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Chikungunya virus and prospects for a vaccine [PDF]

Expert Review of Vaccines, 2012
In 2004, chikungunya virus (CHIKV) re-emerged from East Africa to cause devastating epidemics of debilitating and often chronic arthralgia that have affected millions of people in the Indian Ocean Basin and Asia. More limited epidemics initiated by travelers subsequently occurred in Italy and France, as well as human cases exported to most regions of ...
Scott C, Weaver, Jorge E, Osorio, Jill A, Livengood, Rubing, Chen, Dan T, Stinchcomb   +4 more
openaire   +2 more sources

Diagnóstico diferencial de dengue y chikungunya en pacientes pediátricos

Biomédica: revista del Instituto Nacional de Salud, 2016
Introducción. Las infecciones por el virus del dengue y del chikungunya presentan síntomas clínicos similares, lo cual dificulta el diagnóstico clínico. Además, son transmitidas por los mismos vectores, por lo que en una región puede haber circulación e ...
Eliana Patricia Calvo, Carolina Coronel-Ruiz, Syrley Velazco, Myriam Velandia-Romero, Jaime E. Castellanos   +4 more
doaj   +1 more source

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source

Healthcare workers knowledge and diagnostic practices: a need for dengue and chikungunya training in Moshi Municipality, Kilimanjaro Tanzania

BMC Research Notes, 2019
Objective Dengue and chikungunya virus diseases are becoming an increasingly important global health threats and are continuously expanding their geographical range.
Samwel Saringe, Debora C. Kajeguka, Dickson D. Kagirwa, Maseke R. Mgabo, Basiliana Emidi   +4 more
doaj   +1 more source

Post–Chikungunya Virus Infection Musculoskeletal Disorders: Syndromic Sequelae after an Outbreak

Tropical Medicine and Infectious Disease, 2021
The Chikungunya virus is a re-emerging mosquito-borne alphavirus. Outbreaks are unpredictable and explosive in nature. Fever, arthralgia, and rash are common symptoms during the acute phase.
Hisham A. Imad, Wasin Matsee, Sajikapon Kludkleeb, Punyisa Asawapaithulsert, Juthamas Phadungsombat, Emi E. Nakayama, Keita Suzuki, Pornsawan Leaungwutiwong, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, Tatsuo Shioda   +10 more
doaj   +1 more source

Exploring the Development of Vaccine Platforms, With a Particular Focus on the COVID‐19 Pandemic

Acta Paediatrica, EarlyView.
ABSTRACT Vaccines have been a cornerstone of human health for more than 200 years and one of the most important tools to reduce childhood deaths caused by pathogens. The concept of vaccines is basically to take something safe, make it immunogenic and induce an immune response in the host that will protect it against something dangerous. Live attenuated
Matti Sällberg
wiley   +1 more source

A vaccinia-based single vector construct multi-pathogen vaccine protects against both Zika and chikungunya viruses

Nature Communications, 2018
Zika and chikungunya virus are co-circulating in many regions and currently there is no approved vaccine for either virus. Here, the authors engineer one vaccinia virus based vaccine for both, Zika and chikungunya, and show protection from infection and ...
Natalie A. Prow, Liang Liu, Eri Nakayama, Tamara H. Cooper, Kexin Yan, Preethi Eldi, Jessamine E. Hazlewood, Bing Tang, Thuy T. Le, Yin Xiang Setoh, Alexander A Khromykh, Jody Hobson-Peters, Kerrilyn R. Diener, Paul M. Howley, John D. Hayball, Andreas Suhrbier   +15 more
doaj   +1 more source

Chikungunya myeloradiculopathy: A rare complication

Journal of Global Infectious Diseases, 2012
Chikungunya, an alpha virus belonging to the family of Togaviridae is transmitted to humans by the bite of Aedes aegypti mosquito and presents with fever, headache, rash, and severe arthralgia.
Mohana Krishnan, Rahul, Krishnamoorthy
doaj   +1 more source

Preimaginal development of Aedes aegypti L. (Diptera: Culicidae) in brackish water gives rise to adult mosquitoes with thicker cuticles and greater insecticide resistance

Medical and Veterinary Entomology, EarlyView.
The principal arboviral vector Aedes aegypti can develop in coastal brackish water field habitats (0.5–15 g/L salt) with larvae possessing thicker cuticles and greater resistance to the larvicide Temephos. Females emerging from brackish water‐developing preimaginal stages are now shown to have thicker and remodelled leg and abdominal cuticles and ...
Kokila Sivabalakrishnan, Andrew Hemphill, S. H. P. Parakrama Karunaratne, Arunasalam Naguleswaran, Isabel Roditi, Sinnathamby N. Surendran, Ranjan Ramasamy   +6 more
wiley   +1 more source

SEROPREVALENCE OF MOSQUITO-BORN AND TICK-BORN MICROORGANISMS IN HUMAN POPULATION OF SOUTH BACKA DISTRICT

Archives of Veterinary Medicine, 2016
Chikungunya virus is an Arbo virus belonging to the family Togaviridae. In urban areas, antropophilic Aedes aegypti and Aedes albopictus mosquitoes are vectors for virus transmission to human population.
Ivana Hrnjaković Cvjetković, Tamaš Petrović, Dušan Petrić, Dejan Cvjetković, Gordana Kovačević, Jelena Radovanov, Aleksandra Jovanović Galović, Aleksandra Pat, Nataša Nikolić, Sandra Stefan Mikić, Vesna Milošević   +10 more
doaj   +1 more source