Results 71 to 80 of about 10,808 (171)

Universal Regulation of DNA Polymerase via Photocaged Primer Enables Light‐Start Isothermal Amplification on Demand

Advanced Science, Volume 13, Issue 3, 14 January 2026.
A simple and general photoactivatable approach is developed to regulate DNA polymerase activity, enabling light‐start isothermal amplification on demand. The molecular dynamics simulations reveals that the photocaged primer blocks DNA polymerase activity by inhibiting the conformational change of the polymerase.
Min Qing, Yufan Qin, Zhijin Li, Xiufang Yu, Jianbo Wang, Xiaoqiong Liu, Xin Chen, Chao Yu   +7 more
wiley   +1 more source

Chikungunya Virus and Zika Virus in Europe

, 2018
Chikungunya fever epidemics display secular, cyclical, and seasonal trends. These epidemics are characterized by explosive outbreaks inter- spersed by periods of disappearance ranging from several years to a few decades.
MARTINA TASSINARI, CLAUDIA CHIESA, SILVIA ZANNOLI, VITTORIO SAMBRI, AGNESE DENICOLÒ, ANNA PIERRO, MANUELA MOROTTI   +6 more
core   +1 more source

The reappearance of Chikungunya virus in Bangladesh, 2024

Objectives We investigated a new outbreak of Chikungunya virus (CHIKV) in Dhaka and nearby areas of Bangladesh in 2024, examining its epidemiology, clinical features, and genomic characteristics. Methods
Khan, Manjur Hossain, Rahman, Mahbubur, Hassan, Mohammad Rashedul, Nasif, Md. Abdullah Omar, Prince, Kyaw Thowai Prue, Shirin, Tahmina, Haider, Najmul, Alam, Ahmed Nawsher, Hasan, Mohammad Nayeem, Rudra, Mithun, Sultana, Sharmin, Muntasir, Immamul, Ferdous, Jannatul, Qayum, Md. Omar   +13 more
core   +1 more source

Genetic characterization of the complete genome of a strain of Chikungunya virus circulating in Brazil

, 2023
El virus Chikungunya (CHIKV) es un virus de ARN monocatenario de sentido positivo que pertenece al género Alphavirus de la familia Togaviridae. Se transmite principalmente por mosquitos Aedes aegypti y albopictus.
Villarreal Julio, Rafael Guillermo, Yepes-Blandón, Jonny Andrés   +1 more
core   +1 more source

Chikungunya virus outbreak expansion and microevolutionary events affecting epidemiology and epidemic potential

, 2015
Ann M PowersArboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USAAbstract: Chikungunya virus (CHIKV) is a mosquito-borne virus that is associated with severe and prolonged ...
Powers AM
core  

Seroprevalence of Dengue Virus (DV), West Nile virus (WNV), Chikungunya virus (CHIKV) and Zika virus (ZV) in Italian international travelers

, 2017
Seroprevalence of Dengue Virus (DV), West Nile virus (WNV), Chikungunya virus (CHIKV) and Zika virus (ZV) in Italian international ...
D. Casulli, A. Metallo, A. L. De Robertis, D. A. Pepe, M. Chironna, D. Loconsole, A. Morea   +6 more
core  

Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response

, 2015
International audienceRNA-sensing toll-like receptors (TLRs) mediate innate immunity and regulate anti-viral response. We show here that TLR3 regulates host immunity and the loss of TLR3 aggravates pathology in Chikungunya virus (CHIKV) infection ...
Ng, Lisa, Yiu‐Wing Kam, Wendy WL Lee, Gabriel, Christelle, Chow, A, Kam, Y.-W, Teck‐Hui Teo, Subhra K Biswas, Terk‐Shin Teng, Lulla, Valeria, Andres Merits, Leo, Y.-S, Teo, T.-H, Lulla, Aleksei, Win, M.K, Win, Mar, K, Angela Chow, Valeria Lulla, Laurent Rénia, Andiappan, A.K, Biswas, Subhra,, Yee‐Sin Leo, Biswas, Subhra, K, Marc Lecuit, Christelle Gabriel, Teng, Terk-Shin, Teo, Teck-Hui, Lulla, V, Lecuit, M, Zhisheng Her, Rossella Melchiotti, Gabriel, C, Leo, Yee-Sin, Mar K Win, Fok‐Moon Lum, Tan, Jeslin, Lee, Wendy,, Jeslin JL Tan, Lulla, A, Melchiotti, Rossella, Her, Zhisheng, Lee, W.W.L, Merits, Andres, Aleksei Lulla, Win, Mar,, Lee, Wendy, Wl, Kam, Yiu-Wing, Lecuit, Marc, Andiappan, Anand, K, Teng, T.-S, Lisa FP Ng, Anand K Andiappan, Merits, A, Biswas, S.K, Her, Z, Tan, J.J.L, Chow, Angela, Renia, Laurent, Melchiotti, R, Andiappan, Anand,, Lum, F.-M, Lum, Fok-Moon, Rénia, L, Ng, L.F.P   +63 more
core   +1 more source

Chikungunya Virus in Macaques, Malaysia [PDF]

, 2015
In the past 10 years, chikungunya virus (CHIKV) has caused global epidemics of fever, rash, and arthralgia affecting millions of humans, most recently in the Americas (1). CHIKV is an alphavirus transmitted by Aedes spp. mosquitoes.
Frankie Thomas Sitam, Sam, I-Ching, Sitam, Frankie Thomas, Tong, Charmaine, Chan, Yoke Fun, Fu, Jolene Y.L., Chua, Chong Long, Jeffrine J. Rovie-Ryan, Charmaine Tong, Yoke Fun Chan, Jolene Y.L. Fu, I-Ching Sam, Chong Long Chua, Rovie-Ryan, Jeffrine J.   +13 more
core   +1 more source

Transcriptome analysis of human macrophages upon chikungunya virus (CHIKV) infection reveals regulation of distinct signaling and metabolic pathways during the early and late stages of infection. [PDF]

Heliyon, 2023
Srivastava P, Chaudhary S, Malhotra S, Varma B, Sunil S.   +4 more
europepmc   +1 more source

Design and Validation of Novel Chikungunya Virus Protease Inhibitors

, 2016
Chikungunya virus (CHIKV; genus Alphavirus) is the causative agent of chikungunya fever. CHIKV replication can be inhibited by some broad-spectrum antiviral compounds; in contrast, there is very little information about compounds specifically inhibiting ...
Ahola, Tero, Utt, Age, Merits, Andres, Karelson, Mati, Das, Pratyush Kumar, Lopp, Margus, Puusepp, Laura, Kananovich, Dzmitry G., Varghese, Finny S.   +8 more
core   +1 more source