Results 61 to 70 of about 414,015 (269)

Alterations of Brain Structural and Functional Connectivity Networks and Its Correlations With Cognitive Function in Patients With Hypothalamic Syndrome Following Craniopharyngioma Resection

Brain and Behavior
Objective This study aims to investigate the alterations in structural and functional connectivity networks (SCN and FCN) in children with hypothalamic syndrome (HS) following craniopharyngioma resection and to explore the relationship between these ...
Shuang Li, Junya Ma, Zanyong Tong, Hongting Jiang, Lusheng Li, Yuting Zhang   +5 more
doaj   +1 more source

The conundrums of human development – implications for the study of child and adolescent disorder [PDF]

Journal of Child Psychology and Psychiatry, 2017
The conundrums inherent in the study of child and adolescent development are likely never far from the minds of the readers of JCPP . The complexity of development is flagged clearly in this issue.
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Child Psychiatric Disorders Presenting to a Tertiary Multidisciplinary Child Development Service in Bangladesh

Bangladesh Journal of Child Health, 2012
Background: Shishu Bikash Kendra (SBK or Child Development Center) of the Dhaka Shishu (Children’s) Hospital (DSH) has been using a multidisciplinary approach for assessment and management of children with various neurodevelopmental disorders since its establishment in 1991.
Naila Zaman Khan, Mustafa Mahbub, Mahmuda Khatun, Humaira Muslima, Dilara Begum, Rezina Parvin, Monowara Parveen, Farzana Islam   +7 more
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Predicting autism spectrum disorder severity in children based on specific language milestones: a random forest model approach

Child and Adolescent Psychiatry and Mental Health
Background Language impairments are among the most prevalent co-occurring conditions in children with autism spectrum disorder (ASD), and delayed language milestones often serve as early developmental warning signs.
Haiyi Xiong, Xueli Xiang, Xiao Liu, Ting Yang, Jinjin Chen, Jie Chen, Tingyu Li   +6 more
doaj   +1 more source

Semiology and neurophysiology of clonic seizures in children: a retrospective study

Frontiers in Neurology
ObjectivesTo identify and quantify clonic seizures in children, we retrospectively reviewed the clinical symptoms and neurophysiology of them.MethodsData were obtained from 24 patients presenting with 34 clonic seizures, and their video ...
Qiao Hu, Yuanyuan Luo, Tingsong Li, Siqi Hong, Ping Yuan, Li Jiang   +5 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

EEG development in Attention Deficit Hyperactivity Disorder: From child to adult

Clinical Neurophysiology, 2016
Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders found in children. While an extensive literature has documented the EEG in this clinical population, few studies have investigated EEG throughout the lifespan in ADHD.
Clarke, Adam R, Barry, Robert J, Johnstone, Stuart J, McCarthy, Rory, Selikowitz, Mark   +4 more
openaire   +3 more sources