Attenuation and Stability of CHIKV-NoLS, a Live-Attenuated Chikungunya Virus Vaccine Candidate
Vaccines, 2018 Our previous investigation of the nucleolar localisation sequence (NoLS) of chikungunya virus (CHIKV) capsid protein demonstrated the role of capsid in CHIKV virulence.
Eranga Abeyratne +4 more
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Stability of CHIKV infection models with CHIKV-monocyte and infected-monocyte saturated incidences [PDF]
AIP Advances, 2019 We study the global stability of within-host Chikungunya virus (CHIKV) infection models with antibodies. We incorporate two modes of infections, attaching a CHIKV to a host monocyte, and contacting an infected monocyte with an uninfected monocyte. The CHIKV-monocyte and infected-monocyte incidence rates are given by saturation.
A. M. Elaiw, S. E. Almalki, A. D. Hobiny
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Infectious Chikungunya Virus (CHIKV) with a Complete Capsid Deletion: a New Approach for a CHIKV Vaccine [PDF]
Journal of Virology, 2019 Currently, there is no licensed vaccine against CHIKV infection. An ideal CHIKV vaccine should generate an optimal balance between efficacy and safety. Live attenuated vaccines that can elicit strong immune responses often involve a trade-off of reduced safety. Here, a novel live attenuated vaccine candidate for CHIKV lacking the entire capsid gene, ΔC-
Ya-Nan Zhang +7 more
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A booster regime of liposome-delivered live-attenuated CHIKV vaccine RNA genome protects against chikungunya virus disease in mice [PDF]
, 2023 Mosquito-transmitted chikungunya virus (CHIKV) is the causal pathogen of CHIKV disease and is responsible for global epidemics of arthritic disease. CHIKV infection can lead to severe chronic and debilitating arthralgia, significantly impacting patient ...
Abeyratne, E +21 more
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Analysis of Humoral Immune Responses in Chikungunya Virus (CHIKV)-Infected Patients and Individuals Vaccinated With a Candidate CHIKV Vaccine [PDF]
The Journal of Infectious Diseases, 2019 Abstract Background Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes severe flu-like symptoms. The acute symptoms disappear after 1 week, but chronic arthralgia can persist for years.
Lisa Henss +7 more
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Cutaneous manifestations in six children by CHIKV: a case series
Residência Pediátrica, 2023 OBJECTIVES: To describe a case series of children diagnosed with Chikungunya virus (CHIKV) infection with atypical dermatologic manifestations, in order to broaden the picture of possibilities for differential diagnoses in cases of similar clinical presentations.
Hellen Moura +7 more
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Evaluation of novobiocin and telmisartan for anti-CHIKV activity
Virology, 2020 Chikungunya has re-emerged as an epidemic with global distribution and high morbidity, necessitating the need for effective therapeutics. We utilized already approved drugs with a good safety profile used in other diseases for their new property of anti-chikungunya activity.
Praveen Kumar, Tripathi +10 more
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Development and Application of Treatment for Chikungunya Fever
Research and Reports in Tropical Medicine, 2022 Erin M Millsapps, Emma C Underwood, Kelli L Barr Center for Global Health and Infectious Disease Research, University of South Florida, Tampa, FL, USACorrespondence: Kelli L Barr, Center for Global Health and Infectious Disease Research, University of ...
Millsapps EM, Underwood EC, Barr KL
doaj
CHIKV-infected human macrophages show a more robust pro-inflammatory profile.
, 2020 Cytokine expression in CHIKV-infected human and murine macrophages was quantified by cytometric bead arrays at 24 hpi. Data show mean values of three independent experiments with a total of n = 9, MOI = 5.
E. Shannon Tass (8566689) +4 more
core +1 more source
Preparation and application of chikungunya pseudovirus containing double reporter genes
Scientific Reports, 2022 Chikungunya virus (CHIKV), a highly infectious and rapidly spread viral pathogen, is classified as a pathogenic agent at the biosafety level 3. Operation of live authentic CHIKV needs a specific laboratory with the P3 or above containment, which greatly ...
Chunyan Su +7 more
doaj +1 more source