Results 121 to 130 of about 1,377,517 (218)

Genomic epidemiology of Chikungunya virus in Colombia reveals genetic variability of strains and multiple geographic introductions in outbreak, 2014

, 2019
Chikungunya virus (CHIKV) is considered a public health problem due to its rapid spread and high morbidity. This study aimed to determine the genetic diversity and phylogenetic relationships of CHIKVs in Colombia.
Puerta González, Andrés, Peláez Carvajal, Dioselina, Mattar Velilla, Ameth Salim, Hoyos Lopez, Richard Onalbi, Pinzón, Hernando, Muskus, Carlos, Villero Wolf, Yeneiris Karina, Arrieta Bernate, Germán Javier   +7 more
core   +1 more source

Transcriptome analysis of human macrophages upon chikungunya virus (CHIKV) infection reveals regulation of distinct signaling and metabolic pathways during the early and late stages of infection. [PDF]

Heliyon, 2023
Srivastava P, Chaudhary S, Malhotra S, Varma B, Sunil S.   +4 more
europepmc   +1 more source

Patients with chikungunya virus test results identified—Veterans Health Administration, 2014.

, 2016
One excluded patient with an apparent false-positive CHIKV IgM/IgG result 4 days after symptom onset had no travel to an area with CHIKV transmission; repeat testing was negative. CHIKV, chikungunya virus; reverse transcriptase PCR (RT-PCR).
Mark Holodniy (134544), Patricia L. Schirmer (389602), Mark A. Winters (315377), Tara Perti (2656849), Cynthia A. Lucero-Obusan (389603)   +4 more
core   +1 more source

Therapeutics and Vaccines Against Chikungunya Virus

, 2015
Erratum in Correction to: Vector Borne Zoonotic Dis 2015;15(4):250-257 DOI: 10.1089/vbz.2014.1681. [Vector Borne Zoonotic Dis. 2015]International audienceCurrently, there are no licensed vaccines or therapies available against chikungunya virus (CHIKV)
Ann Powers, Powers, A, Esteban, M, Esteban, Mariano, Mariano Esteban, Hallengärd, David, Couderc, Thérèse, Ng, Lisa F.P., Ng, LFP, Peter Liljeström, Merits, Andres, Roques, P, Liljeström, Peter, Andres Merits, Courderc, T, Lecuit, Marc, Therese Couderc, Liljestrom, P, Pierre Roques, Merits, A, Powers, Ann, Roques, Pierre, Marc Lecuit, Ahola, Tero, Lisa F.P. Ng, Lecuit, M, David Hallengärd, Tero Ahola, Hallengard, D, Ahola, T   +29 more
core   +1 more source

IgM-specific linear epitopes on the E2 protein for serodiagnosis of Chikungunya

Virus Research
Chikungunya virus (CHIKV) and Dengue virus (DENV) are vector-borne diseases transmitted by Aedes aegypti and Aedes albopictus that pose a significant threat to global public health. Cases of acute Chikungunya fever often present similar clinical symptoms
Qianlin Li, Jun Dai, Yongxia Shi, Qiang Deng, Conghui Liao, Jicheng Huang, Jiahai Lu   +6 more
doaj   +1 more source

A chikungunya virus-like particle vaccine reduces chikungunya disease in cynomolgus macaques and protection is mediated by antibody transferred from vaccinated humans

npj Vaccines
Chikungunya virus (CHIKV) causes periodic outbreaks and is endemic in more than 110 countries. VIMKUNYA, a CHIKV virus-like particle (CHIKV VLP) vaccine, was recently approved by regulators in the United States, European Union, and United Kingdom ...
Lark L. Coffey, Katherine J. Olstad, J. Rachel Reader, Amir Ardeshir, Christopher M. Weiss, Jennifer K. Watanabe, Jodie L. Usachenko, JoAnn Yee, Anil Singapuri, Zhong Min Ma, Alexis Mackiewicz, Rebecca Sammak, Jackson Stuart, Ramya Immareddy, Ravi Anantha, Kelly L. Warfield, Darly Manayani, Jeff Alexander, Jonathan Smith, Lo Vang, Christopher M. Cirimotich, Cassandra O’Connor, Ben Guenther, Nhuxuan Ho, Christopher S. Morello, Jason Mendy, Jason S. Richardson, Koen K. A. Van Rompay   +27 more
doaj   +1 more source

Chikungunya virus (CHIKV) induced disease signs.

, 2014
A. Pictures of the hind limbs of mock- and CHIKV-infected animals. Chikungunya virus infection induced severe hind limb disease in new born mice. 2–3 day old mice inoculated with 106 PFU (50 ul) of CHIKV by subcutaneous injection in the loose fold of ...
Mohsin Khan (352381), Vinay Lomash (542275), Putcha Venkata Lakshmana Rao (542276), Hinh Ly (349338), Manmohan Parida (206304), Rekha Dhanwani (542274)   +5 more
core   +1 more source

Identification of immunogenic and cross-reactive chikungunya virus epitopes for CD4+ T cells in chronic chikungunya disease

Nature Communications
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes acute febrile illness that can progress into chronic arthritis-like disease (CHIKVD) in humans.
Rimjhim Agarwal, Calvin Ha, Fernanda H. Côrtes, Yeji Lee, Amparo Martínez-Pérez, Rosa Isela Gálvez, Izabella N. Castillo, Elizabeth J. Phillips, Simon A. Mallal, Angel Balmaseda, Eva Harris, Claudia M. Romero-Vivas, Lakshmanane Premkumar, Andrew K. Falconar, Alba Grifoni, Alessandro Sette, Daniela Weiskopf   +16 more
doaj   +1 more source

Emetine dihydrochloride inhibits Chikungunya virus nsP2 helicase and shows robust antiviral activity in cells and mice

Journal of Biomedical Science
Background Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes frequent global epidemics of chikungunya fever, characterized by severe joint pain and debilitating arthritis.
Anshula Sharma, Chandru Subramani, K. A. Shouri, Ghanshyam Sharma, Brohmomoy Basu, Abhay Deep Pandey, Archana Rout, Devendra Sharma, Deepti Jain, Sudhanshu Vrati   +9 more
doaj   +1 more source

Attenuation of neurovirulence of chikungunya virus by a single amino acid mutation in viral E2 envelope protein

Journal of Biomedical Science
Background Chikungunya virus (CHIKV) has reemerged as a major public health concern, causing chikungunya fever with increasing cases and neurological complications.
Huixin Chen, Patchara Phuektes, Li Sze Yeo, Yi Hao Wong, Regina Ching Hua Lee, Bowen Yi, Xinjun Hou, Sen Liu, Yu Cai, Justin Jang Hann Chu   +9 more
doaj   +1 more source