Results 91 to 100 of about 1,598,227 (311)

Of Chickens and Eggs−−The Compatibility of Moral Rights and Consequentialist Analyses [PDF]

open access: yes, 1989
Philosophers are accustomed to thinking of moral rights and consequentialist analyses as fundamentally incompatible. They frequently debate cases--both hypothetical and real--in which rights and consequences are in conflict.
Barnett, Randy E
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Child Rights in Primary Schools – The Situation and Expectations

open access: yesCenter for Educational Policy Studies Journal, 2019
School is the most suitable place for students to learn about child rights and where these rights are to be respected. In the research we have conducted, the objective was to examine the knowledge of primary school students about the rights of the child ...
Jelena Stamatović   +1 more
doaj  

Do international treaties promote development ? the convention on the rights of the child and basic immunization [PDF]

open access: yes
Little evidence is available on whether changing global rules so as to promote human rights can enhance development outcomes. The Convention on the Rights of the Child was almost universally ratified by the mid-1990s, but it is unclear whether treaty ...
Gauri, Varun
core  

Beyond the new horizon : trends and issues in residential child care [PDF]

open access: yes, 2004
High profile scandals of abuse and poor outcomes of children in residential child care have contributed to a government focus on improving the quality of services.
Kendrick, Andrew
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Freedom at Work: Campaign Toolkit 2010 [PDF]

open access: yes, 2009
This guide examines the ways in which the right to associate freely is violated in workplaces around the world. The first section outlines why defending the right to organize can help empower working women, end trafficking, curb forced and child labor ...
International Labor Rights Forum
core   +2 more sources

Convention on the Rights of the Child [PDF]

open access: yes, 1989
UNICEF’s Convention on the Rights of the Child, approved on November 20 ...
UNICEF
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Climate Action and the UNCRC: A ‘Postpaternalist’ World Where Children Claim Their Own Rights

open access: yesYouth
In this paper, it is argued that we are in a ‘postpaternalist’ era for children’s rights, involving grassroots action from children (for the first time, on a global scale) rather than well-meaning adults ‘giving’ children their rights.
Aoife Daly   +7 more
doaj   +1 more source

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