Results 21 to 30 of about 14,798 (236)

Development of a next-generation chikungunya virus vaccine based on the HydroVax platform.

PLoS Pathogens, 2022
Chikungunya virus (CHIKV) is an emerging/re-emerging mosquito-borne pathogen responsible for explosive epidemics of febrile illness characterized by debilitating polyarthralgia and the risk of lethal infection among the most severe cases.
Dawn K Slifka, Hans-Peter Raué, Whitney C Weber, Takeshi F Andoh, Craig N Kreklywich, Victor R DeFilippis, Daniel N Streblow, Mark K Slifka, Ian J Amanna   +8 more
doaj   +1 more source

Suramin Inhibits Chikungunya Virus Replication by Interacting with Virions and Blocking the Early Steps of Infection

Viruses, 2020
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that can cause a debilitating disease that is primarily characterized by persistent joint pain. CHIKV has been emerging globally, while neither a vaccine nor antiviral medication is available.
Irina C. Albulescu, Leonie White-Scholten, Ali Tas, Tabitha E. Hoornweg, Salvatore Ferla, Kristina Kovacikova, Jolanda M. Smit, Andrea Brancale, Eric J. Snijder, Martijn J. van Hemert   +9 more
doaj   +1 more source

Expression of plasmid-based shRNA against the E1 and nsP1 genes effectively silenced Chikungunya virus replication. [PDF]

PLoS ONE, 2012
BACKGROUND: Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes chikungunya fever and persistent arthralgia in humans. Currently, there is no effective vaccine or antiviral against CHIKV infection.
Shirley Lam, Karen Caiyun Chen, Mary Mah-Lee Ng, Justin Jang Hann Chu   +3 more
doaj   +1 more source

Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP.

Molecules and Cells, 2020
The primary interactions between incoming viral RNA genomes and host proteins are crucial to infection and immunity. Until now, the ability to study these events was lacking.
Byungil Kim, Sarah Arcos, K. Rothamel, Jeffrey Y Jian, K. Rose, W. McDonald, Yuqi Bian, Seth Andrew Reasoner, Nicholas J. Barrows, Shelton S Bradrick, M. Garcia-Blanco, M. Ascano   +11 more
semanticscholar   +1 more source

Pathogenetic Potential Relating to Metabolic Activity in a Mouse Model of Infection with the Chikungunya Virus East/Central/South African Genotype

Viruses, 2020
Epidemics of the Chikungunya virus (CHIKV) from 2004 onwards were caused by the East/Central/South African (ECSA) genotype. However, the pathogenesis of the genotype infection has not been fully explained.
Mya Myat Ngwe Tun, Rohitha Muthugala, Aung Kyaw Kyaw, Satoshi Shimada, Kouichi Morita, Daisuke Hayasaka   +5 more
doaj   +1 more source

Luciferase Immunosorbent Assay Based on Multiple E Antigens for the Detection of Chikungunya Virus-Specific IgG Antibodies

Microbiology Spectrum, 2022
In recent years, the chikungunya virus (CHIKV) has continued to spread from local epidemics to nonnative habitats until eventually reaching pandemic status.
Xiaoxia Li, Xuan Wan, Jinyue Liu, Haiying Wang, Anan Li, Changwen Ke, Shixing Tang, Wei Zhao, Shaoxi Cai, Chengsong Wan   +9 more
doaj   +1 more source

Sero-prevalence and cross-reactivity of chikungunya virus specific anti-E2EP3 antibodies in arbovirus-infected patients. [PDF]

PLoS Neglected Tropical Diseases, 2015
Chikungunya virus (CHIKV) and clinically-related arboviruses cause large epidemics with serious economic and social impact. As clinical symptoms of CHIKV infections are similar to several flavivirus infections, good detection methods to identify CHIKV ...
Yiu-Wing Kam, Kwoon-Yong Pok, Kai Er Eng, Li-Kiang Tan, Simrandeep Kaur, Wendy W L Lee, Yee-Sin Leo, Lee-Ching Ng, Lisa F P Ng   +8 more
doaj   +1 more source

Loss of Glycosaminoglycan Receptor Binding after Mosquito Cell Passage Reduces Chikungunya Virus Infectivity. [PDF]

PLoS Neglected Tropical Diseases, 2015
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that can cause fever and chronic arthritis in humans. CHIKV that is generated in mosquito or mammalian cells differs in glycosylation patterns of viral proteins, which may affect its ...
Dhiraj Acharya, Amber M Paul, John F Anderson, Faqing Huang, Fengwei Bai   +4 more
doaj   +1 more source

Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus [PDF]

, 2018
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Aquilimeba, Muriel, Kasvandik, Sergo, Lulla, Aleksei, Lulla, Valeria, McInerney, Gerald M., Merits, Andres, Morro, Ainhoa Moliner, Mutso, Margit, Saul, Sirle, Smedberg, Cecilia, Tarve, Liisi, Teppor, Mona, Thaa, Bastian, Varjak, Margus   +13 more
core   +3 more sources

Liposomal Delivery of the RNA Genome of a Live-Attenuated Chikungunya Virus Vaccine Candidate Provides Local, but Not Systemic Protection After One Dose

Frontiers in Immunology, 2020
Chikungunya virus (CHIKV) is the causative pathogen of chikungunya fever, a mosquito-borne viral disease causing highly debilitating arthralgia that can persist for months and progress to chronic arthritis.
Eranga Abeyratne, Eranga Abeyratne, Kothila Tharmarajah, Kothila Tharmarajah, Joseph R. Freitas, Joseph R. Freitas, Helen Mostafavi, Helen Mostafavi, Suresh Mahalingam, Suresh Mahalingam, Ali Zaid, Ali Zaid, Mehfuz Zaman, Adam Taylor, Adam Taylor   +14 more
doaj   +1 more source