Results 21 to 30 of about 15,961 (231)

HydroVax-CHIKV vaccination protects against viremia and virus-associated arthritic disease following heterologous CHIKV challenge.

, 2022
Purified CHIKV-181/25 was inactivated with the optimized HydroVax approach (20 hours at room temperature), heat inactivation (HI-CHIKV, 1 hour at 80°C) or ultraviolet irradiation (UV, 10J).
Whitney C. Weber (8566797), Hans-Peter Raué (13001988), Mark K. Slifka (13001991), Dawn K. Slifka (13001985), Craig N. Kreklywich (7592762), Ian J. Amanna (13001994), Victor R. DeFilippis (8496240), Daniel N. Streblow (7592771), Takeshi F. Andoh (8299272)   +8 more
core   +1 more source

Development of Neutralization Assay Using an eGFP Chikungunya Virus

Viruses, 2016
Chikungunya virus (CHIKV), a member of the Alphavirus genus, is an important human emerging/re-emerging pathogen. Currently, there are no effective antiviral drugs or vaccines against CHIKV infection. Herein, we construct an infectious clone of CHIKV and
Cheng-Lin Deng, Si-Qing Liu, Dong-Gen Zhou, Lin-Lin Xu, Xiao-Dan Li, Pan-Tao Zhang, Peng-Hui Li, Han-Qing Ye, Hong-Ping Wei, Zhi-Ming Yuan, Cheng-Feng Qin, Bo Zhang   +11 more
doaj   +1 more source

Large-scale outbreak of Chikungunya virus infection in Thailand, 2018-2019.

PLoS ONE, 2021
Between 2018 and 2019, the incidence of chikungunya was approximately 15,000 cases across 60 provinces in Thailand. Here, the clinical presentations in chikungunya, emergent pattern, and genomic diversity of the chikungunya virus (CHIKV) causing this ...
Sarawut Khongwichit, Jira Chansaenroj, Thanunrat Thongmee, Saovanee Benjamanukul, Nasamon Wanlapakorn, Chintana Chirathaworn, Yong Poovorawan   +6 more
doaj   +1 more source

Immune Response to Chikungunya Virus: Sex as a Biological Variable and Implications for Natural Delivery via the Mosquito

Viruses, 2023
Chikungunya virus (CHIKV) is a mosquito-borne virus with significant public health implications around the world. Climate change, as well as rapid urbanization, threatens to expand the population range of Aedes vector mosquitoes globally, increasing ...
Meagan Taylor, Jonathan O. Rayner
doaj   +1 more source

Mutation of the N-Terminal Region of Chikungunya Virus Capsid Protein: Implications for Vaccine Design

mBio, 2017
Mosquito-transmitted chikungunya virus (CHIKV) is an arthritogenic alphavirus of the Togaviridae family responsible for frequent outbreaks of arthritic disease in humans.
Adam Taylor, Xiang Liu, Ali Zaid, Lucas Y. H. Goh, Jody Hobson-Peters, Roy A. Hall, Andres Merits, Suresh Mahalingam   +7 more
doaj   +1 more source

Evidence of Chikungunya virus seroprevalence in Myanmar among dengue-suspected patients and healthy volunteers in 2013, 2015, and 2018.

PLoS Neglected Tropical Diseases, 2021
IntroductionChikungunya virus (CHIKV) is a mosquito-borne virus known to cause acute febrile illness associated with debilitating polyarthritis. In 2019, several institutions in Myanmar reported a CHIKV outbreak.
Elizabeth Ajema Chebichi Luvai, Aung Kyaw Kyaw, Nundu Sabiti Sabin, Fuxun Yu, Saw Wut Hmone, Kyaw Zin Thant, Shingo Inoue, Kouichi Morita, Mya Myat Ngwe Tun   +8 more
doaj   +1 more source

Evidence for endemic chikungunya virus infections in Bandung, Indonesia. [PDF]

PLoS Neglected Tropical Diseases, 2013
Chikungunya virus (CHIKV) is known to cause sporadic or explosive outbreaks. However, little is known about the endemic transmission of CHIKV. To ascertain the endemic occurrence of CHIKV transmission, we tested blood samples from patients with a non ...
Herman Kosasih, Quirijn de Mast, Susana Widjaja, Primal Sudjana, Ungke Antonjaya, Chairin Ma'roef, Silvita Fitri Riswari, Kevin R Porter, Timothy H Burgess, Bachti Alisjahbana, Andre van der Ven, Maya Williams   +11 more
doaj   +1 more source

A Case of Initially Undiagnosed Chikungunya Arthritis Developing into Chronic Phase in a Nonendemic Area

Case Reports in Medicine, 2017
This case report described a 40-year-old lady presented with fever, headache, arthralgia, myalgia, and impaired liver function after returning from the Philippines. Chikungunya virus (CHIKV) and dengue serology were negative.
Pui Shan Julia Chan, Moon Ho Leung
doaj   +1 more source

Diagnostic Methods for CHIKV Based on Serological Tools

, 2016
This chapter presents the most commonly used serological methods for the diagnosis of Chikungunya virus (CHIKV) infection in humans. CHIKV is a mosquito-borne Alphavirus widely distributed in the tropical and subtropical regions of Africa, Asia, and America.
GAIBANI, PAOLO, Landini, Maria Paola, SAMBRI, VITTORIO   +2 more
openaire   +3 more sources

Detection of Chikungunya virus (CHIKV) in urine of infected mice: a Potential Non-invasive Diagnostic Tool for CHIKV

Journal of Infectious Diseases & Therapy, 2015
Background: The reemergence of Chikungunya virus (CHIKV) infection and the spread of the virus throughout the world call for a fast, reliable, and improved laboratory diagnostic procedures. The aim of this study was to determine if CHIKV genome is present in other body fluids besides plasma as a tool for developing non-invasive diagnostic method ...
Jones PH, Okeoma CM
openaire   +1 more source