Results 41 to 50 of about 45,477 (213)

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source

Epidemiological serosurvey of chikungunya fever post outbreak at Tanjung Sepat, Malaysia

Journal of Infection in Developing Countries, 2023
Introduction: Chikungunya fever is a mosquito-borne viral disease that usually presents with prominent arthralgia. An outbreak of chikungunya fever was reported in Tanjung Sepat, Malaysia in 2019.
Chee-Sieng Khor, Boon-Teong Teoh, Sing-Sin Sam, Hooi-Yuen Khoo, Noor-Syahida Azizan, AsmaAnati CheMatSeri, Kim-Ling Chin, Zur-Raiha Hamim, Noor-Adila Mohamed-Romai-Noor, Che-Norainon Yaacob, Juraina Abd-Jamil, Hai-Yen Lee, Yih-Harng Soh, Sazaly AbuBakar   +13 more
doaj   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Exploring the Role of Pattern Recognition Receptors as Immunostimulatory Molecules

Immunity, Inflammation and Disease
Background Pattern recognition receptors (PRRs) are the receptors of the innate immune system that play a vital role in initiating innate immune response.
Meenal Sharma, Priyanka Wagh, Tanvi Shinde, Diptee Trimbake, Anuradha S. Tripathy   +4 more
doaj   +1 more source

Histopathological and immunological characteristics of placentas infected with chikungunya virus

Frontiers in Microbiology, 2022
Although vertical transmission of CHIKV has been reported, little is known about the role of placenta in the transmission of this virus and the effects of infection on the maternal-fetal interface.
Natália Salomão, Natália Salomão, Kíssila Rabelo, Elyzabeth Avvad-Portari, Carlos Basílio-de-Oliveira, Rodrigo Basílio-de-Oliveira, Fátima Ferreira, Luiz Ferreira, Thiara Manuele de Souza, Priscila Nunes, Monique Lima, Anna Paula Sales, Regina Fernandes, Regina Fernandes, Luiz José de Souza, Luiz José de Souza, Laura Dias, Patrícia Brasil, Flavia dos Santos, Marciano Paes   +19 more
doaj   +1 more source

Estimating Velocities of Infectious Disease Spread Through Spatio‐Temporal Log‐Gaussian Cox Point Processes

International Statistical Review, EarlyView.
Summary Understanding the spread of infectious diseases such as COVID‐19 is crucial for informed decision‐making and resource allocation. A critical component of disease behaviour is the velocity with which disease spreads, defined as the rate of change between time and space.
Fernando Rodriguez Avellaneda, Jorge Mateu, Paula Moraga   +2 more
wiley   +1 more source

The Ecological Factors Associated With the Survival, Establishment, and Movement of Aedes aegypti and Ae. albopictus: A Scoping Review

Journal of Applied Entomology, EarlyView.
ABSTRACT Aedes aegypti and Ae. albopictus are mosquito species of public health significance and collectively responsible for the transmission of several arboviruses. Ongoing climatic changes are anticipated to have impacts on their survival, establishment, and movement.
Keana Shahin, Sydney DeWinter, Olaf Berke, Ilaria Dorigatti, Victoria Ng, Katie M. Clow   +5 more
wiley   +1 more source

HUBUNGAN FAKTOR PERILAKU DAN LINGKUNGAN DENGAN KEJADIAN LUAR BIASA SUSPEK CHIKUNGUNYA DI DESA JASRI, WILAYAH KERJA PUSKESMAS KARANGASEM I, KABUPATEN KARANGASEM TAHUN 2017

Saintika Medika, 2018
Latarbelakang. Chikungunya merupakan salahsatu penyakit infeksi dengan gejala demam, nyeri sendi, dan ruam yang disebabkan oleh virus chikungunya (CHIKV) dan ditularkan melalui gigitan nyamuk.
David Budi Lukito, Soraya Juventia Primadanti, Rania Ayu Permata, wayan citra wulan   +3 more
doaj   +1 more source

Knowledge and awareness of chikungunya and public health assessment of Dhaka and Brahmanbaria, Bangladesh [PDF]

, 2021
Rajia Sultana Nijhu, Ambia Khatun, Mohammad Abdul Mannan   +2 more
openalex   +1 more source

Preimaginal development of Aedes aegypti L. (Diptera: Culicidae) in brackish water gives rise to adult mosquitoes with thicker cuticles and greater insecticide resistance

Medical and Veterinary Entomology, EarlyView.
The principal arboviral vector Aedes aegypti can develop in coastal brackish water field habitats (0.5–15 g/L salt) with larvae possessing thicker cuticles and greater resistance to the larvicide Temephos. Females emerging from brackish water‐developing preimaginal stages are now shown to have thicker and remodelled leg and abdominal cuticles and ...
Kokila Sivabalakrishnan, Andrew Hemphill, S. H. P. Parakrama Karunaratne, Arunasalam Naguleswaran, Isabel Roditi, Sinnathamby N. Surendran, Ranjan Ramasamy   +6 more
wiley   +1 more source