Results 111 to 120 of about 19,855 (219)

The Approved Live-Attenuated Chikungunya Virus Vaccine (IXCHIQ®) Elicits Cross-Neutralizing Antibody Breadth Extending to Multiple Arthritogenic Alphaviruses Similar to the Antibody Breadth Following Natural Infection

Vaccines
The first vaccine against chikungunya virus (CHIKV) was recently licensed in the U.S., Europe, and Canada (brand IXCHIQ®, referred to as VLA1553). Other pathogenic alphaviruses co-circulate with CHIKV and major questions remain regarding the potential of
W. Weber, Zachary J. Streblow, C. Kreklywich, Michael C. Denton, Gauthami Sulgey, Magdalene M Streblow, Dorca Marcano, Paola N Flores, Rachel M. Rodriguez-Santiago, Luisa I. Alvarado, Vanessa Rivera-Amill, William B. Messer, R. Hochreiter, Karin Kosulin, Katrin L. Dubischar, Vera Buerger, D. Streblow   +16 more
semanticscholar   +1 more source

How do I interpret transfusion transmissible infectious disease testing in a low‐risk donor population?

Transfusion, Volume 65, Issue 12, Page 2236-2249, December 2025.
Abstract Background Blood donors represent a unique population. Pre‐donation screening questions, donor self‐deferral, and temporary deferral and re‐testing of repeat reactive donors result in lower prevalence of infectious disease compared to the general population.
Carmen L. Charlton, Mark Bigham, Sheila F. O'Brien, Steven J. Drews   +3 more
wiley   +1 more source

Structure‐Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus‐2 Nsp3 Macrodomain

ChemBioChem, Volume 26, Issue 23, November 27, 2025.
Structure‐guided design of a sulfamoyl‐modified analog of GS‐441524 yielded a selective, high‐affinity inhibitor of the SARS‐CoV‐2 macrodomain Nsp3b. The compound occupies the phosphate‐binding pocket, forming a stabilizing hydrogen‐bond network that enhances binding affinity (K_D = 0.86 μM).
Robin Krishnathas, Konstantin S. Mineev, Nikolaos K. Fourkiotis, Franck Touret, Christos Sideras‐Bisdekis, Aikaterini C. Tsika, Santosh Lakshmi Gande, Verena Linhard, Sridhar Sreeramulu, Frank Lennartz, Manfred S. Weiss, Bruno Coutard, Georgios A. Spyroulias, Harald Schwalbe   +13 more
wiley   +1 more source

Progress in prevention and treatment of Chikungunya fever

Guangxi Yike Daxue xuebao
Chikungunya fever (CHIKF) is an infectious disease caused by Chikungunya virus (CHIKV) infection. The CHIKV is mainly transmitted through the bites of Aedes mosquitoes.
Zukang GONG, Bin XU, Wenzhen LIN
doaj   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Reemergence of Chikungunya Virus in Cambodia

Emerging Infectious Diseases, 2012
Chikungunya virus (CHIKV), probably Asian genotype, was first detected in Cambodia in 1961. Despite no evidence of acute or recent CHIKV infections since 2000, real-time reverse transcription PCR of serum collected in 2011 detected CHIKV, East Central ...
Veasna Duong, Anne-Claire Andries, Chantha Ngan, Touch Sok, Beat Richner, Nima Asgari-Jirhandeh, Steve Bjorge, Rekol Huy, Sovann Ly, Denis Laurent, Bunheng Hok, Maria Concepcion Roces, Sivuth Ong, Meng Chuor Char, Vincent Deubel, Arnaud Tarantola, Philippe Buchy   +16 more
doaj   +1 more source

An All‐in‐One Metabarcoding Approach to Mosquito and Arbovirus Xenosurveillance

Molecular Ecology Resources, Volume 25, Issue 8, November 2025.
ABSTRACT Next‐generation sequencing (NGS) has the potential to transform mosquito‐borne disease surveillance but remains under‐utilised. This study introduces a comprehensive multi‐loci metabarcoding‐based MX (molecular xenomonitoring) approach to mosquito and arbovirus surveillance, enabling parallel identification of mosquito vectors, circulating ...
Brian J. Johnson, Melissa C. Graham, Elina Panahi, Carla Julia S. P. Vieira, Nisa Suraj Nath, Paul Mason, Jamie Gleadhill, Darran Thomas, Michael B. Onn, Martin A. Shivas, Damien Shearman, Jonathan M. Darbro, Gregor J. Devine   +12 more
wiley   +1 more source

Molecular and Clinical Characterization of Chikungunya Virus Infections in Southeast Mexico

Viruses, 2018
Chikungunya fever is an arthropod-borne infection caused by Chikungunya virus (CHIKV). Even though clinical features of Chikungunya fever in the Mexican population have been described before, there is no detailed information. The aim of this study was to
Kame A. Galán-Huerta, Erik Martínez-Landeros, Juan L. Delgado-Gallegos, Sandra Caballero-Sosa, Iliana R. Malo-García, Ildefonso Fernández-Salas, Javier Ramos-Jiménez, Ana M. Rivas-Estilla   +7 more
doaj   +1 more source

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil, Josh J. Friesen, Nuthan V. Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y. S. Kong, Andrew J. Varley, Shigeki J. Miyake‐Stoner, Parinaz Aliahmad, Nathaniel S. Wang, Andrew J. Geall, Anna K. Blakney   +12 more
wiley   +1 more source

TIMP‐2 as a Potential Indicator of Persistent Arthralgia in Chikungunya: Evidence From a Brazilian Cohort Study

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
ABSTRACT Chikungunya virus (CHIKV) infection can trigger a sustained inflammatory response, often leading to chronic musculoskeletal pain. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) may contribute to the persistence of arthralgia through their involvement in joint tissue remodeling and degradation. This study aimed to evaluate
Ana Clara Santos Costa, Anderson Felix dos Santos, Gabriela Cavalcanti Lima Albuquerque, Michelle Melgarejo da Rosa, Jamile Taniele‐Silva, Angela Luzia Branco Pinto Duarte, Maira Galdino da Rocha Pitta, André Machado de Siqueira, Amanda Pinheiro de Barros Albuquerque, Moacyr Jesus Barreto de Melo Rego   +9 more
wiley   +1 more source