Mathematical analysis and control of chikungunya (CHIKV) virus by SEIR model
Chikungunya is a re-emerging arboviral disease in Asia and Africa infected by Aedes mosquitoes which had posed a global threat in several countries. Vector borne diseases are the primary cause of death in most of the world countries, hence it becomes pertinent to control these vector borne diseases.
Seema Singla, Madhuchanda Rakshit
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Attenuation and Stability of CHIKV-NoLS, a Live-Attenuated Chikungunya Virus Vaccine Candidate [PDF]
Our previous investigation of the nucleolar localisation sequence (NoLS) of chikungunya virus (CHIKV) capsid protein demonstrated the role of capsid in CHIKV virulence. Mutating the NoLS of capsid in CHIKV led to the development of a unique live-attenuated CHIKV vaccine candidate, termed CHIKV-NoLS.
Eranga Abeyratne +4 more
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Treatment of Chikungunya Virus (CHIKV) Using Targeted Immunotherapy
Chikungunya virus (CHIKV) is the most common mosquito-borne Alphavirus infecting humans worldwide. Up to date, there are no antiviral treatments or vaccines approved to treat or prevent CHIKV for which treatments remain symptomatic based on clinical manifestations.
Fleury Augustin Nsole Biteghe +5 more
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Functional processing and secretion of Chikungunya virus E1 and E2 glycoproteins in insect cells [PDF]
Background: Chikungunya virus (CHIKV) is a mosquito-borne, arthrogenic Alphavirus that causes large epidemics in Africa, South-East Asia and India. Recently, CHIKV has been transmitted to humans in Southern Europe by invading and now established Asian ...
Geertsema, C (Corinne) +44 more
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Chikungunya virus (CHIKV) inhibitors from natural sources: a medicinal chemistry perspective [PDF]
Abstract Chikungunya virus (CHIKV) is one of the re-emerging “neglected” tropical diseases whose recent outbreak affected not only Africa and South-East Asia but also several parts of America and Europe. To date, despite its serious nature, no antivirals or vaccines were developed in order to counter this resurgent infectious ...
Bhakat, Soumendranath +1 more
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Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M. +34 more
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Challenges in Surveillance for Chikungunya Virus (CHIKV) Infection
We describe challenges and lessons learned using biosurveillance methods for identifying Chikungunya (CHIKV) infections. Surveillance was performed using VA ESSENCE, electronic laboratory data and facility reports. As of Aug. 14, 2014, 21 confirmed/probable cases were identified at 10 hospitals.
Lucero-Obusan, Cynthia A. +3 more
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ViennaRNA/CHIKV: CHIKVnext v5.1
CHIKVnext is an interactive resource to study the evolution and global spread of Chikungunya virus (CHIKV), built on the Nextstrain platform.
Michael T. Wolfinger +2 more
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Analysis and characterization of mouse monoclonal antibodies reactive to Chikungunya virus (CHIKV) [PDF]
occurring in 1984). However, plague has made an astonishing comeback in the last decade. Methods: n/a. Results: After a silence of 50 years, an outbreak of bubonic plague suddenly occurred close to Oran in Algeria, in June 2003. Eighteen bubonic cases were identified, and Yersinia pestis was isolated from 6 patients.
Rossini, G. +5 more
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Chikungunya virus (CHIKV) infection: Analytical performance of real-time NASBA assay [PDF]
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G. Rossini +5 more
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