Results 71 to 80 of about 15,637 (220)

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Chikungunya Virus in Febrile Humans and Aedes aegypti Mosquitoes, Yucatan, Mexico

Emerging Infectious Diseases, 2016
Chikungunya virus (CHIKV) was isolated from 12 febrile humans in Yucatan, Mexico, in 2015. One patient was co-infected with dengue virus type 1. Two additional CHIKV isolates were obtained from Aedes aegypti mosquitoes collected in the homes of patients.
Nohemi Cigarroa-Toledo, Bradley J. Blitvich, Rosa C. Cetina-Trejo, Lourdes G. Talavera-Aguilar, Carlos M. Baak-Baak, Oswaldo M. Torres-Chablé, Md-Nafiz Hamid, Iddo Friedberg, Pedro González-Martinez, Gabriela Alonzo-Salomon, Elsy P. Rosado-Paredes, Nubia Rivero-Cárdenas, Guadalupe C. Reyes-Solis, Jose A. Farfan-Ale, Julian E. Garcia-Rejon, Carlos Machain-Williams   +15 more
doaj   +1 more source

Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate

Scientific Reports, 2022
Chikungunya virus (CHIKV) is the causative agent of Chikungunya fever, an acute febrile and arthritogenic illness with no effective treatments available. The development of effective therapeutic strategies could be significantly accelerated with detailed
Marjorie C. L. C. Freire, Luis G. M. Basso, Luis F. S. Mendes, Nathalya C. M. R. Mesquita, Melina Mottin, Rafaela S. Fernandes, Lucca R. Policastro, Andre S. Godoy, Igor A. Santos, Uriel E. A. Ruiz, Icaro P. Caruso, Bruna K. P. Sousa, Ana C. G. Jardim, Fabio C. L. Almeida, Laura H. V. G. Gil, Carolina H. Andrade, Glaucius Oliva   +16 more
doaj   +1 more source

Antiviral activity of silymarin against chikungunya virus [PDF]

, 2015
Citation: Lani, R., Hassandarvish, P., Chiam, C. W., Moghaddam, E., Chu, J. J. H., Rausalu, K., . . . Zandi, K. (2015). Antiviral activity of silymarin against chikungunya virus. Scientific Reports, 5, 10.
Abu Bakar, S., Chiam, C. W., Chu, J. J. H., Hassandarvish, P., Higgs, Stephen, Lani, R., Merits, A., Moghaddam, E., Rausalu, K., Vanlandingham, Dana, Zandi, K.   +10 more
core   +1 more source

Development of a Reverse Transcription Recombinase Polymerase Amplification CRISPR/Cas12a Assay for Visual and Highly Specific Identification of Zika Virus

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Zika virus (ZIKV), a single‐stranded positive‐sense RNA virus of the Flaviviridae family (Flavivirus genus), causes acute febrile illness and severe congenital anomalies. Serological cross‐reactivity with Dengue virus (DENV) and Chikungunya virus (CHIKV) complicates diagnosis, underscoring the urgency of developing specific point‐of‐care tests
Xiao Cong, Xin Zhang, Feng Gu, Ningxin Tan, Shen Huang, Penghui Jia, Juan Su, Changyun Sun, Qiqi Tan, Ling Fang, Jieling Wang, Jin Yan, Chao Yu, Baisheng Li, Junqi Huang   +14 more
wiley   +1 more source

Chikungunya Virus Diagnosis: A Review of Current Antigen Detection Methods

Tropical Medicine and Infectious Disease, 2023
Chikungunya is a mosquito-borne viral disease caused by the chikungunya virus (CHIKV). CHIKV is expanding at an alarming rate, potentially spreading and establishing endemicity in new areas where competent vectors are present.
Fredy Brice Nemg Simo, Felicity Jane Burt, Nigel Aminake Makoah   +2 more
doaj   +1 more source

Photochemical inactivation of chikungunya virus in human apheresis platelet components by amotosalen and UVA light [PDF]

, 2013
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that recently re-emerged in Africa and rapidly spread into countries of the Indian Ocean basin and South-East Asia.
Higgs, Stephen, Kinsey, John, Sampson-Johannes, Adam, Sawyer, Lynette, Tsetsarkin, Konstantin A., Vanlandingham, Dana L.   +5 more
core   +1 more source

Meeting Report: Fourth Correlates of Protection for Next Generation Influenza Vaccines

Influenza and Other Respiratory Viruses, Volume 20, Issue 4, April 2026.
ABSTRACT Background This report summarizes the discussions and conclusions from the fourth “Correlates of Protection for Next Generation Influenza Vaccines” meeting, which took place in Vienna, Austria, from October 15, 2025, to October 17, 2025. Conclusion Discussions on influenza virus correlates of protection built on prior meetings, with particular
Alina Tscherne, Rebecca Jane Cox, Florian Krammer, Anders Bonnevie   +3 more
wiley   +1 more source

Urban socioeconomic, vegetation, and mosquito interactions in the United States: Current research and future directions

Ecosphere, Volume 17, Issue 3, March 2026.
Abstract With the introduction and adaptation of non‐native mosquitoes to cities, vector‐borne diseases are emerging concerns in the United States of America. A growing body of literature suggests that mosquito infestations and associated diseases are a greater burden in socioeconomically disadvantaged areas within the heterogeneous urban ecosystem ...
Sarah E. Rothman, Shannon L. LaDeau, Paul T. Leisnham   +2 more
wiley   +1 more source

HLA class I restriction as a possible driving force for Chikungunya evolution.

PLoS ONE, 2010
After two decades of quiescence, epidemic resurgence of Chikungunya fever (CHIKF) was reported in Africa, several islands in the Indian Ocean, South-East Asia and the Pacific causing unprecedented morbidity with some cases of fatality. Early phylogenetic
Joo Chuan Tong, Diane Simarmata, Raymond T P Lin, Laurent Rénia, Lisa F P Ng   +4 more
doaj   +1 more source