Infectious Chikungunya Virus (CHIKV) with a Complete Capsid Deletion: a New Approach for a CHIKV Vaccine [PDF]
Journal of Virology, 2019 Currently, there is no licensed vaccine against CHIKV infection. An ideal CHIKV vaccine should generate an optimal balance between efficacy and safety. Live attenuated vaccines that can elicit strong immune responses often involve a trade-off of reduced ...
Yanan Zhang +7 more
semanticscholar +3 more sources
Stability of CHIKV infection models with CHIKV-monocyte and infected-monocyte saturated incidences [PDF]
AIP Advances, 2019 We study the global stability of within-host Chikungunya virus (CHIKV) infection models with antibodies. We incorporate two modes of infections, attaching a CHIKV to a host monocyte, and contacting an infected monocyte with an uninfected monocyte.
A. Elaiw, S. E. Almalki, A. Hobiny
semanticscholar +3 more sources
Analysis of humoral immune responses in chikungunya virus (CHIKV) infected patients and individuals vaccinated with a candidate CHIKV vaccine. [PDF]
The Journal of Infectious Diseases, 2019 BACKGROUND Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes severe flu like symptoms. The acute symptoms disappear after one week, but chronic arthralgia can persist for years.
Lisa Henss +7 more
semanticscholar +4 more sources
Discovery of Mosquito Saliva MicroRNAs during CHIKV Infection
PLOS Neglected Tropical Diseases, 2015 Mosquito borne pathogens are transmitted to humans via saliva during blood feeding. Mosquito saliva is a complex concoction of many secretory factors that modulate the feeding foci to enhance pathogen infection and establishment.
Payal D Maharaj +4 more
semanticscholar +5 more sources
Chikungunya virus (CHIKV) inhibitors from natural sources: a medicinal chemistry perspective [PDF]
Journal of Natural Medicines, 2015 Chikungunya virus (CHIKV) is one of the re-emerging “neglected” tropical diseases whose recent outbreak affected not only Africa and South-East Asia but also several parts of America and Europe.
S. Bhakat, M. Soliman
semanticscholar +3 more sources
Virology, 2013 Chikungunya virus (CHIKV) is a re-emerging alphavirus transmitted by Aedes mosquitoes. Infection with CHIKV elicits a type I interferon response that facilities virus clearance, probably through the action of down-stream effectors such as antiviral IFN-stimulated genes (ISGs).
P. Jones +5 more
semanticscholar +3 more sources
Cutaneous manifestations in six children by CHIKV: a case series
Residência Pediátrica, 2023 OBJECTIVES: To describe a case series of children diagnosed with Chikungunya virus (CHIKV) infection with atypical dermatologic manifestations, in order to broaden the picture of possibilities for differential diagnoses in cases of similar clinical presentations.
Hellen Moura +7 more
openalex +2 more sources
Nature Communications, 2022 Ample evidence indicates that codon usage bias regulates gene expression. How viruses, such as the emerging mosquito-borne Chikungunya virus (CHIKV), express their genomes at high levels despite an enrichment in rare codons remains a puzzling question ...
J. Jungfleisch +6 more
semanticscholar +1 more source
Co-Immunization With CHIKV VLP and DNA Vaccines Induces a Promising Humoral Response in Mice
Frontiers in Immunology, 2021 Chikungunya fever is an acute infectious disease that is mediated by the mosquito-transmitted chikungunya virus (CHIKV), for which no licensed vaccines are currently available.
Zhimin Zhao +10 more
semanticscholar +1 more source
Nonstructural Protein 2 (nsP2) of Chikungunya Virus (CHIKV) Enhances Protective Immunity Mediated by a CHIKV Envelope Protein Expressing DNA Vaccine [PDF]
Viral Immunology, 2013 Chikungunya virus (CHIKV) is an important emerging mosquito-borne alphavirus, indigenous to tropical Africa and Asia. It can cause epidemic fever and acute illness characterized by fever and arthralgias. The epidemic cycle of this infection is similar to dengue and urban yellow fever viral infections.
H. Bao +11 more
semanticscholar +4 more sources