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Autochthonous chikungunya virus (CHIKV) outbreak in the province of Modena, Emilia-Romagna region, Italy, August to October 2025: epidemiology, clinical features and virological findings [PDF]

Eurosurveillance
Between 10 August and 31 October 2025, 343 cases (306 confirmed and 37 probable) of symptomatic autochthonous chikungunya virus (CHIKV) infection were notified in eight municipalities in the province of Modena, Emilia-Romagna region, northern Italy.
on behalf of the Emilia-Romagna CHIKV outbreak group
doaj   +2 more sources

Suramin Inhibits Chikungunya Virus Replication by Interacting with Virions and Blocking the Early Steps of Infection

Viruses, 2020
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that can cause a debilitating disease that is primarily characterized by persistent joint pain. CHIKV has been emerging globally, while neither a vaccine nor antiviral medication is available.
Irina C. Albulescu, Leonie White-Scholten, Ali Tas, Tabitha E. Hoornweg, Salvatore Ferla, Kristina Kovacikova, Jolanda M. Smit, Andrea Brancale, Eric J. Snijder, Martijn J. van Hemert   +9 more
doaj   +1 more source

Development of a next-generation chikungunya virus vaccine based on the HydroVax platform.

PLoS Pathogens, 2022
Chikungunya virus (CHIKV) is an emerging/re-emerging mosquito-borne pathogen responsible for explosive epidemics of febrile illness characterized by debilitating polyarthralgia and the risk of lethal infection among the most severe cases.
Dawn K Slifka, Hans-Peter Raué, Whitney C Weber, Takeshi F Andoh, Craig N Kreklywich, Victor R DeFilippis, Daniel N Streblow, Mark K Slifka, Ian J Amanna   +8 more
doaj   +1 more source

Expression of plasmid-based shRNA against the E1 and nsP1 genes effectively silenced Chikungunya virus replication. [PDF]

PLoS ONE, 2012
BACKGROUND: Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes chikungunya fever and persistent arthralgia in humans. Currently, there is no effective vaccine or antiviral against CHIKV infection.
Shirley Lam, Karen Caiyun Chen, Mary Mah-Lee Ng, Justin Jang Hann Chu   +3 more
doaj   +1 more source

Pathogenetic Potential Relating to Metabolic Activity in a Mouse Model of Infection with the Chikungunya Virus East/Central/South African Genotype

Viruses, 2020
Epidemics of the Chikungunya virus (CHIKV) from 2004 onwards were caused by the East/Central/South African (ECSA) genotype. However, the pathogenesis of the genotype infection has not been fully explained.
Mya Myat Ngwe Tun, Rohitha Muthugala, Aung Kyaw Kyaw, Satoshi Shimada, Kouichi Morita, Daisuke Hayasaka   +5 more
doaj   +1 more source

Sero-prevalence and cross-reactivity of chikungunya virus specific anti-E2EP3 antibodies in arbovirus-infected patients. [PDF]

PLoS Neglected Tropical Diseases, 2015
Chikungunya virus (CHIKV) and clinically-related arboviruses cause large epidemics with serious economic and social impact. As clinical symptoms of CHIKV infections are similar to several flavivirus infections, good detection methods to identify CHIKV ...
Yiu-Wing Kam, Kwoon-Yong Pok, Kai Er Eng, Li-Kiang Tan, Simrandeep Kaur, Wendy W L Lee, Yee-Sin Leo, Lee-Ching Ng, Lisa F P Ng   +8 more
doaj   +1 more source

Luciferase Immunosorbent Assay Based on Multiple E Antigens for the Detection of Chikungunya Virus-Specific IgG Antibodies

Microbiology Spectrum, 2022
In recent years, the chikungunya virus (CHIKV) has continued to spread from local epidemics to nonnative habitats until eventually reaching pandemic status.
Xiaoxia Li, Xuan Wan, Jinyue Liu, Haiying Wang, Anan Li, Changwen Ke, Shixing Tang, Wei Zhao, Shaoxi Cai, Chengsong Wan   +9 more
doaj   +1 more source

Construction and Evaluation of Recombinant Adenovirus Candidate Vaccines for Chikungunya Virus

Viruses, 2022
Chikungunya virus (CHIKV) is a mosquito-borne virus. The emergence of CHIKV infection has raised global concern, and there is a growing need to develop safe and effective vaccines.
Liang Cao, Wei Wang, Wenchao Sun, Jinyong Zhang, Jicheng Han, Changzhan Xie, Zhuo Ha, Yubiao Xie, He Zhang, Ningyi Jin, Huijun Lu   +10 more
doaj   +1 more source

Liposomal Delivery of the RNA Genome of a Live-Attenuated Chikungunya Virus Vaccine Candidate Provides Local, but Not Systemic Protection After One Dose

Frontiers in Immunology, 2020
Chikungunya virus (CHIKV) is the causative pathogen of chikungunya fever, a mosquito-borne viral disease causing highly debilitating arthralgia that can persist for months and progress to chronic arthritis.
Eranga Abeyratne, Eranga Abeyratne, Kothila Tharmarajah, Kothila Tharmarajah, Joseph R. Freitas, Joseph R. Freitas, Helen Mostafavi, Helen Mostafavi, Suresh Mahalingam, Suresh Mahalingam, Ali Zaid, Ali Zaid, Mehfuz Zaman, Adam Taylor, Adam Taylor   +14 more
doaj   +1 more source

Loss of Glycosaminoglycan Receptor Binding after Mosquito Cell Passage Reduces Chikungunya Virus Infectivity. [PDF]

PLoS Neglected Tropical Diseases, 2015
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that can cause fever and chronic arthritis in humans. CHIKV that is generated in mosquito or mammalian cells differs in glycosylation patterns of viral proteins, which may affect its ...
Dhiraj Acharya, Amber M Paul, John F Anderson, Faqing Huang, Fengwei Bai   +4 more
doaj   +1 more source