viral illness that is caused by the chikungunya virus (CHIKV). CHIKV is found in multiple provinces of Indonesia, with clustered local outbreaks.
Marsha Sinditia Santoso +8 more
doaj +1 more source
Frontiers in Microbiology, 2023 Chikungunya fever (CHIF), a vector-borne disease transmitted mainly by Aedes albopictus and Aedes aegypti, is caused by Chikungunya virus (CHIKV) infection. To date, it is estimated that 39% of the world’s population is at risk of infection for living in
Jia Li +8 more
doaj +1 more source
The research progress of Chikungunya fever
Frontiers in Public Health, 2023 Chikungunya fever, an acute infectious disease caused by Chikungunya virus (CHIKV), is transmitted by Aedes aegypti mosquitoes, with fever, rash, and joint pain as the main features.
Li Cai +8 more
doaj +1 more source