Results 101 to 110 of about 6,129,228 (249)

Pediatric Cushing disease: disparities in disease severity and outcomes in the Hispanic and African-American populations. [PDF]

, 2017
BackgroundLittle is known about the contribution of racial and socioeconomic disparities to severity and outcomes in children with Cushing disease (CD).MethodsA total of 129 children with CD, 45 Hispanic/Latino or African-American (HI/AA) and 84 non ...
Alexander S Karageorgiadis, Alexandra Gkourogianni, AM Linabery, B Moy, BB Strickland, C Zeng, CA Stratakis, Charalampos Lyssikatos, CL Ogden, Constantine A Stratakis, D Mukherjee, D Mukherjee, D Mukherjee, E Ward, Elena Belyavskaya, ET Petridou, G Aicardi, J Etxabe, JK Lambert, LX Clegg, M Lodish, Margaret F Keil, Maya B Lodish, MB Lodish, Mihail Zilbermint, MJ Bolland, MT Halpern, Ninet Sinaii, NS Kadan-Lottick, OMB (Office of Management and Budget), P Aristizabal, Prashant Chittiboina, R Siegel, RN Clayton, RR Lonser, S Bhatia, S Srinivasan, Sharon H Jackson   +37 more
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Differentiation of Human Embryonic Stem Cells to Sympathetic Neurons: A Potential Model for Understanding Neuroblastoma Pathogenesis

Stem Cells International, 2018
Background and Aims. Previous studies modelling human neural crest differentiation from stem cells have resulted in a low yield of sympathetic neurons.
Jane Carr-Wilkinson, Nilendran Prathalingam, Deepali Pal, Mohammad Moad, Natalie Lee, Aishwarya Sundaresh, Helen Forgham, Peter James, Mary Herbert, Majlinda Lako, Deborah A. Tweddle   +10 more
doaj   +1 more source

Surveillance for Late Effects in Childhood Cancer Survivors.

Journal of Clinical Oncology, 2018
Many childhood cancer survivors carry a significant risk for late morbidity and mortality, a consequence of the numerous therapeutic exposures that contribute to their cure.
W. Landier, R. Skinner, W. H. Wallace, L. Hjorth, R. L. Mulder, F. L. Wong, Y. Yasui, N. Bhakta, L. Constine, S. Bhatia, L. Kremer, M. Hudson   +11 more
semanticscholar   +1 more source

The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia

Blood Cancer Journal
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that expresses high levels of the enzyme aldo-keto reductase family 1 member C3 (AKR1C3).
Cara E. Toscan, Hannah McCalmont, Amir Ashoorzadeh, Xiaojing Lin, Zhe Fu, Louise Doculara, Hansen J. Kosasih, Roxanne Cadiz, Anthony Zhou, Sarah Williams, Kathryn Evans, Faezeh Khalili, Ruilin Cai, Kristy L. Yeats, Andrew J. Gifford, Russell Pickford, Chelsea Mayoh, Jinhan Xie, Michelle J. Henderson, Toby N. Trahair, Adam V. Patterson, Jeff B. Smaill, Charles E. de Bock, Richard B. Lock   +23 more
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Myelolytic Treatments Enhance Oncolytic Herpes Virotherapy in Models of Ewing Sarcoma by Modulating the Immune Microenvironment

Molecular Therapy: Oncolytics, 2018
Ewing sarcoma is a highly aggressive cancer that promotes the infiltration and activation of pro-tumor M2-like macrophages. Oncolytic virotherapy that selectively infects and destroys cancer cells is a promising option for treating Ewing sarcoma.
Nicholas L. Denton, Chun-Yu Chen, Brian Hutzen, Mark A. Currier, Thomas Scott, Brooke Nartker, Jennifer L. Leddon, Pin-Yi Wang, Rachelle Srinivas, Kevin A. Cassady, William F. Goins, Timothy P. Cripe   +11 more
doaj   +1 more source

Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity

Nature Communications, 2020
Here, using methylCIBERSORT, the authors characterize the tumour-immune microenvironment of paediatric central nervous system (CNS) tumours and its association with tumour type and prognosis.
Yura Grabovska, Alan Mackay, Patricia O’Hare, Stephen Crosier, Martina Finetti, Edward C. Schwalbe, Jessica C. Pickles, Amy R. Fairchild, Aimee Avery, Julia Cockle, Rebecca Hill, Janet Lindsey, Debbie Hicks, Mark Kristiansen, Jane Chalker, John Anderson, Darren Hargrave, Thomas S. Jacques, Karin Straathof, Simon Bailey, Chris Jones, Steven C. Clifford, Daniel Williamson   +22 more
doaj   +1 more source

Association of Exercise With Mortality in Adult Survivors of Childhood Cancer

JAMA Oncology, 2018
Importance Adult survivors of childhood cancer are at excess risk for mortality compared with the general population. Whether exercise attenuates this risk is not known.
Jessica M. Scott, Nan Li, Qi Liu, Y. Yasui, W. Leisenring, P. Nathan, T. Gibson, S. Armenian, T. Nilsen, K. Oeffinger, K. Ness, S. C. Adams, L. Robison, G. Armstrong, L. Jones   +14 more
semanticscholar   +1 more source

Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood.

Metabolism: Clinical and Experimental, 2019
Prevalence of childhood obesity has worldwide more than doubled since 1980. Underlying factors are complex and are far from completely understood. Strategies to prevent childhood obesity have mainly focused on behavioral intervention; and obesity therapy
Susann Weihrauch-Blüher, P. Schwarz, J. Klusmann   +2 more
semanticscholar   +1 more source

A systematic review of the link between childhood obesity and adult cancers [PDF]

, 2016
Over the past three decades, Americans’ rates of overweight and obese have steadily increased. It has been suggested that childhood obesity may increase the risk of cancer in adulthood. Much literature has focused on specific cancers or the mechanisms of
Schumacher, Makaila A.
core   +1 more source

A Review of Literature on Health-Related Quality of Life of Retinoblastoma Survivors. [PDF]

, 2020
Background: Retinoblastoma is a malignant tumor of the eye that typically presents in early childhood and occurs in approximately 1 in 20,000 births. While active treatment of the tumor is typically completed in childhood, survivors often suffer from ...
Belson, Paula J, Brecht, Mary-Lynn, Eastwood, Jo-Ann, Hays, Ron D, Pike, Nancy A   +4 more
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