Results 111 to 120 of about 1,052,896 (217)

Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response [PDF]

, 2015
International audienceRNA-sensing toll-like receptors (TLRs) mediate innate immunity and regulate anti-viral response. We show here that TLR3 regulates host immunity and the loss of TLR3 aggravates pathology in Chikungunya virus (CHIKV) infection ...
Ng, Lisa, Yiu‐Wing Kam, Wendy WL Lee, Gabriel, Christelle, Chow, A, Kam, Y.-W, Teck‐Hui Teo, Subhra K Biswas, Terk‐Shin Teng, Lulla, Valeria, Andres Merits, Leo, Y.-S, Teo, T.-H, Lulla, Aleksei, Win, M.K, Win, Mar, K, Angela Chow, Valeria Lulla, Laurent Rénia, Andiappan, A.K, Biswas, Subhra,, Yee‐Sin Leo, Biswas, Subhra, K, Marc Lecuit, Christelle Gabriel, Teng, Terk-Shin, Teo, Teck-Hui, Lulla, V, Lecuit, M, Zhisheng Her, Rossella Melchiotti, Gabriel, C, Leo, Yee-Sin, Mar K Win, Fok‐Moon Lum, Tan, Jeslin, Lee, Wendy,, Jeslin JL Tan, Lulla, A, Melchiotti, Rossella, Her, Zhisheng, Lee, W.W.L, Merits, Andres, Aleksei Lulla, Win, Mar,, Lee, Wendy, Wl, Kam, Yiu-Wing, Lecuit, Marc, Andiappan, Anand, K, Teng, T.-S, Lisa FP Ng, Anand K Andiappan, Merits, A, Biswas, S.K, Her, Z, Tan, J.J.L, Chow, Angela, Renia, Laurent, Melchiotti, R, Andiappan, Anand,, Lum, F.-M, Lum, Fok-Moon, Rénia, L, Ng, L.F.P   +63 more
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Development of the Live-Attenuated Chikungunya Virus Vaccine Candidate CHIKV-NoLS

, 2023
The causal pathogen of chikungunya virus disease, mosquito-transmitted chikungunya virus (CHIKV), has caused significant global epidemics of arthritic disease over the past two decades.
Rao, Shambhavi
core   +1 more source

Accurate Recapitulation of Chikungunya Virus Complete Coding Sequence Phylogeny Using Variable Genome Regions for Genomic Surveillance

Viruses
Chikungunya virus (CHIKV) is transmitted by mosquito bites and causes chikungunya fever (CHIKF). CHIKV has a single-stranded RNA genome and belongs to a single serotype with three genotypes.
Eduardo D. Rodríguez-Aguilar, Everardo Gutiérrez-Millán, Mario H. Rodríguez   +2 more
doaj   +1 more source

Expression and evaluation of Chikungunya virus E1 and E2 envelope proteins for serodiagnosis of Chikungunya virus infection. [PDF]

, 2008
PURPOSE: Chikungunya virus (CHIKV) causes endemic or epidemic outbreaks of CHIKV fever, which is a mosquitoe- transmitted viral disease in Africa, India, South-East Asia, and recently Southern Europe.
Kim, J, Cho, B, Park, S, Noh, J, Jeon, BY, Park, M   +5 more
core   +1 more source

Design and Validation of Novel Chikungunya Virus Protease Inhibitors [PDF]

, 2016
Chikungunya virus (CHIKV; genus Alphavirus) is the causative agent of chikungunya fever. CHIKV replication can be inhibited by some broad-spectrum antiviral compounds; in contrast, there is very little information about compounds specifically inhibiting ...
Ahola, Tero, Utt, Age, Merits, Andres, Karelson, Mati, Das, Pratyush Kumar, Lopp, Margus, Puusepp, Laura, Kananovich, Dzmitry G., Varghese, Finny S.   +8 more
core   +1 more source

Chikungunya Virus as Cause of Febrile Illness Outbreak, Chiapas, Mexico, 2014

Emerging Infectious Diseases, 2015
Since chikungunya virus (CHIKV) was introduced into the Americas in 2013, its geographic distribution has rapidly expanded. Of 119 serum samples collected in 2014 from febrile patients in southern Mexico, 79% were positive for CHIKV or IgM against CHIKV.
Tiffany F. Kautz, Esteban E. Díaz-González, Jesse H. Erasmus, Iliana R. Malo-García, Rose M. Langsjoen, Edward I. Patterson, Dawn I. Auguste, Naomi L. Forrester, Rosa Maria Sanchez-Casas, Mauricio Hernández-Ávila, Celia M. Alpuche-Aranda, Nikos Vasilakis, Ildefonso Fernández-Salas   +12 more
doaj   +1 more source

Imidazonaphthyridine effects on Chikungunya virus replication: Antiviral activity by dependent and independent of interferon type 1 pathways

, 2023
The Chikungunya virus (CHIKV) causes Chikungunya fever, a disease characterized by symptoms such as arthralgia/polyarthralgia. Currently, there are no antivirals approved against CHIKV, emphasizing the need to develop novel therapies.
Sabino-Silva, Robinson, Guevara-Vega, Marco, Grosche, Victória Riquena [UNESP], Torres, Jhoan David Aguillón, Nicolau-Junior, Nilson, Mineo, Tiago Wilson Patriarca, Freire, Marjorie Caroline Liberato Cavalcanti, Jardim, Ana Carolina Gomes [UNESP], Santos, Igor Andrade, Mesquita, Nathalya Cristina de Moraes Roso, Fernandes, Rafaela Sachetto, Ruiz, Uriel Enrique Aquino, Oliva, Glaucius, de Godoy, Andre Schutzer   +13 more
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Development of a serological assay for Chikungunya virus / Nishakanthi a/p Gopalan [PDF]

, 2008
Chikungunya virus (CHIKV) is a RNA virus that belongs to the Alphavirus genus of the family Togaviridae. It is transmitted by Aedes albopictus and Aedes aegypti, and causes clinical symptoms like fever with acute fever, skin rash and athralgia which ...
Gopalan, Nishakanthi
core  

Therapeutics and Vaccines Against Chikungunya Virus

, 2015
Erratum in Correction to: Vector Borne Zoonotic Dis 2015;15(4):250-257 DOI: 10.1089/vbz.2014.1681. [Vector Borne Zoonotic Dis. 2015]International audienceCurrently, there are no licensed vaccines or therapies available against chikungunya virus (CHIKV)
Ann Powers, Powers, A, Esteban, M, Esteban, Mariano, Mariano Esteban, Hallengärd, David, Couderc, Thérèse, Ng, Lisa F.P., Ng, LFP, Peter Liljeström, Merits, Andres, Roques, P, Liljeström, Peter, Andres Merits, Courderc, T, Lecuit, Marc, Therese Couderc, Liljestrom, P, Pierre Roques, Merits, A, Powers, Ann, Roques, Pierre, Marc Lecuit, Ahola, Tero, Lisa F.P. Ng, Lecuit, M, David Hallengärd, Tero Ahola, Hallengard, D, Ahola, T   +29 more
core   +1 more source

A chikungunya virus-like particle vaccine reduces chikungunya disease in cynomolgus macaques and protection is mediated by antibody transferred from vaccinated humans

npj Vaccines
Chikungunya virus (CHIKV) causes periodic outbreaks and is endemic in more than 110 countries. VIMKUNYA, a CHIKV virus-like particle (CHIKV VLP) vaccine, was recently approved by regulators in the United States, European Union, and United Kingdom ...
Lark L. Coffey, Katherine J. Olstad, J. Rachel Reader, Amir Ardeshir, Christopher M. Weiss, Jennifer K. Watanabe, Jodie L. Usachenko, JoAnn Yee, Anil Singapuri, Zhong Min Ma, Alexis Mackiewicz, Rebecca Sammak, Jackson Stuart, Ramya Immareddy, Ravi Anantha, Kelly L. Warfield, Darly Manayani, Jeff Alexander, Jonathan Smith, Lo Vang, Christopher M. Cirimotich, Cassandra O’Connor, Ben Guenther, Nhuxuan Ho, Christopher S. Morello, Jason Mendy, Jason S. Richardson, Koen K. A. Van Rompay   +27 more
doaj   +1 more source