Results 61 to 70 of about 248,682 (284)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Neurodevelopmental domain characteristics and their association with core symptoms in preschoolers with autism spectrum disorder in China: a nationwide multicenter study

BMC Psychiatry, 2022
Background Autism spectrum disorder (ASD) is a group of clinically heterogenic neurodevelopmental disorders, with intellectual disability being one of its common comorbidities.
Qian Zhang, Qiu Li, Ting Yang, Li Chen, Ying Dai, Hua Wei, Ke Wang, Feiyong Jia, Lijie Wu, Yan Hao, Ling Li, Jie Zhang, Xiaoyan Ke, Mingji Yi, Qi Hong, Jinjin Chen, Shuanfeng Fang, Yichao Wang, Qi Wang, Chunhua Jin, Jie Chen, Tingyu Li   +21 more
doaj   +1 more source

Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children [PDF]

, 2015
Enteric infections, enteropathy and undernutrition in early childhood are preventable risk factors for child deaths, impaired neurodevelopment, and later life metabolic diseases.
Guerrant, RL, Havt, A, Leite, Á, Lima, AAM, Lima, NL, Mayneris-Perxachs, J, Moore, SR, Moura, AF, Pinkerton, R, Soares, AM, Swann, JR   +10 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Serum Folate Status Is Primarily Associated With Neurodevelopment in Children With Autism Spectrum Disorders Aged Three and Under—A Multi-Center Study in China

Frontiers in Nutrition, 2021
Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Folate has been demonstrated to be associated with ASD. However, current studies on the correlation between folate and symptoms of children with ASD have inconsistent ...
Qiu Li, Ting Yang, Li Chen, Ying Dai, Li-Jie Wu, Fei-Yong Jia, Yan Hao, Ling Li, Jie Zhang, Xiao-Yan Ke, Ming-Ji Yi, Qi Hong, Jin-Jin Chen, Shuan-Feng Fang, Yi-Chao Wang, Qi Wang, Chun-Hua Jin, Zhi-Fang Dong, Jie Chen, Ting-Yu Li   +19 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Clinical characteristics of 27 children with febrile infection‐related epilepsy syndrome in a single center

Pediatric Discovery
To investigate the clinical characteristics of febrile infection‐related epilepsy syndrome (FIRES). We used trajectory analysis and logistic regression analysis to investigate the clinical characteristics and prognostic risk factors respectively.
Juan Wang, Yongfang Liu, Lingling Xie, Min Cheng, Lianying Feng, Yuhang Liu, Yi Guo, Li Jiang   +7 more
doaj   +1 more source

Nutrition Country Profile United Republic of Tanzania [PDF]

, 2008
Population, Economic, Tanzania, urbanization ...
Bader, Estelle, Kinabo, Joyce, Palma, Giulia   +2 more
core  

A qualitative study of factors affecting mental health amongst low-income working mothers in Bangalore, India. [PDF]

, 2014
BackgroundLow-income urban working mothers face many challenges in their domestic, environmental, and working conditions that may affect their mental health.
Heymann, Sally Jody, Rajaraman, Divya, Travasso, Sandra Mary   +2 more
core   +3 more sources