Results 41 to 50 of about 414,015 (269)

Phenotypic characteristics and rehabilitation effect of children with regressive autism spectrum disorder: a prospective cohort study

BMC Psychiatry
Background In this prospective cohort study, we determined the phenotypic characteristics of children with regressive autism spectrum disorder (ASD) and explored the effects of rehabilitation.
Chaoqun Hu, Ting Yang, Jie Chen, Ying Dai, Hua Wei, Qionghui Wu, Hongyu Chen, Dan Long, Yuru Feng, Qiuhong Wei, Qian Zhang, Li Chen, Tingyu Li   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Total colonic aganglionosis in children: clinical manifestations, diagnosis, treatment and outcome

Di-san junyi daxue xuebao, 2020
Objective To explore the clinical features, diagnosis and treatments of total colonic aganglionosis(TCA) in children. Methods We retrospectively analyzed the clinical data of 41 children with TCA (including 31 boys and 10 girls), who were diagnosed and ...
ZHANG Zhenyu, SUN Jing, HOU Jinping, LIU Qingshuang, LIU Wei, LI Xiaoqing, WANG Yi   +6 more
doaj   +1 more source

Inverse association between Helicobacter pylori infection and childhood asthma in a physical examination population: a cross-sectional study in Chongqing, China

BMC Pediatrics, 2022
Background Childhood asthma has substantial effects on children's health. It is important to identify factors in early life that influence childhood asthma.
Donghai Wang, Yuxia Chen, Yuan Ding, Jinwei Tu   +3 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Global prevalence of occult hepatitis B virus infection in HBcAb-positive individuals: a systematic review and meta-analysis

Scientific Reports
Many people worldwide test negative for hepatitis B surface antigen (HBsAg) but positive for hepatitis B core antibody (HBcAb), posing potential clinical challenges of occult hepatitis B virus (HBV) infection (OBI), including viral reactivation and ...
Yuting Yang, Huiwu Xing, Guojin Wu, Yao Zhao   +3 more
doaj   +1 more source

Parental smoking and risk of hypospadias: An updated meta-analysis of observational studies

Frontiers in Pediatrics, 2023
BackgroundInconsistent relationships have been shown between cigarette smoking and hypospadias in offspring. The purpose of this study was to summarize epidemiological evidence to evaluate the relationship between parental smoking and the risk of ...
Zi-Han Ye, Zi-Han Ye, Zi-Han Ye, Hong-Song Chen, Hong-Song Chen, Hong-Song Chen, Zhi-Cheng Zhang, Zhi-Cheng Zhang, Zhi-Cheng Zhang, Xiao Wang, Xiao Wang, Xiao Wang, Xing Liu, Xing Liu, Xing Liu, Guang-Hui Wei, Guang-Hui Wei, Guang-Hui Wei   +17 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Naringenin inhibits phosphorylated protein kinase C-δ and reduces inflammatory injury in rats after intracerebral hemorrhage

Di-san junyi daxue xuebao, 2020
Objective To investigate the effects of naringenin (NGN) on inflammatory injury after intracerebral hemorrhage (ICH) in rats and its possible molecular mechanism.
XIAO Han, ZHANG Li, WANG Lu, CHEN Hui, GAN Hui, GAN Hui, ZHENG Shuyue   +6 more
doaj   +1 more source