Results 81 to 90 of about 1,477,434 (241)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Wanted: Moral Courage in Canadian Child Welfare
, 2011 Child welfare stifles change and innovation in a system that desperately needs it by promoting conformity and awarding subordination to bad ideas (Blackstock, 2009).
Blackstock, Cindy
core +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Novel nicotine and tobacco products in pediatric age: a joint position paper
Italian Journal of PediatricsElectronic nicotine delivery systems (ENDS), heated tobacco products (HTP), and nicotine pouches have rapidly gained popularity among adolescents, driven by appealing flavors, targeted marketing strategies, and widespread misperceptions of reduced harm ...
Antonio Corsello +8 more
doaj +1 more source
Rekindling the Sacred Fire for Children and Families
, 2019 This video describes the partnership between the Sun Lodge Village and Peguis Child and Family Services in Peguis First Nation, Manitoba. Together we are providing opportunities for families, youth, and children to find their way back to traditional ...
Peguis Child and Family Services +3 more
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The influence of bibliotherapy on child perfectionism
Revista de Psicología, 2020 Perfectionism is a personality disposition characterized by the setting of excessively high performance standards. Several studies have proved the relationship between perfectionism and psychological maladjustment in children and adolescents. The aim of this study was to determine the effectiveness of bibliotherapy based on children's literature -more ...
Leonardo Andres Aguilar Durán +1 more
openaire +1 more source
Here be dragons! Reconciling Indigenous and Western knowledge to improve Aboriginal child welfare
, 2007 The authors discuss the factors regarding the reconciliation movement in reconciling Indigenous and Western Knowledge to improve child welfare practice with respect to Aboriginal peoples.
Bastien, Betty, LaFrance, Jean
core +1 more source