Results 101 to 110 of about 1,477,434 (241)

Reflections of a Mi’kmaq social worker on a quarter of a century work in First Nations child welfare

, 2007
First Nations people would argue that the ‘Sixties Scoop’ of removing their children from their homes and culture never ended. First Nations children entering ‘care’ of child welfare agencies has increased significantly since the 1960s and 1970s. Storying
MacDonald, Nancy, MacDonald, Judy
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Social media food marketing landscape of children living in Republic of Srpska, Bosnia and Herzegovina: Piloting the WHO CLICK framework, results and lessons learned

Journal of Health, Population and Nutrition
Background Monitoring food marketing that reaches children is key to effective implementation of any regulation. The Best-ReMaP European Union Joint Action aimed to test the feasibility of using monitoring protocols (developed by the World Health ...
Jelena Niškanović, Dragana Stojisavljević, Magdalena Muc, Mimi Tatlow-Golden, Dijana Manigoda   +4 more
doaj   +1 more source

The American child.

, 1919
Vol. 40, no. 2 was not published.Supplements accompany some issues.Mode of access: Internet.Issued by: National Child Labor Committee, May 1919-; National Committee on Employment of Youth, 1959-Vol. 40-44.
National Committee on Employment of Youth (U.S.), National Child Labor Committee (U.S.)   +1 more
core  

Influencer marketing and z generation

, 2020
Szakdolgozatom célja, hogy részletesen bemutassam az influencer marketinget, mint az online marketing egyik legnépszerűbb és leghatékonyabb formáját a Z generáció tekintetébenKereskedelem és marketingBSc ...
Tánczos, Anett
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The effect of influencer marketing on the Z generation

Dolgozatomban az influencer marketing hatásait vizsgáltam. Vizsgálati alanyaim leginkább a Z generációra vonatkoznak. Magát az influencer jelenséget, történetét mutattam be. Különböző hatásait vizsgáltam az egyénekre nézve.
Kerekes, Dorka
core