Results 71 to 80 of about 248,682 (284)

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

Contemporary factors affecting serum 25-hydroxyvitamin D concentrations in Chinese children aged 2–6 years

Public Health Nutrition
Objective: We investigated vitamin D (VitD) nutritional status in children aged 2–6 years to provide a basis for prevention and intervention strategies for VitD deficiency (VitDD) in Chinese children.
Qian Chen, Ting Yang, Yongfang Liu, Jie Chen, Qian Cheng, Tingyu Li   +5 more
doaj   +1 more source

Sleep problems in children with autism spectrum disorder: a multicenter survey

BMC Psychiatry, 2021
Background High prevalence of sleep problems have been reported in children with Autism Spectrum Disorder (ASD). This study aims to investigate the sleep conditions of ASD children in China, and explore the relationship between the common sleep problems ...
Hongyu Chen, Ting Yang, Jie Chen, Li Chen, Ying Dai, Jie Zhang, Ling Li, Feiyong Jia, Lijie Wu, Yan Hao, Xiaoyan Ke, Mingji Yi, Qi Hong, Jinjin Chen, Shuanfeng Fang, Yichao Wang, Qi Wang, Chunhua Jin, Tingyu Li   +18 more
doaj   +1 more source

Early life exposure to triclosan from antimicrobial daily necessities may increase the potential risk of autism spectrum disorder: A multicenter study in China

Ecotoxicology and Environmental Safety, 2022
Background: Autism spectrum disorders (ASD) are a group of complex neurodevelopmental disorders with unclear etiologies. Our recent work indicated that maternal exposure to triclosan (TCS) significantly increased the autistic-like behavior in rats ...
Qionghui Wu, Ting Yang, Li Chen, Ying Dai, Hua Wei, Feiyong Jia, Yan Hao, Ling Li, Jie Zhang, Lijie Wu, Xiaoyan Ke, Mingji Yi, Qi Hong, Jinjin Chen, Shuanfeng Fang, Yichao Wang, Qi Wang, Chunhua Jin, Ronggui Hu, Jie Chen, Tingyu Li   +20 more
doaj   +1 more source

Autism Spectrum Disorder and the Child\u27s Weight–Related Behaviors: A Parents\u27 Perspective [PDF]

, 2016
Purpose To explore parent perspectives of how the attributes of their child\u27s autism spectrum disorder(ASD) impact nutrition, physical activity, screen time behaviors and risk for obesity.
Apollon, Fallon, Bonis, Susan A., Johnson, Norah L., Polfuss, Michele, Sawin, Kathleen   +4 more
core   +1 more source

DNA methylation and socioeconomic status in a Mexican-American birth cohort. [PDF]

, 2018
Background: Maternal social environmental stressors during pregnancy are associated with adverse birth and child developmental outcomes, and epigenetics has been proposed as a possible mechanism for such relationships.
Coker, Eric, Eskenazi, Brenda, Gunier, Robert, HOLLAND, Nina, Huen, Karen   +4 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Effects of sandplay therapy in reducing emotional and behavioural problems in school‐age children with chronic diseases: A randomized controlled trial

Nursing Open, 2021
Purpose Children with chronic diseases exhibit a higher incidence of emotional–behavioural problems. Though sandplay therapy is a universally recognized psychological treatment method, experimental evidence for this form of therapy is lacking.
Judan Tan, Huaying Yin, Tuo Meng, Xiaoli Guo   +3 more
doaj   +1 more source

The comparison of under-five-children’s nutrition status among ethnic groups in North of Iran, 1998 - 2013; Results of a three stages cross-sectional study [PDF]

, 2015
Background: Despite improvements in child health, malnutrition still remains one of the main public health challenges in Iran. Objectives: The aim of this study was to compare under nutrition among under-five children with regard to ethnicity in rural ...
Veghari, G.
core   +1 more source