Results 91 to 100 of about 17,977,226 (311)

Child Psychiatric Disorders Presenting to a Tertiary Multidisciplinary Child Development Service in Bangladesh

Bangladesh Journal of Child Health, 2012
Background: Shishu Bikash Kendra (SBK or Child Development Center) of the Dhaka Shishu (Children’s) Hospital (DSH) has been using a multidisciplinary approach for assessment and management of children with various neurodevelopmental disorders since its establishment in 1991.
Naila Zaman Khan, Mustafa Mahbub, Mahmuda Khatun, Humaira Muslima, Dilara Begum, Rezina Parvin, Monowara Parveen, Farzana Islam   +7 more
openaire   +2 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Diagnostic Subtypes of Feeding Disorders in Infancy: An Empirical Contribution on Mother-Child Feeding Interactions, Child and Mother Psychopathological Risk Factors

, 2013
DIAGNOSTIC SUBTYPES OF FEEDING DISORDERS IN INFANCY: AN EMPIRICAL CONTRIBUTION ON MOTHER-CHILD FEEDING INTERACTIONS, CHILD AND MOTHER PSYCHOPATHOLOGICAL RISK FACTORS Introduction: DC:0-3, the manual of Mental Health and Developmental Disorders of ...
LUCARELLI, LOREDANA
core  

Predicting autism spectrum disorder severity in children based on specific language milestones: a random forest model approach

Child and Adolescent Psychiatry and Mental Health
Background Language impairments are among the most prevalent co-occurring conditions in children with autism spectrum disorder (ASD), and delayed language milestones often serve as early developmental warning signs.
Haiyi Xiong, Xueli Xiang, Xiao Liu, Ting Yang, Jinjin Chen, Jie Chen, Tingyu Li   +6 more
doaj   +1 more source

EEG development in Attention Deficit Hyperactivity Disorder: From child to adult

Clinical Neurophysiology, 2016
Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders found in children. While an extensive literature has documented the EEG in this clinical population, few studies have investigated EEG throughout the lifespan in ADHD.
Clarke, Adam R, Barry, Robert J, Johnstone, Stuart J, McCarthy, Rory, Selikowitz, Mark   +4 more
openaire   +3 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Are developmental disorders like cases of adult brain damage? Implications from connectionist modelling [PDF]

, 2002
It is often assumed that similar domain-specific behavioural impairments found in cases of adult brain damage and developmental disorders correspond to similar underlying causes, and can serve as convergent evidence for the modular structure of the ...
Thomas, Michael S.C., Thomas, MSC, Karmiloff-Smith, Annette, Karmiloff-Smith, A   +3 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source