Results 31 to 40 of about 36,220 (197)

RNAi-Induced Gene Silencing against Chikungunya and COVID-19: What Have We Learned So Far, and What Is the Way Forward?

Viruses
RNA interference (RNAi) is a process in which small RNA molecules (such as small interfering RNAs or siRNAs) bind to specific messenger RNAs (mRNAs), leading to its degradation and inhibition of protein synthesis.
Kingshuk Panda, Kalichamy Alagarasu, Rajarshee Tagore, Mandar Paingankar, Satyendra Kumar, Manish Kumar Jeengar, Sarah Cherian, Deepti Parashar   +7 more
doaj   +1 more source

Chikungunya Virus

Clinics in Laboratory Medicine, 2017
For chikungunya virus (CHIKV), the long-term sequelae from infection are yet ill-defined. The prolonged debilitating arthralgia associated with CHIKV infection has tremendous potential for impacting the global economy and should be considered when evaluating the human burden of disease and the allocation of resources.
Vu, David M., Jungkind, Donald, Angelle Desiree LaBeaud   +2 more
openaire   +2 more sources

Revolutionizing Healthcare With Paper‐Based Nucleic Acid Testing

Exploration, EarlyView.
This work summarizes strategies to enhance paper‐based devices for nucleic acid testing. Key approaches include optimizing paper platforms, improving nucleic acid amplification, and refining labeling/signaling methods. These advancements aim to boost sensitivity, speed, and usability, making paper‐based diagnostics more effective for point‐of‐care ...
Hong Zhang, Yi Yang, Heng Li, Xiaolin Hu, Hui Xiao, Dou Wang, Sergio Benardini, Wei Gu, Yang Luo   +8 more
wiley   +1 more source

Repurposed drugs in combinations exert additive anti-chikungunya virus activity: an in-vitro study

Virology Journal
Chikungunya virus (CHIKV) infection causes chikungunya, a viral disease that currently has no specific antiviral treatment. Several repurposed drug candidates have been investigated for the treatment of the disease.
Kusuma Sai Davuluri, Rajnandini Ghanghav, Gunwant Ahire, Mahadeo Kakade, Sarah Cherian, Kalichamy Alagarasu, Deepti Parashar   +6 more
doaj   +1 more source

Analysis of the dynamics of a vector-borne infection with the effect of imperfect vaccination from a fractional perspective

Scientific Reports, 2023
The burden of vector-borne infections is significant, particularly in low- and middle-income countries where vector populations are high and healthcare infrastructure may be inadequate.
Tao-Qian Tang, Rashid Jan, Adil Khurshaid, Zahir Shah, Narcisa Vrinceanu, Mihaela Racheriu   +5 more
doaj   +1 more source

Economic Impact of Dengue Virus in Mexico Over One Decade: A Systematic Literature Review (2010–2020)

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Background Dengue is a major mosquito‐borne viral disease worldwide, imposing significant healthcare burden on governments in countries where it is endemic, such as Mexico. This systematic review focused on studies reporting the cost of dengue in Mexico during 2010–2020.
Gilberto Sánchez‐González, Luz del C. Hernández‐Hernández, Elaine Gallagher   +2 more
wiley   +1 more source

Hidden burden of chikungunya in North India; A prospective study in a tertiary care centre

Journal of Infection and Public Health, 2018
Background: Arboviral diseases, such as chikungunya, dengue and now zika represent a public health problem, especially in tropical countries. Epidemiology of chikungunya and dengue is well known, including its social and climatic factors associated, but ...
Anju Dinkar, Jitendra Singh, Pradyot Prakash, Arghya Das, Gopal Nath   +4 more
doaj   +1 more source

Increased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection

Pathogens, 2022
Chikungunya virus (CHIKV) infection causes intense cytokine/chemokine inflammatory responses and debilitating joint pain. Indoleamine2,3–dioxygenase 1 (IDO-1) is an enzyme that initiates the tryptophan degradation that is important in initial host innate
Thiara Manuele Alves de Souza, Caroline Fernandes-Santos, Jéssica Araújo da Paixão de Oliveira, Larissa Cristina Teixeira Tomé, Victor Edgar Fiestas-Solórzano, Priscila Conrado Guerra Nunes, Gabriel Macedo Costa Guimaraes, Juan Camilo Sánchez-Arcila, Iury Amâncio Paiva, Luís Jose de Souza, Paulo Vieira Damasco, Válber da Silva Frutuoso, Manoela Heringer, Luzia Maria de Oliveira-Pinto, Roberta Olmo Pinheiro, Flavia Barreto dos Santos, Elzinandes Leal de Azeredo   +16 more
doaj   +1 more source

A multiplex interactome of Ebola virus proteins reveals TM9SF2 as a cell‐surface attachment factor that promotes viral entry

iMetaOmics, EarlyView.
This study generates a comprehensive Ebola virus (EBOV)‐human protein–protein interactome, comprising 1728 core high‐confidence interactions. Further interactome analysis revealed the potential association of EBOV glycoprotein (GP) with the host factor TM9SF2. Subsequent mechanistic investigations confirmed that TM9SF2 functions as an attachment factor
Limin Shang, Shouwen Du, Yuchen Liu, Letian Li, Xi Wu, Yanzhi Yuan, Chaozhi Jin, Qingkun Mi, Yuhang Wang, Xiaoshuang Shi, Jiamin Wang, Guoqing Zhang, Yidan Ma, Weijin Huang, Jigang Wang, Jian Wang, Chang Li   +16 more
wiley   +1 more source

Seroprevalence of Chikungunya virus in blood donors from Northern and Southeastern Brazil

Hematology, Transfusion and Cell Therapy, 2018
Background: Chikungunya virus, an arbovirus that belongs to the Alphavirus genus of the Togaviridae family, causes a febrile illness accompanied by rash and arthralgia.
Svetoslav Nanev Slavov, Katia Kaori Otaguiri, Melina Lellis Bianquini, Hellen Tayana Oliveira Bitencourt, Marcia Cristina Munhoz Chagas, Domingos Sávio de Souza Guerreiro, Luiz Tadeu Moraes Figueiredo, Dimas Tadeu Covas, Simone Kashima   +8 more
doaj   +1 more source