Results 121 to 130 of about 33,104 (203)

Pretreatment seizure semiology in childhood absence epilepsy. [PDF]

Neurology, 2017
Kessler SK, Shinnar S, Cnaan A, Dlugos D, Conry J, Hirtz DG, Hu F, Liu C, Mizrahi EM, Moshé SL, Clark P, Glauser TA, Childhood Absence Epilepsy Study Group.   +12 more
europepmc   +1 more source

Functional profiling of STXBP1 missense variants using a novel dual‐readout fluorometric assay

Epilepsia, EarlyView.
Abstract Objective STXBP1‐related disorders (STXBP1‐RD) are among the most common genetic neurodevelopmental disorders, marked by early onset epilepsy, global developmental delay, and motor impairments. Many missense variants remain uncharacterized, limiting accurate variant interpretation and hindering development of precision therapies.
Elisa A. Waxman, Jennine M. Dawicki‐McKenna, Ian McSalley, Anna J. Prentice, Torrey A. Chisari, Sarah M. Ruggiero, Jillian L. McKee, Alex J. Felix, Giulia Pavani, Benjamin L. Prosser, Michael J. Boland, Ingo Helbig   +11 more
wiley   +1 more source

Behavior Problems in Childhood Absence Epilepsy: A Chicken or Egg Problem. [PDF]

Epilepsy Curr, 2018
Salpekar J.
europepmc   +1 more source

Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy. [PDF]

Ann Neurol, 2017
Glauser TA, Holland K, O'Brien VP, Keddache M, Martin LJ, Clark PO, Cnaan A, Dlugos D, Hirtz DG, Shinnar S, Grabowski G, Childhood Absence Epilepsy Study Group.   +11 more
europepmc   +1 more source

Theta oscillations, epileptogenesis, and focal seizures in rodent models of mesial temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Theta oscillations (4–12 Hz) are a prominent network rhythm within hippocampal and parahippocampal structures. Driven by cholinergic and γ‐aminobutyric acidergic inputs originating from the medial septum, physiological theta gates network excitability to control spatial navigation, memory encoding, and sensorimotor integration during specific ...
Maxime Lévesque, Massimo Avoli
wiley   +1 more source

Pretreatment behavior and subsequent medication effects in childhood absence epilepsy. [PDF]

Neurology, 2017
Shinnar RC, Shinnar S, Cnaan A, Clark P, Dlugos D, Hirtz DG, Hu F, Liu C, Masur D, Weiss EF, Glauser TA, Childhood Absence Epilepsy Study Group.   +11 more
europepmc   +1 more source

Kv3.1 activation suppresses provoked and spontaneous seizures in a mouse Dravet syndrome model

Epilepsia, EarlyView.
Abstract Objective γ‐Aminobutyric acidergic (GABAergic) parvalbumin‐positive (PV+) interneurons are critical for maintaining cortical inhibitory tone, with their dysfunction predictably leading to epilepsy. Rapid PV+ interneuron firing is essential for their normal function and is maintained in part by potassium voltage‐gated channels.
Sheryl Anne D. Vermudez, Mustafa Q. Hameed, Yongho Choe, Gabrielle E. McGinty, Amanda M. Liebhardt, Rui Lin, Benjamin Hui, Yini Liang, David J. Arce, Henry H. C. Lee, Mustafa Sahin, Alexander Rotenberg   +11 more
wiley   +1 more source

Attention Contributes to Arithmetic Deficits in New-Onset Childhood Absence Epilepsy. [PDF]

Front Psychiatry, 2017
Cheng D, Yan X, Gao Z, Xu K, Chen Q.
europepmc   +1 more source

Limited sex‐specific structural alterations across common epilepsies: A worldwide ENIGMA study

Epilepsia, EarlyView.
Abstract Objective Epilepsy is characterized by widespread cortical and subcortical structural alterations beyond the epileptic zone. Importantly, the clinical manifestation of epilepsy, including seizure types, psychiatric comorbidities, and treatment responses, has been shown to differ between sexes. However, sex differences in structural alterations
Huantao Wen, Bin Wan, Taha Gholipour, Ke Xie, Judy Chen, Bianca Serio, Meike D. Hettwer, Marina K. M. Alvim, Donatello Arienzo, Rafael Batista João, Tobias Bauer, Andrea Bernasconi, Neda Bernasconi, Paolo Bonanni, Maria Eugenia Caligiuri, Fernando Cendes, Raphaël Christin, Luis Concha, Arielle Dascal, Edward Davoodi Boyd, Orrin Devinsky, Niels K. N. Focke, Francesco Fortunato, Marian Galovic, Antonio Gambardella, Renzo Guerrini, Sean N. Hatton, Mirana Iliza, Sara Inati, Victoria Ives‐Deliperi, Robert‐Paul Juster, Jonathan K. Kleen, Mohamad Z. Koubeissi, Angelo Labate, Sara Larivière, Meng Law, Matteo Lenge, Stefano Meletti, Patrick B. Moloney, Marlo Naish, Alexander Ngo, Terence J. O'Brien, Raluca Pana, Sofia Panzeri, Heath Pardoe, Erik H. U. Rauf, Antonella Riva, Raúl Rodríguez‐Cruces, Jessica Royer, Theodor Rüber, Ella Sahlas, Lucas Scárdua‐Silva, Kai Michael Schubert, Leigh N. Sepeta, Mariasavina Severino, Benjamin Sinclair, Hamid Soltanian‐Zadeh, Travis Stoub, Pasquale Striano, Sophia I. Thomopoulos, Nina V. Valientes, Anna Elisabetta Vaudano, Lucy Vivash, Clarissa L. Yasuda, Paul M. Thompson, Sanjay M. Sisodiya, Carrie R. McDonald, Boris C. Bernhardt, Sofie L. Valk   +68 more
wiley   +1 more source

Evolving Tale of Childhood Absence Epilepsy: Finally Better News? [PDF]

Epilepsy Curr, 2016
Gupta A.
europepmc   +1 more source