Results 101 to 110 of about 1,768,149 (356)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Alterations of Brain Structural and Functional Connectivity Networks and Its Correlations With Cognitive Function in Patients With Hypothalamic Syndrome Following Craniopharyngioma Resection

Brain and Behavior
Objective This study aims to investigate the alterations in structural and functional connectivity networks (SCN and FCN) in children with hypothalamic syndrome (HS) following craniopharyngioma resection and to explore the relationship between these ...
Shuang Li, Junya Ma, Zanyong Tong, Hongting Jiang, Lusheng Li, Yuting Zhang   +5 more
doaj   +1 more source

Child and Adolescent Mental Health Around The World: Challenges for Progress [PDF]

, 2005
Child and adolescent mental health is an essential component of overall health and its importance is gaining increased recognition. Current events have heightened an interest in the mental health of youth. Unfortunately, too often this is due to concerns
Belfer, Myron L
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

THE INFLUENCE OF SLEEP DISORDERS ON CHILD DEVELOPMENT

Cogitare Enfermagem, 2014
This study aimed to verify, in scientific publications, the influence of sleep disorders on child development. It is an integrative literature review, undertaken in December 2012 and March 2014 in the LILACS, Pubmed, CINAHL, Scopus and Cochrane databases, in the period of publication covering 2003 – March 2014, with the descriptors ‘child development ...
Maria Vera Lúcia Moreira Leitão Cardoso, na Luíza Paula de Aguiar Lélis, Natália Rodrigues Oliveira, Tamires Rebeca Forte Viana, Priscila Araújo Santiago Praciano, Erison Tavares de Oliveira   +5 more
openaire   +1 more source

Prenatal exposure to methadone or buprenorphine: Early childhood developmental outcomes. [PDF]

, 2018
BACKGROUND: Methadone and buprenorphine are recommended to treat opioid use disorders during pregnancy. However, the literature on the relationship between longer-term effects of prenatal exposure to these medications and childhood development is both ...
Coyle, Mara G., Fischer, Gabriele, Heil, Sarah H., Jones, Hendrée E., Kaltenbach, Karol, Martin, Peter R., O\u27Grady, Kevin E, Salisbury, Amy L., Stine, Susan   +8 more
core   +1 more source

Psychopathology in Williams syndrome: the effect of individual differences across the lifespan [PDF]

, 2009
The present research aimed to comprehensively explore psychopathology in Williams syndrome (WS) across the lifespan and evaluate the relationship between psychopathology and age category (child or adult), gender and cognitive ability.
American Psychiatric Association, American Psychiatric Association, Helen F. Dodd, Jefferys D., Karmiloff-Smith A., Kaufman J., Melanie A. Porter, Mervis C. B., Pober B. R., Silverman W. K., Soni S., Switaj D. M., Woodcock R. W.   +12 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Semiology and neurophysiology of clonic seizures in children: a retrospective study

Frontiers in Neurology
ObjectivesTo identify and quantify clonic seizures in children, we retrospectively reviewed the clinical symptoms and neurophysiology of them.MethodsData were obtained from 24 patients presenting with 34 clonic seizures, and their video ...
Qiao Hu, Yuanyuan Luo, Tingsong Li, Siqi Hong, Ping Yuan, Li Jiang   +5 more
doaj   +1 more source