Results 101 to 110 of about 17,977,226 (311)

ELK1 inhibition alleviates amyloid pathology and memory decline by promoting the SYVN1-mediated ubiquitination and degradation of PS1 in Alzheimer’s disease

Experimental and Molecular Medicine
ELK1 is a member of the E-twenty-six transcription factor family and is usually activated by phosphorylation at Ser383 and Ser389 by extracellular signal-regulated kinase 1/2 (ERK1/2).
Lilin Yi, Junjie Li, Yan He, Jiaojiao Wang, Maoju Wang, Song Guo, Man Luo, Bin Wu, Mingliang Xu, Qiuyun Tian, Yepeng Fan, Mulan Chen, Boqing Xu, Lei Xia, Weihong Song, Guiqiong He, Yehong Du, Zhifang Dong   +17 more
doaj   +1 more source

Exosomes from Human Umbilical Cord Mesenchymal Stem Cells Reduce Damage from Oxidative Stress and the Epithelial-Mesenchymal Transition in Renal Epithelial Cells Exposed to Oxalate and Calcium Oxalate Monohydrate

Stem Cells International, 2019
Objective. To investigate whether exosomes from human umbilical cord mesenchymal stem cells (hUC-MSCs) can protect against the toxic effects of oxalate and calcium oxalate monohydrate (COM) crystals in human proximal tubular epithelial (HK-2) cells ...
Dian Li, Dan Zhang, Bo Tang, Yue Zhou, Wenhao Guo, Qing Kang, Zhang Wang, Lianju Shen, Guanghui Wei, Dawei He   +9 more
doaj   +1 more source

The particularities of the psychoemotional development of the child with autism spectrum disorders

Psihologie. Revista științifico-practică = Psychology. Scientific-practical journal
The article provides an overview of theoretical approaches regarding the symptoma­tology of children with autism spectrum disorders. A review of the specialized literature confirms that the autistic child develops disharmoniously, with certain dimensions of their personality underdeveloped, while others often exceed typical developmental levels.
openaire   +2 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Maternal mood and anxiety disorders and child school readiness: a Manitoba population-based study [PDF]

, 2015
Title: Maternal Mood and Anxiety Disorders and Child School Readiness: A Manitoba Population-Based Study Objective: This study examined the relationship between several features of maternal Mood/Anxiety – timing, recurrence/persistence and severity ...
Comaskey, Brenda
core  

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Birth outcomes in women with eating disorders in the Norwegian Mother and Child cohort study (MoBa) [PDF]

, 2009
We explored the impact of eating disorders on birth outcomes in the Norwegian Mother and Child Cohort Study (MoBa)
Torgersen, Leila, Lie, Kari Kveim, Hamer, Robert M., Reichborn-Kjennerud, T, Siega-Riz, AM, Berg, Cecilie Knoph, Sullivan, P, Von, Holle A, Siega-Riz, Anna Maria, Bulik, CM, Reichborn-Kjennerud, Ted, Torgersen, L, Lie, KK, Sullivan, Patrick, Hamer, RM, Bulik, Cynthia M., Von Holle, Ann, Berg, CK   +17 more
core   +1 more source

Postnatal Growth Patterns and Deviations in Singleton and Twin Infants: A Prospective Cohort Study on Infants Appropriate and Small for Gestational Age

Pediatric Discovery
Small for gestational age (SGA) and twin infants are at increased risk of growth deviations, but postnatal catch‐up growth (CUG) patterns across singleton, twin, appropriate for gestational age (AGA), and SGA groups remain unclear.
Yannan Wan, Ting Pan, Zhanzhan Zhang, Yuanfeng Zhong, Qian Chen, Xuelin Xia, Lin Zhu, Li Chen, Xuan Zhang   +8 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Peaks Island Child Development Center [broadside] [PDF]

, 1978
[ca. 1978] Peaks Island Child Development Center is a program of comprehensive day care services to children and families of Peaks Island. Sponsored by:Diocesan Human Relations ServicesUnited Way, Inc.City of Portland, Community Development ...
Peaks Island Child Development Center
core