Results 71 to 80 of about 1,334,692 (318)

It's not rocket science: The perspectives of Indigenous early childhood workers on supporting the engagement of Indigenous families in early childhood settings

, 2012
This paper presents the findings from semi-structured interviews with six Indigenous Australian early childhood workers who were asked about how Indigenous families might be better supported to engage with early childhood education and care services. The
Trudgett, M, Grace, R, Grace, Rebekah (R19197), Trudgett, Michelle (R19725)   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Sustaining Early Success: Delaware’s Strategic Plan for a Comprehensive Early Childhood System

, 2013
2013 Annual Report and Strategic Plan of the Delaware Early Childhood ...
Delaware Early Childhood Council
core  

Evaluation of the Speech and Language Therapy Service of Tallaght West Childhood Development Initiative [PDF]

, 2012
A retrospective evaluation of the Childhood Development Initiative (CDI) Speech and Language Therapy Service was undertaken. The design consisted of two strands.
Keegan, Siobhán, Eimear Goulding, Goulding, Eimer, Siobhan Keegan, Hayes, Noirin, Nóirín Hayes   +5 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Association between early childhood caries and parental education and the link to the sustainable development goal 4: a scoping review

BMC Oral Health
Background The goal of the United Nations Sustainable Development Goal (SDG) 4 is to ensure inclusive and equitable quality education and promote lifelong learning opportunities for all.
Morenike Oluwatoyin Folayan, Elisa Maria Rosa de Barros Coelho, Imen Ayouni, Arthemon Nguweneza, Ola Barakat Al-Batayneh, Hamideh Daryanavard, Duangporn Duangthip, Ivy Guofang Sun, Arheiam Arheiam, Jorma I. Virtanen, Balgis Gaffar, Maha El Tantawi, Robert J Schroth, Carlos Alberto Feldens   +13 more
doaj   +1 more source

Fish oil and vitamin D in pregnancy for the prevention of early childhood asthma: study protocol for two double-blinded, randomised controlled trials

BMJ Open
Introduction Previous randomised controlled trials (RCTs) have indicated a protective role of pregnancy supplementation with fish oil and high-dose vitamin D, respectively, on offspring asthma, infections and several other disorders in early childhood ...
Klaus Bønnelykke, Jakob Stokholm, Rebecca Vinding, Bo Chawes, Julie Nyholm Kyvsgaard, Ulrik Ralfkiaer, Marianne Mikkelsen, Nicklas Brustad, Sarah Brandt, Nilo Vahman   +9 more
doaj   +1 more source

Re-thinking pedagogies: New immigrants in Aotearoa New Zealand early childhood settings

, 2014
This chapter examines the importance of teacher orientations towards immigrant children, families, and teachers in early childhood education settings in Aotearoa New Zealand.
Arndt, Sonja Kathrina, Arndt, Sonja
core  

A snapshot of substitute early childhood teachers in Sweden and Australia: Differences in training, regulation and quality

, 2018
Substitute teachers play an important role within early childhood education. They are expected to take on the roles and responsibilities of working with children and parents when the regular teacher is away.
Bigsten, Airi,, Airi Bigsten, Karlsson, Rauni,, Garvis, Susanne, Rauni Karlsson, Bigsten, Airi, Garvis, Susanne,, Susanne Garvis, Karlsson, Rauni   +8 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source